Journal of Periodontal and Implant Science

Korean Academy of Periodontology (대한치주과학회)
권호 표지
DOI QR코드

DOI QR Code

Assessment of dehydrothermally cross-linked collagen membrane for guided bone regeneration around peri-implant dehiscence defects: a randomized single-blinded clinical trial

  • Lee, Jae-Hong (Department of Periodontology, Research Institute for Periodontal Regeneration, Yonsei University College of Dentistry) ;
  • Lee, Jung-Seok (Department of Periodontology, Research Institute for Periodontal Regeneration, Yonsei University College of Dentistry) ;
  • Baek, Won-Sun (Department of Periodontology, Research Institute for Periodontal Regeneration, Yonsei University College of Dentistry) ;
  • Lim, Hyun-Chang (Department of Periodontology, Kyung Hee University School of Dentistry) ;
  • Cha, Jae-Kook (Department of Periodontology, Research Institute for Periodontal Regeneration, Yonsei University College of Dentistry) ;
  • Choi, Seong-Ho (Department of Periodontology, Research Institute for Periodontal Regeneration, Yonsei University College of Dentistry) ;
  • Jung, Ui-Won (Department of Periodontology, Research Institute for Periodontal Regeneration, Yonsei University College of Dentistry)
  • Received : 2015.11.04
  • Accepted : 2015.12.02
  • Published : 2015.12.31
Download PDF
⟨ Previous Next ⟩

Abstract

Purpose: The aim of this study was to determine the clinical feasibility of using dehydrothermally cross-linked collagen membrane (DCM) for bone regeneration around peri-implant dehiscence defects, and compare it with non-cross-linked native collagen membrane (NCM). Methods: Dehiscence defects were investigated in twenty-eight patients. Defect width and height were measured by periodontal probe immediately following implant placement (baseline) and 16 weeks afterward. Membrane manipulation and maintenance were clinically assessed by means of the visual analogue scale score at baseline. Changes in horizontal thickness at 1 mm, 2 mm, and 3 mm below the top of the implant platform and the average bone density were assessed by cone-beam computed tomography at 16 weeks. Degradation of membrane was histologically observed in the soft tissue around the implant prior to re-entry surgery. Results: Five defect sites (two sites in the NCM group and three sites in the DCM group) showed soft-tissue dehiscence defects and membrane exposure during the early healing period, but there were no symptoms or signs of severe complications during the experimental postoperative period. Significant clinical and radiological improvements were found in all parameters with both types of collagen membrane. Partially resorbed membrane leaflets were only observed histologically in the DCM group. Conclusions: These findings suggest that, compared with NCM, DCM has a similar clinical expediency and possesses more stable maintenance properties. Therefore, it could be used effectively in guided bone regeneration around dehiscence-type defects.

