Parasites, Hosts and Diseases

  • 제53권3호
  • /
  • Pages.329-333
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  • 2015
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  • 2982-5164(pISSN)
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  • 1738-0006(eISSN)
대한기생충학·열대의학회 (The Korea Society for Parasitology and Tropical Medicine)
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A Rare Human Case of Dirofilaria repens Infection in the Subcutaneous Posterior Thorax with Molecular Identification

  • Le, Tran Anh (Department of Parasitology, Vietnam Military Medical University) ;
  • Vi, Thuat Thang (Department of Pathology, Hospital 103, Vietnam Military Medical University) ;
  • Nguyen, Khac Luc (Department of Parasitology, Vietnam Military Medical University) ;
  • Le, Thanh Hoa (Immunology Department, Institute of Biotechnology, Vietnam Academy of Science and Technology)
  • 투고 : 2015.03.17
  • 심사 : 2015.05.23
  • 발행 : 2015.06.30
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초록

The emergence of dirofilarial infections in Asia including Vietnam is a clinically significant threat to the community. We here report a rare case of subcutaneous Dirofilaria repens infection on the posterior thoracic wall in a young woman presenting a painful, itchy, and palpable nodule. The adult worm was identified by mitochondrial cox1 and nuclear ITS-2 sequence determination. The diagnosis was additionally confirmed by 16S rRNA sequencing of the endosymbiont Wolbachia pipientis commonly co-existing with D. repens. This is a rare case of subcutaneous human infection on the posterior thoracic region caused by D. repens.

