Parasites, Hosts and Diseases

The Korea Society for Parasitology and Tropical Medicine (대한기생충학·열대의학회)
권호 표지
DOI QR코드

DOI QR Code

Comorbid Gastric Adenocarcinoma and Gastric and Duodenal Strongyloides stercoralis Infection: A Case Report

  • Seo, An Na (Department of Pathology, Kyungpook National University Medical Center, Kyungpook National University School of Medicine) ;
  • Goo, Youn-Kyoung (Department of Parasitology and Tropical Medicine, Kyungpook National University School of Medicine) ;
  • Chung, Dong-Il (Department of Parasitology and Tropical Medicine, Kyungpook National University School of Medicine) ;
  • Hong, Yeonchul (Department of Parasitology and Tropical Medicine, Kyungpook National University School of Medicine) ;
  • Kwon, Ohkyoung (Gastric Cancer Center, Kyungpook National University Medical Center, Kyungpook National University School of Medicine) ;
  • Bae, Han-Ik (Department of Pathology, Kyungpook National University Medical Center, Kyungpook National University School of Medicine)
  • Received : 2014.06.05
  • Accepted : 2014.10.02
  • Published : 2015.02.28
Download PDF
⟨ Previous Next ⟩

Abstract

Strongyloides stercoralis can cause systemic infection, termed strongyloidiasis, and gastrointestinal ulcer disease in immunocompromised patients. However, to our knowledge, there are no reported cases of comorbid gastric adenocarcinoma and S. stercoralis infection. Here, we report a case of an 81-year-old Korean man who presented with S. stercoralis infection coexisting with early gastric adenocarcinoma (T1aN0M0). S. stercoralis eggs, rhabditiform larvae, and adult females were observed in normal gastric and duodenal crypts. They were also observed in atypical glands representative of adenocarcinoma and adenoma. Preliminary laboratory tests revealed mild neutrophilic and eosinophilic leukocytosis. A routine stool test failed to detect rhabditiform larvae in the patient's fecal sample; however, S. stercoralis was identified by PCR amplification and 18S rRNA sequencing using genomic DNA extracted from formalin-fixed paraffin-embedded tissues. Postoperatively, the patient had a persistent fever and was treated with albendazole for 7 days, which alleviated the fever. The patient was followed-up by monitoring and laboratory testing for 4 months postoperatively, and no abnormalities were observed thus far. The fact that S. stercoralis infection may be fatal in immunocompromised patients should be kept in mind when assessing high-risk patients.

Keywords

References

  1. Altintop L, Cakar B, Hokelek M, Bektas A, Yildiz L, Karaoglanoglu M. Strongyloides stercoralis hyperinfection in a patient with rheumatoid arthritis and bronchial asthma: a case report. Ann Clin Microbiol Antimicrob 2010; 9: 27. https://doi.org/10.1186/1476-0711-9-27
  2. Anamnart W, Pattanawongsa A, Intapan PM, Morakote N, Janwan P, Maleewong W. Detrimental effect of water submersion of stools on development of Strongyloides stercoralis. PLoS One 2013; 8: e82339. https://doi.org/10.1371/journal.pone.0082339
  3. Sheth S, Asslo F, Hallit R, Sison R, Afridi M, Spira R, Depasquale J, Slim J, Boghossian J. Strongyloidiasis: the cause of multiple gastrointestinal ulcers in an immunocompetent individual. Case Rep Med 2014; 2014: 346256.
  4. Moghaddassani H, Mirhendi H, Hosseini M, Rokni M, Mowlavi G, Kia E. Molecular diagnosis of Strongyloides stercoralis infection by PCR detection of specific DNA in human stool samples. Iran J Parasitol 2011; 6: 23-30.
  5. Sitta RB, Malta FM, Pinho JR, Chieffi PP, Gryschek RC, Paula FM. Conventional PCR for molecular diagnosis of human strongyloidiasis. Parasitology 2014; 141: 716-721. https://doi.org/10.1017/S0031182013002035
  6. Kishimoto K, Hokama A, Hirata T, Ihama Y, Nakamoto M, Kinjo N, Kinjo F, Fujita J. Endoscopic and histopathological study on the duodenum of Strongyloides stercoralis hyperinfection. World J Gastroenterol 2008; 14(11): 1768-1773. https://doi.org/10.3748/wjg.14.1768
  7. Kim J, Joo HS, Kim DH, Lim H, Kang YH, Kim MS. A case of gastric strongyloidiasis in a Korean patient. Korean J Parasitol 2003; 41: 63-67. https://doi.org/10.3347/kjp.2003.41.1.63
  8. Buonfrate D, Requena-Mendez A, Angheben A, Munoz J, Gobbi F, Van Den Ende J, Bisoffi Z. Severe strongyloidiasis: a systematic review of case reports. BMC Infect Dis 2013; 13: 78. https://doi.org/10.1186/1471-2334-13-78
  9. Segarra-Newnham M. Manifestations, diagnosis, and treatment of Strongyloides stercoralis infection. Ann Pharmacother 2007; 41: 1992-2001. https://doi.org/10.1345/aph.1K302

Cited by

  1. Carcinogenesis associated with parasites other than Schistosoma, Opisthorchis and Clonorchis: A systematic review vol.138, pp.12, 2016, https://doi.org/10.1002/ijc.30028
  2. Strongyloidiasis Current Status with Emphasis in Diagnosis and Drug Research vol.2017, pp.None, 2015, https://doi.org/10.1155/2017/5056314
  3. Colorectal Cancer Associated with Strongyloides stercoralis Colitis vol.4, pp.1, 2015, https://doi.org/10.14309/crj.2017.104
  4. Parasite Infection, Carcinogenesis and Human Malignancy vol.15, pp.None, 2015, https://doi.org/10.1016/j.ebiom.2016.11.034
  5. Colorectal Cancer Related to Chronic Strongyloides stercoralis Infection vol.2020, pp.None, 2020, https://doi.org/10.1155/2020/8886460
  6. Bacterial and Parasitic Pathogens as Risk Factors for Cancers in the Gastrointestinal Tract: A Review of Current Epidemiological Knowledge vol.12, pp.None, 2021, https://doi.org/10.3389/fmicb.2021.790256