Biomaterials and Biomechanics in Bioengineering

  • 제2권4호
  • /
  • Pages.225-235
  • /
  • 2015
  • /
  • 2465-9835(pISSN)
  • /
  • 2465-9959(eISSN)
테크노프레스 (Techno-Press)
권호 표지
DOI QR코드

DOI QR Code

Combination of isoproterenol and length oscillations in relaxing porcine airway smooth muscles

  • Al-Jumaily, Ahmed M. (Institute of Biomedical Technologies, Auckland University of Technology) ;
  • Mathur, Meha (Institute of Biomedical Technologies, Auckland University of Technology) ;
  • Cairns, Simeon (Institute of Biomedical Technologies, Auckland University of Technology)
  • 투고 : 2013.10.21
  • 심사 : 2015.08.03
  • 발행 : 2015.12.25
⟨ 이전 논문 다음 논문 ⟩

초록

Treatments for asthma are largely pharmaceutical, with some therapies also utilising alternative breathing techniques. The objective of both medical and alternative methods is to relax contracted airway smooth muscle (ASM). In normal subjects, tidal breathing- and deep inspiration-oscillations are believed to have a bronchodilatory effect. Similarly, application of length oscillations to isolated, contracted ASM also elicits muscle relaxation. As a means of investigating more-effective alternative treatment methods for contracted airways, we analyse the combined effects of bronchodilators and length oscillations on isolated, contracted ASM. The contractile state of the muscle tissue prior to treatment is of primary interest. Thereafter, the effect of applying a combination of small superimposed length oscillations with tidal breathing-like oscillations to ASM is studied alone and in combination with a common bronchodilator, isoproterenol (ISO). This work suggests that relaxation of isolated, contracted ASM following application of combined oscillations and ISO is larger than treatments of either combined oscillations or ISO alone. Further, the observed oscillation-associated relaxation is found to be amplitude- rather than frequency-dependent. This study gives additional insight into the role of oscillations and bronchodilators on contracted airways.

