조현병 환자의 언어성 환청과 정신병리의 PANSS 요인들 간의다차원적 관계

Multidimensional Relationship between Auditory Verbal Hallucinations and PANSS Factors of Psychopathology in the Patients with Schizophrenia

  • 신샘이 (동국대학교 일산병원 정신건강의학과) ;
  • 김세현 (동국대학교 일산병원 정신건강의학과) ;
  • 이남영 (동국대학교 일산병원 정신건강의학과) ;
  • 윤탁 (동국대학교 일산병원 정신건강의학과) ;
  • 김용식 (동국대학교 일산병원 정신건강의학과) ;
  • 정인원 (동국대학교 일산병원 정신건강의학과)
  • Shin, Sam Yi (Department of Psychiatry, Dongguk University Ilsan Hospital) ;
  • Kim, Se Hyun (Department of Psychiatry, Dongguk University Ilsan Hospital) ;
  • Lee, Nam Young (Department of Psychiatry, Dongguk University Ilsan Hospital) ;
  • Youn, Tak (Department of Psychiatry, Dongguk University Ilsan Hospital) ;
  • Kim, Yong Sik (Department of Psychiatry, Dongguk University Ilsan Hospital) ;
  • Chung, In Won (Department of Psychiatry, Dongguk University Ilsan Hospital)
  • 투고 : 2015.07.08
  • 심사 : 2015.08.25
  • 발행 : 2015.11.30

초록

Objectives This study was aimed to examine the multidimensional relationship between auditory verbal hallucinations (AVHs) and Positive and Negative Syndrome Scale (PANSS) factors of psychopathology in the patients with schizophrenia. And we explored the differences between assessments to hallucination by the clinicians and patients. Methods 82 patients with schizophrenia who were assessed by the Hamilton Program for Schizophrenia Voices Questionnaire (HPSVQ), Psychotic Symptom Rating Scale-Auditory Hallucination (PSYRATS-AHS), and the PANSS were recruited. Hwang's five-factor model of PANSS, items and total scores of hallucination scales, Kim's and Haddock's factor models of hallucination were applied to examine the correlations between psychopathology and AVHs. AVH-positive patients was 50 in PANSS-HPSVQ group and 24 in PANSS-PSYRATS-AHS. These two groups were separately analyzed. Results Among the five factors of the PANSS, negative and depression/anxiety factors were correlated with the total scores of HPSVQ and PSYRATS-AHS, and positive and autistic preoccupation factors were correlated only with the total score of PSYRATS-AHS. The activation factor was correlated with none of the total scores of HPSVQ/PSYRATS-AHS. These correlation patterns of a total score of HPSVQ/PSYRATS-AHS were same in the emotional factor of HPSVQ and physical factor of PSYRATS-AHS respectively. In the items which showed significant correlations, correlation coefficients of PANSS-PSYRATS-AHS group ranged between 0.406-0.755 and those of PANSS-HPSVQ ranged between 0.283-0.420. Conclusions This study suggested that the psychopathological domains of schizophrenia were differentially correlated with AVHs and the assessment of AVHs by clinicians and patients showed substantial differences which should be integrated into the therapeutic interventions.