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참고문헌

  1. Simon F, Siles-Lucas M, Morchon R, Gonzalez-Miguel J, Mellado I, Carreton E, Montoya-Alonso JA. Human and animal dirofilariasis: the emergence of a zoonotic mosaic. Clin Microbiol Rev 2012; 25: 507-544. https://doi.org/10.1128/CMR.00012-12
  2. Casiraghi M, Bain O, Guerrero R, Martin C, Pocacqua V, Gardner SL, Franceschi A, Bandi C. Mapping the presence of Wolbachia pipientis on the phylogeny of filarial nematodes: evidence for symbiont loss during evolution. Int J Parasitol 2004; 34: 191-203. https://doi.org/10.1016/j.ijpara.2003.10.004
  3. Cancrini G, Scaramozzino P, Gabrielli S, Di Paolo M, Toma L, Romi R. Aedes albopictus and Culex pipiens implicated as natural vectors of Diroflaria repens in central Italy. J Med Entomol 2007; 44: 1064-1066.
  4. Dang TC, Nguyen TH, Do TD, Uga S, Morishima Y, Sugiyama H, Yamasaki H. A human case of subcutaneous dirofilariasis caused by Dirofilaria repens in Vietnam: histologic and molecular confirmation. Parasitol Res 2010; 107: 1003-1007. https://doi.org/10.1007/s00436-010-1961-4
  5. De NV, Le TH, Chai JY. Dirofilaria repens in Vietnam: detection of 10 eye and subcutaneous tissue infection cases identified by morphology and molecular methods. Korean J Parasitol 2012; 50: 137-141. https://doi.org/10.3347/kjp.2012.50.2.137
  6. Sathyan P, Manikandan P, Bhaskar M, Padma S, Singh G, Appalaraju B. Subcutaneus infection by Dirofilaria repens. Indian J Med Microbiol 2006; 24: 61-62. https://doi.org/10.4103/0255-0857.19899
  7. Rishniw M, Barr SC, Simpson KW, Frongillo MF, Franz M, Dominguez Alpizar JL. Discrimination between six species of canine microfilariae by a single polymerase chain reaction. Vet Parasitol 2006; 135: 303-314. https://doi.org/10.1016/j.vetpar.2005.10.013
  8. Tamura K, Peterson D, Peterson N, Stecher G, Nei M, Kumar S. MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods. Mol Biol Evol 2011; 28: 2731-2739. https://doi.org/10.1093/molbev/msr121
  9. Khoramnia R, Wegner A. Images in clinical medicine: subconjunctival Dirofilaria repens. N Engl J Med 2010; 363: e37. https://doi.org/10.1056/NEJMicm1003006
  10. Sviben M, Mestrovic T, Nemer K, Bartulovic KP, Skara R, Galinovic GM. Dirofilaria repens as a cause of subconjunctival infection in a 77-years old female patient from Croatia-a case report. Coll Antropol 2013; 37: 995-997.
  11. Foroulis CN, Khaldi L, Desimonas N, Kalafati G. Pulmonary dirofilariasis mimicking lung tumor with chest wall and mediastinal invasion. Thorac Cardiovasc Surg 2005; 53: 173-175. https://doi.org/10.1055/s-2004-830567
  12. Mulanovich EA, Mulanovich VE, Rolston KV. A case of Dirofilaria pulmonary infection coexisting with lung cancer. J Infect 2008; 56: 241-243. https://doi.org/10.1016/j.jinf.2008.01.007
  13. Pozgain Z, Dulic G, Sego K, Blazekovic R. Live Dirofilaria immitis found during coronary artery bypass grafting procedure. Eur J Cardiothorac Surg 2014; 46: 134-136. https://doi.org/10.1093/ejcts/ezt496
  14. Maltezos ES, Sivridis EL, Giatromanolaki AN, Simopoulos CE. Human subcutaneous dirofilariasis: a report of three cases manifesting as breast or axillary nodules. Scott Med J 2002; 47: 86-88. https://doi.org/10.1177/003693300204700404
  15. Pampiglione S, Fioravanti ML, Piccolotti D, Pizzicannella G, Reale D. Human dirofilariasis in Italy: a new case in the spermatic cord. Parasitologia 2002; 44: 93-96.
  16. Genchi C, Kramer LH, Rivasi F. Dirofilarial infection in Europe. Vector-borne Zoonot Dis 2011; 11: 1307-1317. https://doi.org/10.1089/vbz.2010.0247
  17. Leccia N, Patouraux S, Carpentier X, Boissy C, Del Giudice P, Parks S, Michiels JF, Ambrosetti D. Pseudo-tumor of the scrotum, a rare clinical presentation of dirofilariasis: a report of two autochthonous cases due to Dirofilaria repens. Pathog Glob Health 2012; 106: 370-372. https://doi.org/10.1179/2047773212Y.0000000029
  18. Hermosilla C, Pantchev N, Dyachenko V, Gutmann M, Bauer C. First autochthonous case of canine ocular Dirofilaria repens infection in Germany. Vet Rec 2006; 158: 134-135. https://doi.org/10.1136/vr.158.4.134
  19. Grandi G, Zivicnjak T, Beck R. Pathogenesis of Dirofilaria spp. infection. In Cringoli G (ed), Mappe Parasitologiche, Vol. 8. Naples, Italy. Universita degli Studi di Napoli Federico II. 2007, pp 59-66.
  20. Dantas-Torres F, Otranto D. 2013. Dirofilariosis in the Americas: a more virulent Dirofilaria immitis? Parasit Vectors 2013; 6: 288. https://doi.org/10.1186/1756-3305-6-288
  21. Chan CC, Kermanshahi MS, Mathew B, England RJ. A rare case of Dirofilaria repens infection. J Laryngol Otol 2013; 127: 607-609. https://doi.org/10.1017/S0022215113001060
  22. Dissanaike AS, Ramalingam S, Fong A, Pathmayokan S, Thomas V, Kan SP. Filaria in the vitreous of the eye of man in peninsular Malaysia. Am J Trop Med Hyg 1977; 26: 1143-1147. https://doi.org/10.4269/ajtmh.1977.26.1143

피인용 문헌

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  2. The Mitochondrial Genomes of the Zoonotic Canine Filarial Parasites Dirofilaria ( Nochtiella ) repens and Candidatus Dirofilaria (Nochtiella) Honkongensis Provide Evidence for Presence of Crypti vol.10, pp.10, 2015, https://doi.org/10.1371/journal.pntd.0005028
  3. The Complexity of Zoonotic Filariasis Episystem and Its Consequences: A Multidisciplinary View vol.2017, pp.None, 2015, https://doi.org/10.1155/2017/6436130
  4. Molecular characterization of human Dirofilaria isolates from Kerala vol.146, pp.4, 2015, https://doi.org/10.4103/ijmr.ijmr_1425_15