Journal of Yeungnam Medical Science
- 제32권2호
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- Pages.127-131
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- 2015
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- 2799-8010(eISSN)
DOI QR Code
An overlap syndrome of Churg-Strauss syndrome and rheumatoid arthritis
- Bae, Seung Il (Division of Rheumatology, Department of Internal Medicine, College of Medicine, Yeungnam University) ;
- Jang, Jong Geol (Division of Rheumatology, Department of Internal Medicine, College of Medicine, Yeungnam University) ;
- Kim, Hun Tae (Division of Rheumatology, Department of Internal Medicine, College of Medicine, Yeungnam University) ;
- Ahn, Hee Yun (Division of Rheumatology, Department of Internal Medicine, College of Medicine, Yeungnam University) ;
- Kim, Min Jung (Division of Rheumatology, Department of Internal Medicine, College of Medicine, Yeungnam University) ;
- Kim, Hyun Je (Division of Rheumatology, Department of Internal Medicine, College of Medicine, Yeungnam University) ;
- Lee, Choong Ki (Division of Rheumatology, Department of Internal Medicine, College of Medicine, Yeungnam University) ;
- Hong, Young Hoon (Division of Rheumatology, Department of Internal Medicine, College of Medicine, Yeungnam University)
- 투고 : 2014.05.12
- 심사 : 2014.08.28
- 발행 : 2015.12.31
초록
Churg-Strauss syndrome (CSS) is a necrotizing vasculitis with extra-, peri-vascular eosinophilic infiltration. Chronic symmetric polyarthritis with the presence of rheumatoid factor (RF) and anti-cyclic citrullinated peptide antibody are the mainstay of rheumatoid arthritis (RA) diagnosis. Mononeuritis multiplex is a peripheral neuropathy involving more than 2 separate nerve areas. A 62-year-old male patient was referred for left foot drop and polyarthritis of both hands and feet for 4 months. During evaluation, mononeuritis multiplex was detected on nerve conduction study and electromyography tests: vasculitis with neutrophil, eosinophil, and lymphocyte infiltration on peroneal nerve biopsy. A positive response to methacholin and bronchodilator was observed on the pulmonary function test. Radiologic tests showed peri-articular soft tissue swelling and osteopenia on both hand and foot. Marked peripheral eosinophilia, high RF, and positive perinuclear anti-neutrophil cytoplasmic antibody were detected on blood tests. Here, we report on a patient with overlap syndrome of CSS and RA with review of the relevant literature, from which a few references to overlap syndrome of CSS and RA were available.