키워드

참고문헌

  1. Tsuang MT, Lyons MJ, Faraone SV. Heterogeneity of schizophrenia. Conceptual models and analytic strategies. Br J Psychiatry 1990;156:17-26. https://doi.org/10.1192/bjp.156.1.17
  2. Strauss JS, Carpenter WT Jr. The prognosis of schizophrenia: rationale for a multidimensional concept. Schizophr Bull 1978;4:56-67. https://doi.org/10.1093/schbul/4.1.56
  3. Liddle PF. The multidimensional phenotype of schizophrenia. In: Tamminga CA, editor. Schizophrenia in a molecular age. 1st ed. Washington, DC: American Psychiatric Publishing;1999. p.10-28.
  4. Volavka J, Citrome L. Oral antipsychotics for the treatment of schizophrenia: heterogeneity in efficacy and tolerability should drive decision- making. Expert Opin Pharmacother 2009;10:1917-1928. https://doi.org/10.1517/14656560903061309
  5. Carpenter WT Jr, Kirkpatrick B. The heterogeneity of the longterm course of schizophrenia. Schizophr Bull 1988;14:645-652. https://doi.org/10.1093/schbul/14.4.645
  6. Adityanjee, Aderibigbe YA, Theodoridis D, Vieweg VR. Dementia praecox to schizophrenia: the first 100 years. Psychiatry Clin Neurosci 1999;53:437-448. https://doi.org/10.1046/j.1440-1819.1999.00584.x
  7. Kay SR, Fiszbein A, Opler LA. The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull 1987;13:261-276. https://doi.org/10.1093/schbul/13.2.261
  8. Langeveld J, Andreassen OA, Auestad B, Færden A, Hauge LJ, Joa I, et al. Is there an optimal factor structure of the Positive and Negative Syndrome Scale in patients with first-episode psychosis? Scand J Psychol 2013;54:160-165. https://doi.org/10.1111/sjop.12017
  9. Hwang SS, Chang JS, Lee KY, Ahn YM, Kim YS. The causal model of insight in schizophrenia based on the Positive and Negative Syndrome Scale factors and the structural equation modeling. J Nerv Ment Dis 2009;197:79-84. https://doi.org/10.1097/NMD.0b013e318196083e
  10. Nayani TH, David AS. The auditory hallucination: a phenomenological survey. Psychol Med 1996;26:177-189. https://doi.org/10.1017/S003329170003381X
  11. Mueser KT, Bellack AS, Brady EU. Hallucinations in schizophrenia. Acta Psychiatr Scand 1990;82:26-29. https://doi.org/10.1111/j.1600-0447.1990.tb01350.x
  12. Böcker KB, Hijman R, Kahn RS, De Haan EH. Perception, mental imagery and reality discrimination in hallucinating and non-hallucinating schizophrenic patients. Br J Clin Psychol 2000;39(Pt 4):397-406. https://doi.org/10.1348/014466500163392
  13. Harkavy-Friedman JM, Kimhy D, Nelson EA, Venarde DF, Malaspina D, Mann JJ. Suicide attempts in schizophrenia: the role of command auditory hallucinations for suicide. J Clin Psychiatry 2003;64:871-874. https://doi.org/10.4088/JCP.v64n0803
  14. Meltzer HY. Treatment of the neuroleptic-nonresponsive schizophrenic patient. Schizophr Bull 1992;18:515-542. https://doi.org/10.1093/schbul/18.3.515
  15. Tamburini A, Berrios GE. A theory of hallucinations. Hist Psychiatry 1990;1(1 Pt 1):145-146. https://doi.org/10.1177/0957154X9000100105
  16. McCarthy-Jones S, Trauer T, Mackinnon A, Sims E, Thomas N, Copolov DL. A new phenomenological survey of auditory hallucinations: evidence for subtypes and implications for theory and practice. Schizophr Bull 2014;40:231-235. https://doi.org/10.1093/schbul/sbs156
  17. Stephane M, Thuras P, Nasrallah H, Georgopoulos AP. The internal structure of the phenomenology of auditory verbal hallucinations. Schizophr Res 2003;61:185-193. https://doi.org/10.1016/S0920-9964(03)00013-6
  18. Van Lieshout RJ, Goldberg JO. Quantifying self-reports of auditory verbal hallucinations in persons with psychosis. Canadian Journal of Behavioural Sc 2007;39:73. https://doi.org/10.1037/cjbs2007006
  19. Haddock G, McCarron J, Tarrier N, Faragher EB. Scales to measure dimensions of hallucinations and delusions: the psychotic symptom rating scales (PSYRATS). Psychol Med 1999;29:879-889. https://doi.org/10.1017/S0033291799008661
  20. Kim SH, Jung HY, Hwang SS, Chang JS, Kim Y, Ahn YM, et al. The usefulness of a self-report questionnaire measuring auditory verbal hallucinations. Prog Neuropsychopharmacol Biol Psychiatry 2010;34:968-973. https://doi.org/10.1016/j.pnpbp.2010.05.005
  21. Graux J, Bidet-Caulet A, Bonnet-Brilhault F, Camus V, Bruneau N. Hallucinations and negative symptoms differentially revealed by frontal and temporal responses to speech in schizophrenia. Schizophr Res 2014;155:39-44. https://doi.org/10.1016/j.schres.2014.03.007
  22. Brébion G, David AS, Jones H, Pilowsky LS. Hallucinations, negative symptoms, and response bias in a verbal recognition task in schizophrenia. Neuropsychology 2005;19:612-617. https://doi.org/10.1037/0894-4105.19.5.612
  23. Freeman D, Garety PA. Connecting neurosis and psychosis: the direct influence of emotion on delusions and hallucinations. Behav Res Ther 2003;41:923-947. https://doi.org/10.1016/S0005-7967(02)00104-3
