Factors influencing Cognitive Function in Women Cancer Patients Receiving Chemotherapy

항암화학요법을 받는 여성암 환자의 인지기능에 영향을 미치는 요인

  • Received : 2014.12.02
  • Accepted : 2015.02.02
  • Published : 2015.02.20

Abstract

Objective : The purpose of this study was to examine the level of the cognitive function, and to identify the influencing factors on cognitive function in women cancer patients receiving chemotherapy. This study attempted to provide basic data useful to development of nursing intervention and improve the quality of life in women cancer patients. Methods : As a cross-sectional descriptive study, women with receiving chemotherapy above one cycle were recruited. One hundred and twenty-five women cancer patients who met the study criteria agreed to participate in the study. The questionnaire set consisted of cognitive function, quality of life, depression, anxiety and information on demographic and clinical characteristics. Results : There was no statistically significant difference in clinical characteristics according to the cognitive function. The cognitive function was higher the more low age (F=9.937, p<.001), and the more high education level (F=12.332, p<.001). Multiple regression analysis showed the predictors were significantly related to cognitive function. age, education, and the number of chemotherapy explained 31.8% of the cognitive function. Conclusions : This result of this study provides basic information about factors influencing cognitive function, although study findings are insufficient in explaining related variables among women cancer patients. Even though women cancer patients were receiving chemotherapy, this study showed that the level of cognitive function was high. In order to receive better results and findings the period decreasing cognitive function, further studies are need to measure cognitive function according to the passage of time during or after chemotherapy.

