Parasites, Hosts and Diseases

The Korea Society for Parasitology and Tropical Medicine (대한기생충학·열대의학회)
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Relationship between Antibody-Positive Rate against Plasmodium vivax Circumsporozoite Protein and Incidence of Malaria

  • Lee, Hyeong-Woo (Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida) ;
  • Kang, Yoon-Joong (Department of Biomedical Science, Jungwon University) ;
  • Cho, Shin-Hyeong (Division of Malaria and Parasitic Diseases, National Institute of Health, Korea Centers for Disease Control and Prevention) ;
  • Na, Byoung-Kuk (Department of Parasitology and Tropical Medicine and Institute of Health Sciences, Gyeongsang National University School of Medicine) ;
  • Pak, Jhang Ho (Asan Institute for Life Sciences, University of Ulsan College of Medicine Asan Medical Center) ;
  • Nam, Ho-Woo (Department of Parasitology, College of Medicine, Catholic University of Korea) ;
  • Park, Yun-Kyu (Department of Parasitology and Tropical Medicine and Inha Research Institute for Medical Sciences, Inha University School of Medicine) ;
  • Sohn, Youngjoo (Department of Anatomy, College of Korean Medicine, Institute of Korean Medicine, Kyung Hee University) ;
  • Kim, Tong-Soo (Department of Parasitology and Tropical Medicine and Inha Research Institute for Medical Sciences, Inha University School of Medicine)
  • Received : 2014.09.23
  • Accepted : 2015.02.25
  • Published : 2015.04.30
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Abstract

The relationship between anti-Plasmodium vivax circumsporozoite protein (CSP) antibody levels and the prevalence of malaria in epidemic areas of South Korea was evaluated. Blood samples were collected from inhabitants of Gimpo-si (city), Paju-si, and Yeoncheon-gun (county) in Gyeonggi-do (province), as well as Cheorwon-gun in Gangwon-do from November to December 2004. Microscopic examinations were used to identify malaria parasites. ELISA was used to quantitate anti-circumsporozoite protein (CSP) antibodies against P. vivax. A total of 1,774 blood samples were collected. The overall CSP-ELISA-positive rate was 7.7% (n=139). The annual parasite incidences (APIs) in these areas gradually decreased from 2004 to 2005 (1.09 and 0.80, respectively). The positive rate in Gimpo (10.4%, 44/425) was the highest identified by CSP-ELISA. The highest API was found in Yeoncheon, followed by Cheorwon, Paju, and Gimpo in both years. The positive rates of CSP-ELISA were closely related to the APIs in the study areas. These results suggest that seroepidemiological studies based on CSP may be helpful in estimating the malaria prevalence in certain areas. In addition, this assay can be used to establish and evaluate malaria control and eradication programs in affected areas.

Keywords

References

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