키워드

참고문헌

  1. Al-Jumaily, A.M., Mbikou, P. and Redey, P.R. (2012), "Effect of Length Oscillations on Airway Smooth Muscle Reactivity and Cross-Bridge Cycling", Am. J. Physiol. Lung Cell Mol. Physiol., 303(4), 286-294. https://doi.org/10.1152/ajplung.00100.2012
  2. Davis, M.J. and Hill, M.A. (1999), "Signaling mechanisms underlying the vascular myogenic response", Physiol. Rev., 79(2), 387-423. https://doi.org/10.1152/physrev.1999.79.2.387
  3. Dowell, M.L., Lakser, O.J., Gerthoffer, W.T., Fredberg, J.J., Stelmack, G.L., Halayko, A.J., Solway, J. and Mitchell, R.W. (2005), "Latrunculin B increases force fluctuation-induced relengthening of AChcontracted, isotonically shortened canine tracheal smooth muscle", J. Appl. Physiol., 98(2), 489-497. https://doi.org/10.1152/japplphysiol.01378.2003
  4. Du, Y., Al-Jumaily, A.M. and Shukla, H. (2007), "Smooth muscle stiffness variation due to external longitudinal oscillations", J. Biomech., 40(14), 3207-3214. https://doi.org/10.1016/j.jbiomech.2007.04.013
  5. Fredberg, J.J., Inouye, D., Miller, B., Nathan, M., Jafari, S., Raboudi, S.H., Butler, J.P., Shore and Sanocka, U. (1997), "Airway smooth muscle, tidal stretches, and dynamically determined contractile states", Am. J. Respiratory Critical Care Med., 156(6), 1752-1759. https://doi.org/10.1164/ajrccm.156.6.9611016
  6. Fredberg, J.J., Inouye, D.S., Mijailovich, S.M. and Butler, J.P. (1999), "Perturbed equilibrium of myosin binding in airway smooth muscle and its implications in bronchospasm", Am. J. Respiratory Critical Care Med., 159(3), 959-967. https://doi.org/10.1164/ajrccm.159.3.9804060
  7. Gump, A., Haughney, L. and Fredberg, J.J. (2001), "Relaxation of activated airway smooth muscle: relative potency of isoproterenol vs. tidal stretch", J. Appl. Physiol., 90(6), 2306-2310. https://doi.org/10.1152/jappl.2001.90.6.2306
  8. Gunst, S.J. (1983), "Contractile force of canine airway smooth muscle during cyclical length changes", J. Appl. Physiol., 55(3), 759-769. https://doi.org/10.1152/jappl.1983.55.3.759
  9. Hedges, J.C., Dechert, M.A., Yamboliev, I.A., Martin, J.L., Hickey, E., Weber, L.A. and Gerthoffer, W.T. (1999), "A role for p38(MAPK)/HSP27 pathway in smooth muscle cell migration", J. Biol. Chem., 274(34), 24211-24219. https://doi.org/10.1074/jbc.274.34.24211
  10. Ijpma, G., Al-Jumaily, A.M., Cairns, S.P. and Sieck, G.C. (2010), "Logarithmic superposition of force response with rapid length changes in relaxed porcine airway smooth muscle", Am. J. Physiol. Lung Cell Mol. Physiol., 299(6), 898-904. https://doi.org/10.1152/ajplung.00023.2010
  11. Ijpma, G., Al-Jumaily, A.M., Cairns, S.P. and Sieck, G.C. (2011), "Myosin filament polymerization and depolymerization in a model of partial length adaptation in airway smooth muscle", J. Appl. Physiol., 111(3), 735-742. https://doi.org/10.1152/japplphysiol.00114.2011
  12. Knox, A.J. and Tattersfield, A. (1995), "Airway smooth muscle relaxation", Thorax, 50(8), 894-901. https://doi.org/10.1136/thx.50.8.894
  13. Lakser, O.J., Lindeman, R.P. and Fredberg, J.J. (2002), "Inhibition of the p38 MAP kinase pathway destabilizes smooth muscle length during physiological loading", Am. J. Physiol. Lung Cell Mol. Physiol., 282(5), L1117-L1121. https://doi.org/10.1152/ajplung.00230.2000
  14. Mehta, D., Tang, D.D., Wu, M.F., Atkinson, S. and Gunst, S.J. (2000), "Role of Rho in Ca2+-insensitive contraction and paxillin tyrosine phosphorylation in smooth muscle", Am. J. Physiol. Cell Physiol., 279(2), C308-C318. https://doi.org/10.1152/ajpcell.2000.279.2.C308
  15. Mehta, D., Wu, M.F. and Gunst, S.J. (1996), "Role of contractile protein activation in the length-dependent modulation of tracheal smooth muscle force", Am. J. Physiol. Cell Physiol., 270(1), C243-252. https://doi.org/10.1152/ajpcell.1996.270.1.C243
  16. Obara, K. and Lanerolle, P. de. (1989), "Isoproterenol attenuates myosin phosphorylation and contraction of tracheal muscle", J. Appl. Physiol., 66(5), 2017-2022. https://doi.org/10.1152/jappl.1989.66.5.2017
  17. Raqeeb, A., Solomon, D., ParA , P.D. and Seow, C.Y. (2010), "Length oscillation mimicking periodic individual deep inspirations during tidal breathing attenuates force recovery and adaptation in airway smooth muscle", J. Appl. Physiol., 109(5), 1476-1482. https://doi.org/10.1152/japplphysiol.00676.2010
  18. Scichilone, N., Permutt, S. and Togias, A. (2001), "The lack of the Bronchoprotective and not the Bronchodilatory ability of deep inspiration is associated with airway Hyperresponsiveness", Am. J. Respiratory Critical Care Med., 163(2), 413-419. https://doi.org/10.1164/ajrccm.163.2.2003119
  19. Shen, X., Wu, M.F., Tepper, R.S. and Gunst, S.J. (1997), "Mechanisms for the mechanical response of airway smooth muscle to length oscillation", J. Appl. Physiol., 83(3), 731-738. https://doi.org/10.1152/jappl.1997.83.3.731
  20. Takuwa, Y., Takuwa, N. and Rasmussen, H. (1988), "The effects of isoproterenol on intracellular calcium concentration", J. Biol. Chem., 263(2), 762-768.
  21. Wang, L., Chitano, P. and Murphy, T.M. (2005), "Length oscillation induces force potentiation in infant guinea pig airway smooth muscle", Am. J. Physiol. Lung Cell. Mole. Physiol., 289(6), 909-915. https://doi.org/10.1152/ajplung.00128.2005
  22. Wang, L., Pare, P.D. and Seow, C.Y. (2000), "Effects of length oscillation on the subsequent force development in swine tracheal smooth muscle", J. Appl. Physiol., 88(6), 2246-2250. https://doi.org/10.1063/1.1288156
  23. Wang, L. and Pare, P.D. (2003), "Deep inspiration and airway smooth muscle adaptation to length change", Respiratory Physiol. Neurobiol., 137(2), 169-178. https://doi.org/10.1016/S1569-9048(03)00145-9