Keywords

References

  1. Chiapasco M, Zaniboni M. Clinical outcomes of GBR procedures to correct peri-implant dehiscences and fenestrations: a systematic review. Clin Oral Implants Res 2009;20 Suppl 4:113-23. https://doi.org/10.1111/j.1600-0501.2009.01781.x
  2. Retzepi M, Donos N. Guided Bone Regeneration: biological principle and therapeutic applications. Clin Oral Implants Res 2010; 21:567-76. https://doi.org/10.1111/j.1600-0501.2010.01922.x
  3. Locci P, Calvitti M, Belcastro S, Pugliese M, Guerra M, Marinucci L, et al. Phenotype expression of gingival fibroblasts cultured on membranes used in guided tissue regeneration. J Periodontol 1997;68:857-63. https://doi.org/10.1902/jop.1997.68.9.857
  4. Schwarz F, Rothamel D, Herten M, Wustefeld M, Sager M, Ferrari D, et al. Immunohistochemical characterization of guided bone regeneration at a dehiscence-type defect using different barrier membranes: an experimental study in dogs. Clin Oral Implants Res 2008;19:402-15. https://doi.org/10.1111/j.1600-0501.2007.01486.x
  5. Behring J, Junker R, Walboomers XF, Chessnut B, Jansen JA. Toward guided tissue and bone regeneration: morphology, attachment, proliferation, and migration of cells cultured on collagen barrier membranes. A systematic review. Odontology 2008;96:1-11. https://doi.org/10.1007/s10266-008-0087-y
  6. Schwarz F, Rothamel D, Herten M, Sager M, Becker J. Angiogenesis pattern of native and cross-linked collagen membranes: an immunohistochemical study in the rat. Clin Oral Implants Res 2006; 17:403-9. https://doi.org/10.1111/j.1600-0501.2005.01225.x
  7. Sela MN, Kohavi D, Krausz E, Steinberg D, Rosen G. Enzymatic degradation of collagen-guided tissue regeneration membranes by periodontal bacteria. Clin Oral Implants Res 2003;14:263-8. https://doi.org/10.1034/j.1600-0501.2003.140302.x
  8. Jung RE, Fenner N, Hammerle CH, Zitzmann NU. Long-term outcome of implants placed with guided bone regeneration (GBR) using resorbable and non-resorbable membranes after 12-14 years. Clin Oral Implants Res 2013;24:1065-73. https://doi.org/10.1111/j.1600-0501.2012.02522.x
  9. Drexler JW, Powell HM. Dehydrothermal crosslinking of electrospun collagen. Tissue Eng Part C Methods 2011;17:9-17. https://doi.org/10.1089/ten.tec.2009.0754
  10. Schwarz F, Sager M, Rothamel D, Herten M, Sculean A, Becker J. Use of native and cross-linked collagen membranes for guided tissue and bone regeneration. Schweiz Monatsschr Zahnmed 2006; 116:1112-23.
  11. Charulatha V, Rajaram A. Influence of different crosslinking treatments on the physical properties of collagen membranes. Biomaterials 2003;24:759-67. https://doi.org/10.1016/S0142-9612(02)00412-X
  12. Olde Damink LH, Dijkstra PJ, van Luyn MJ, van Wachem PB, Nieuwenhuis P, Feijen J. Cross-linking of dermal sheep collagen using a water-soluble carbodiimide. Biomaterials 1996;17:765-73. https://doi.org/10.1016/0142-9612(96)81413-X
  13. Zahedi S, Bozon C, Brunel G. A 2-year clinical evaluation of a diphenylphosphorylazide-cross-linked collagen membrane for the treatment of buccal gingival recession. J Periodontol 1998;69: 975-81. https://doi.org/10.1902/jop.1998.69.9.975
  14. Becker J, Al-Nawas B, Klein MO, Schliephake H, Terheyden H, Schwarz F. Use of a new cross-linked collagen membrane for the treatment of dehiscence-type defects at titanium implants: a prospective, randomized-controlled double-blinded clinical multicenter study. Clin Oral Implants Res 2009;20:742-9. https://doi.org/10.1111/j.1600-0501.2008.01689.x
  15. Annen BM, Ramel CF, Hammerle CH, Jung RE. Use of a new cross-linked collagen membrane for the treatment of peri-implant dehiscence defects: a randomised controlled double-blinded clinical trial. Eur J Oral Implantol 2011;4:87-100.
  16. Marzec E, Pietrucha K. The effect of different methods of cross-linking of collagen on its dielectric properties. Biophys Chem 2008;132:89-96. https://doi.org/10.1016/j.bpc.2007.10.012
  17. Haugh MG, Jaasma MJ, O'Brien FJ. The effect of dehydrothermal treatment on the mechanical and structural properties of collagen-GAG scaffolds. J Biomed Mater Res A 2009;89:363-9.
  18. Rothamel D, Benner M, Fienitz T, Happe A, Kreppel M, Nickenig HJ, et al. Biodegradation pattern and tissue integration of native and cross-linked porcine collagen soft tissue augmentation matrices - an experimental study in the rat. Head Face Med 2014; 10:10. https://doi.org/10.1186/1746-160X-10-10
  19. Morris K. Revising the Declaration of Helsinki. Lancet 2013;381: 1889-90. https://doi.org/10.1016/S0140-6736(13)60951-4
  20. Stoecklin-Wasmer C, Rutjes AW, da Costa BR, Salvi GE, Juni P, Sculean A. Absorbable collagen membranes for periodontal regeneration: a systematic review. J Dent Res 2013;92:773-81. https://doi.org/10.1177/0022034513496428
  21. Gholami GA, Najafi B, Mashhadiabbas F, Goetz W, Najafi S. Clinical, histologic and histomorphometric evaluation of socket preservation using a synthetic nanocrystalline hydroxyapatite in comparison with a bovine xenograft: a randomized clinical trial. Clin Oral Implants Res 2012;23:1198-204. https://doi.org/10.1111/j.1600-0501.2011.02288.x
  22. Faul F, Erdfelder E, Buchner A, Lang AG. Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses. Behav Res Methods 2009;41:1149-60. https://doi.org/10.3758/BRM.41.4.1149
  23. Lorenzoni M, Pertl C, Polansky RA, Jakse N, Wegscheider WA. Evaluation of implants placed with barrier membranes. A restrospective follow-up study up to five years. Clin Oral Implants Res 2002;13:274-80. https://doi.org/10.1034/j.1600-0501.2002.130306.x
  24. Donos N, Kostopoulos L, Karring T. Alveolar ridge augmentation using a resorbable copolymer membrane and autogenous bone grafts. An experimental study in the rat. Clin Oral Implants Res 2002;13:203-13. https://doi.org/10.1034/j.1600-0501.2002.130211.x
  25. Moses O, Pitaru S, Artzi Z, Nemcovsky CE. Healing of dehiscence-type defects in implants placed together with different barrier membranes: a comparative clinical study. Clin Oral Implants Res 2005;16:210-9. https://doi.org/10.1111/j.1600-0501.2004.01100.x
  26. Friedmann A, Strietzel FP, Maretzki B, Pitaru S, Bernimoulin JP. Observations on a new collagen barrier membrane in 16 consecutively treated patients. Clinical and histological findings. J Periodontol 2001;72: 1616-23. https://doi.org/10.1902/jop.2001.72.11.1616
  27. Turkyilmaz I, McGlumphy EA. Influence of bone density on implant stability parameters and implant success: a retrospective clinical study. BMC Oral Health 2008;8:32. https://doi.org/10.1186/1472-6831-8-32
  28. Owens KW, Yukna RA. Collagen membrane resorption in dogs: a comparative study. Implant Dent 2001;10:49-58. https://doi.org/10.1097/00008505-200101000-00016
  29. Rothamel D, Schwarz F, Sculean A, Herten M, Scherbaum W, Becker J. Biocompatibility of various collagen membranes in cultures of human PDL fibroblasts and human osteoblast-like cells. Clin Oral Implants Res 2004;15:443-9. https://doi.org/10.1111/j.1600-0501.2004.01039.x
  30. Verissimo DM, Leitao RF, Ribeiro RA, Figueiro SD, Sombra AS, Goes JC, et al. Polyanionic collagen membranes for guided tissue regeneration: Effect of progressive glutaraldehyde cross-linking on biocompatibility and degradation. Acta Biomater 2010;6:4011-8. https://doi.org/10.1016/j.actbio.2010.04.012
  31. Tierney CM, Haugh MG, Liedl J, Mulcahy F, Hayes B, O'Brien FJ. The effects of collagen concentration and crosslink density on the biological, structural and mechanical properties of collagen-GAG scaffolds for bone tissue engineering. J Mech Behav Biomed Mater 2009;2:202-9. https://doi.org/10.1016/j.jmbbm.2008.08.007
  32. Weadock KS, Miller EJ, Bellincampi LD, Zawadsky JP, Dunn MG. Physical crosslinking of collagen fibers: comparison of ultraviolet irradiation and dehydrothermal treatment. J Biomed Mater Res 1995;29:1373-9. https://doi.org/10.1002/jbm.820291108
  33. Cornwell KG, Lei P, Andreadis ST, Pins GD. Crosslinking of discrete self-assembled collagen threads: Effects on mechanical strength and cell-matrix interactions. J Biomed Mater Res A 2007;80:362-71.
  34. Delgado LM, Bayon Y, Pandit A, Zeugolis DI. To cross-link or not to cross-link? Cross-linking associated foreign body response of collagen-based devices. Tissue Eng Part B Rev 2015;21:298-313. https://doi.org/10.1089/ten.teb.2014.0290
  35. Junker R, Dimakis A, Thoneick M, Jansen JA. Effects of implant surface coatings and composition on bone integration: a systematic review. Clin Oral Implants Res 2009;20 Suppl 4:185-206. https://doi.org/10.1111/j.1600-0501.2009.01777.x

