The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology (한방안이비인후피부과학회지)

The Society of Korean Medicine Ophthalmology, Otolaryngology & Dermatology (대한한방안이비인후피부과학회)
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Anti-inflammatory effects of herbal medicines(Rubus coreanus, Rehmanniae Radix, Houttuynia cordata, Betulae cortex) EtOH extract on acute atopic dermatitis mice

급성 아토피 피부염 마우스 모델에서 한약조합약물의 염증반응 진정효과

  • Jung, Jae-Hoon (Department of Ophthalmology, Otolaryngology and Dermatology, College of Korean Medicine, Gachon University) ;
  • Kim, Gyung-Jun (Department of Ophthalmology, Otolaryngology and Dermatology, College of Korean Medicine, Gachon University)
  • 정재훈 (가천대학교 한의과대학 한방안이비인후피부과) ;
  • 김경준 (가천대학교 한의과대학 한방안이비인후피부과)
  • Received : 2015.01.07
  • Accepted : 2015.02.04
  • Published : 2015.02.25
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Abstract

Object : The object of this study was effected of composed of 4 herbal medicines(Rubus coreanus, Rehmanniae Radix, Houttuynia cordata, Betulae cortex) on acute atopic dermatitis mice. Methods : BALB/c mice were divided 4 groups ; normal group, negative control group of acute atopic dermatitis mice induced by DNCB, treated apply to the back skin with the herbal medicine group, and treated orally with herbal medicine group. Treated with herbal medicine and DNCB during 2 weeks. After treated, measured WBCs, RBCs, and platelet in the blood, and analysed mRNA expression of spleen. Result : Composed herbal medicines could reduce WBCs, lymphocytes, monocytes, neutrophils, and eosinophils in the mouse blood. And, could down TNF-${\alpha}$ levels in spleen. In the skin tissue histology results, herbal medicines reduce the cells and T cells. Conclusion : Composed herbal medicines help to another inflammatory disease because they reduce the cells and T cells in the skin tissues. And they have inhibitory effects of TNF-${\alpha}$ mRNA expression, and Th 2 immune responses. Therefore herbal medicines use for an acute atopic dermatitis treatment.

Keywords

References

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