Keywords

References

  1. 국가암 정보센터, 2012.
  2. 김경혜, 정복례, 김경덕, 변혜선, 최은희, 조은정(2012). 항암화학요법을 받은 유방암 환자의 인지기능. 종양간호학회지, 12(1), 1-11.
  3. Varsha Dutta(2011). Chemotherapy, neurotoxicity, and cognitive changes in breast cancer. Journal of Cancer Research and Therapeutics, 7(3), 264-269. https://doi.org/10.4103/0973-1482.87008
  4. Ferguson R, Ahles T(2003). Low neuropsychologic performance among adult cancer survivors treated with chemotherapy. Curr Neur Neurosci Rep, 3, 215-222. https://doi.org/10.1007/s11910-003-0081-2
  5. Brezden C, Phillips K, AbdolellM, Bunston T, Tannock I(2000). Cognitive function in breast cancer patients receiving adjuvant chemotherapy. Journal of Clinical Oncology, 18, 2695. https://doi.org/10.1200/JCO.2000.18.14.2695
  6. Tchen N, Juffs H, Downie F et al. Cognitive function, fatigue and menopausal symptoms in women receiving adjuvant chemotherapy for breast cancer. Wom Oncol Rev, 4, 123-124.
  7. Schagen S, Muller M, Boogerd W, Mellenbergh G, van Dam F(2006). Change in Cognitive Function After Chemotherapy. A Prospective Longitudinal Study in Breast Cancer Patients, Oxford University Press: Oxford, 1742-1745.
  8. Ahles T, Saykin A (2001). Cognitive effects of standard-dose chemotherapy in patients with cancer. Cancer Invest, 19, 812-820. https://doi.org/10.1081/CNV-100107743
  9. Tannock IF, Ahles TA, Ganz PA, Van Dam FS(2004). Cognitive impairment associated with chemotherapy for cancer: report of a workshop. J Clin Oncol, 22, 2233-2239. https://doi.org/10.1200/JCO.2004.08.094
  10. Vardy J, Wefel JS, Ahles T, Tannock IF, Schagen SB(2008). Cancer and cancertherapy related cognitive dysfunction: an international perspective from the Venice cognitive workshop. Ann Oncol, 19, 623-9.
  11. Jansen CE, Cooper BA, Dodd MJ, Miaskowski CA(2010). A prospective longitudinal study of chemotherapy-induced cognitive changes in breast cancer patients. Support Care Cancer, 19, 1647-1656.
  12. Jansen CE, Dodd MJ, Miaskowski CA, Dowling GA, Kramer J(2008). Preliminary results of a longitudinal study of changes in cognitive function in breast cancer patients undergoing chemotherapy with doxorubicin and cyclophosphamide. Psycho-Oncology, 17, 1189-1195. https://doi.org/10.1002/pon.1342
  13. Schagen SB, Muller MJ, Boogerd W, Rosenbrand RM, van Rhijin D, rodenhuis S, van Dam FSAM(2002). Late effects of adjuvant chemotherapy on cognitive function: a follow-up study in breast cancer patients. Ann Oncol, 13, 1387-1397. https://doi.org/10.1093/annonc/mdf241
  14. Robert J. Ferguson, Brenna C, McDonald, Michael A. Rocque, Chalotte T. Furstenberg, Susan Horrigan, Tim A. Ahles, Andrew J. Saykin(2012). Development of CBT for chemotherapy-related cognitive change: results of a waitlist control trial. Psycho-Oncology, 21, 176-186. https://doi.org/10.1002/pon.1878
  15. Jansen, C., Miaskowski, C., Dodd, M., Dowling, G., & Kramer, J. (2005). Potential mechanisms for chemotherapy-induced impairments in cognitive function. Oncology Nursing Forum, 32(6), 1151-1163. https://doi.org/10.1188/05.ONF.1151-1163
  16. Andrykowski MA, Burris JL, Walsh E, Small BJ, Jacobsen PB, Attitudes toward information about genetic risk for cognitive impairment after cancer chemotherapy: breast cancer survivors compared with healthy controls. J Clin Oncol, 28, 3442-3447.
  17. Catherine Jansen (2009). Chemotherapy and Biotherapy Guidelines and Recommendations for Practice. 3rdedition. ONS Publishing Division, 284-285.
  18. Matsuda T, Takayama T, Tashioro M, Nakamura Y, Ohash Y, Shimozuma K(2005). Mild cognitive impairment after adjuvant chemotherapy in breast cancer patients evaluation of appropriate research design and methology to measure symptoms. Breast Cancer, 12, 279-287. https://doi.org/10.2325/jbcs.12.279
  19. Catherine EJ, Christine A, Marilyn JD, Glenna AD, Joel K(2008). Preliminary results of a longitudinal study of changes in cognitive function in breast cancer patients undergoing chemotherapy with doxorubicin and cyclophosphamide. Psycho-Oncology, 17, 1189-1198. https://doi.org/10.1002/pon.1342
  20. Van Dam FS, Schagen SB, Muller MJ, Boogerd W, Wall E, Droogleever Fortuyn ME, et al(1998). Impairment of cognitive function in women receiving adjuvant treatment for high-risk breast cancer: High-dose versus standard-dose chemotherapy. J Natl Cancer Inst, 90, 210-218. https://doi.org/10.1093/jnci/90.3.210
  21. Schagen SB, Enny D, Frits SA, Van Dam FS(2009). The influence of priming and preexisting knowledge of chemotherapy associated cognitive complaints breast cancer patients. Psycho-Oncology, 18, 674-678. https://doi.org/10.1002/pon.1454
  22. 김경덕, 정복례, 김경혜, 변혜선, 최은희(2011). 항암화학요법으로 인한 유방암 환자의 인지기능 측정도구 사용 실태 분석. 종양간호학회지, 11(3), 179-185.
  23. 최은희, 정복례, 김경덕, 김경혜, 변혜선(2011). 항암화학요법 유방암환자의 인지기능 증진 중재에 대한 논문 분석. 종양간호학회지, 11(1), 26-32.
  24. 정복례, 변혜선, 김경덕, 김경혜, 최은희(2012). 항암화학요법을 받은 유방암 여성의 인지기능변화 경험. 여성건강간호학회지, 18(1), 1-16.
  25. 정복례, 조은정(2012). 화학요법을 받는 유방암 환자의 인지기능장애 관련 요인. 종양간호연구, 12(3), 221-229.
  26. 강연욱, 나덕렬, 한승혜(1997). 치매환자들 을 대상으로 한 K-MMSE의 타당도 연구. 대한신경학회지, 15(2), 300-308.
  27. 이은현(2007). 한국 암 특이형 삶의 질 측정도구(C-QOL) 개발 및 평가. 대한간호학회지, 37(3), 324-333.
  28. Zigmond AS, Snaith RP(1983). The Hospital Anxiety and Depression Scale. Acte Psychiatr Scand, 67, 361-370. https://doi.org/10.1111/j.1600-0447.1983.tb09716.x
  29. 오세만, 민경준, 박두병(1999). 병원 불안-우울 척도에 관한 표준화 연구. 신경정신의학, 38(2), 289-296.
  30. Hedayati F., Alinaghizadeh H., Schedin A., Nyman H., Albertsson M(2011). Effects of adjuvant treatment on cognitive function in women with early breast cancer. Eur J Oncol Nurs, 9, 1-8.
  31. Quesnel C., Savard J., Ivers H.(2009). Cognitive impairments associated with breast cancer treatments: results from a longitudinal study. Breast cancer Res Treat, 116(1), 113-123. https://doi.org/10.1007/s10549-008-0114-2
  32. 노주희, 김성렬, 강경선, 권용순(2014). 항암화학요법을 받는 부인암 환자의 영양장애, 우울 정도와 삶의 질과의 관계. 여성건강간호학회지, 20(2), 117-125.
  33. Svetlana P., Yifat F., Julie C., David B.(2011). Analysis of memory deficits following chemotherapy in breast cancer survivors: evidence from doors and people test. J of Psychosocial Oncology, 29, 499-514. https://doi.org/10.1080/07347332.2011.600751
  34. Ahles TA., Saykin AJ(2002). Breast cancer chemotherapy-related cognitive dysfunction. Clin Breast Cancer, 3, 84-90. https://doi.org/10.3816/CBC.2002.s.018