Cited by

  1. Biodegradable Polymer Membranes Applied in Guided Bone/Tissue Regeneration: A Review vol.8, pp.4, 2015, https://doi.org/10.3390/polym8040115
  2. Osteogenesis of peri-implant dehiscence defects using a barrier membrane : vol.8, pp.2, 2015, https://doi.org/10.1097/01.omx.0000516505.38916.a1
  3. Physiochemical properties and resorption progress of porcine skin-derived collagen membranes: In vitro and in vivo analysis vol.37, pp.2, 2018, https://doi.org/10.4012/dmj.2017-065
  4. Assessment of clinical and radiographic outcomes of guided bone regeneration with dehydrothermally cross-linked collagen membrane around peri-implant dehiscence defects: Results from a 3-year randomiz vol.43, pp.1, 2015, https://doi.org/10.21851/obr.43.01.201903.8
  5. Dental alloplastic bone substitutes currently available in Korea vol.45, pp.2, 2015, https://doi.org/10.5125/jkaoms.2019.45.2.51
  6. Soft tissue augmentation with volume stable collagen matrix: Two cases report vol.43, pp.2, 2015, https://doi.org/10.21851/obr.43.02.201906.161
  7. Core Ossification of Bone Morphogenetic Protein-2-Loaded Collagenated Bone Mineral in the Sinus vol.27, pp.13, 2015, https://doi.org/10.1089/ten.tea.2020.0151