  24. Heilbrun AB Jr, Blum NA. Cognitive vulnerability to auditory hallucination. Impaired perception of meaning. Br J Psychiatry 1984;144:508-512. https://doi.org/10.1192/bjp.144.5.508
  25. Johnson RL, Miller MD. Auditory hallucinations and intellectual deficit. J Psychiatr Res 1965;3:37-41. https://doi.org/10.1016/0022-3956(65)90013-0
  26. Alpert M. The signs and symptoms of schizophrenia. Compr Psychiatry 1985;26:103-112. https://doi.org/10.1016/0010-440X(85)90030-6
  27. Mintz S, Alpert M. Imagery vividness, reality testing, and schizophrenic hallucinations. J Abnorm Psychol 1972;79:310-316. https://doi.org/10.1037/h0033209
  28. Barber TX, Calverley DS. An experimental study of "hypnotic" (auditory and visual) hallucinations. J Abnorm Psychol 1964;68:13-20. https://doi.org/10.1037/h0042175
  29. Young HF, Bentall RP, Slade PD, Dewey ME. The role of brief instructions and suggestibility in the elicitation of auditory and visual hallucinations in normal and psychiatric subjects. J Nerv Ment Dis 1987;175:41-48. https://doi.org/10.1097/00005053-198701000-00007
  30. Yi JS, Ahn YM, Shin HK, An SK, Joo YH, Kim SH, et al. Reliability and validity of the Korean version of the Positive and Negative Syndrome Scale. Journal of Korean Neuropsychiatric Association 2001;40:1090-1105.
  31. Emsley R, Rabinowitz J, Torreman M. The factor structure for the Positive and Negative Syndrome Scale (PANSS) in recent-onset psychosis. Schizophr Res 2003;61:47-57. https://doi.org/10.1016/S0920-9964(02)00302-X
  32. White L, Harvey PD, Opler L, Lindenmayer JP. Empirical assessment of the factorial structure of clinical symptoms in schizophrenia. A multisite, multimodel evaluation of the factorial structure of the Positive and Negative Syndrome Scale. The PANSS Study Group. Psychopathology 1997;30:263-274. https://doi.org/10.1159/000285058
  33. van der Gaag M, Cuijpers A, Hoffman T, Remijsen M, Hijman R, de Haan L, et al. The five-factor model of the Positive and Negative Syndrome Scale I: confirmatory factor analysis fails to confirm 25 published five-factor solutions. Schizophr Res 2006;85:273-279. https://doi.org/10.1016/j.schres.2006.04.001
  34. Wallwork RS, Fortgang R, Hashimoto R, Weinberger DR, Dickinson D. Searching for a consensus five-factor model of the Positive and Negative Syndrome Scale for schizophrenia. Schizophr Res 2012;137:246-250. https://doi.org/10.1016/j.schres.2012.01.031
  35. Nakaya M, Suwa H, Ohmori K. Latent structures underlying schizophrenic symptoms: a five-dimensional model. Schizophr Res 1999;39:39-50. https://doi.org/10.1016/S0920-9964(99)00018-3
  36. Jung SM, Kim MK, Lee JB, Choi JH, Jung BJ, Byun WT. Reliability and validity of the Korean version of the Psychotic Symptom Rating Scale. Journal of Korean Neuropsychiatric Association 2007;46:201-213.
  37. Andreasen NC, Olsen S. Negative v positive schizophrenia. Definition and validation. Arch Gen Psychiatry 1982;39:789-794. https://doi.org/10.1001/archpsyc.1982.04290070025006
  38. Strauss JS, Carpenter WT Jr, Bartko JJ. The diagnosis and understanding of schizophrenia. Part III. Speculations on the processes that underlie schizophrenic symptoms and signs. Schizophr Bull 1974;(11):61-69.
  39. Peralta V, Cuesta MJ, de Leon J. An empirical analysis of latent structures underlying schizophrenic symptoms: a four-syndrome model. Biol Psychiatry 1994;36:726-736. https://doi.org/10.1016/0006-3223(94)90083-3
  40. Dollfus S, Everitt B. Symptom structure in schizophrenia: two-, three- or four-factor models? Psychopathology 1998;31:120-130. https://doi.org/10.1159/000066235
  41. Cuesta MJ, Peralta V. Psychopathological dimensions in schizophrenia. Schizophr Bull 1995;21:473-482. https://doi.org/10.1093/schbul/21.3.473
  42. Lindenmayer JP, Bernstein-Hyman R, Grochowski S. Five-factor model of schizophrenia. Initial validation. J Nerv Ment Dis 1994;182:631-638. https://doi.org/10.1097/00005053-199411000-00006
  43. Lowe GR. The phenomenology of hallucinations as an aid to differential diagnosis. Br J Psychiatry 1973;123:621-633. https://doi.org/10.1192/bjp.123.6.621
  44. Peralta V, Cuesta MJ. Clinical models of schizophrenia: a critical approach to competing conceptions. Psychopathology 2000;33:252-258. https://doi.org/10.1159/000029154
  45. Bentall RP. The illusion of reality: a review and integration of psychological research on hallucinations. Psychol Bull 1990;107:82-95. https://doi.org/10.1037/0033-2909.107.1.82
  46. Morrison AP, Haddock G, Tarrier N. Intrusive thoughts and auditory hallucinations: a cognitive approach. Behav Cogn Psychother 1995;23:265-280. https://doi.org/10.1017/S1352465800015873
  47. Hoffman RE. Verbal hallucinations and language production processes in schizophrenia. Behav Brain Res 1986;9:503-548.
  48. Frith CD. The Cognitive Neuropsychology of Schizophrenia. 1st ed. Hillsdale: Lawrence Erlbaum;1992.
  49. Smith B, Fowler DG, Freeman D, Bebbington P, Bashforth H, Garety P, et al. Emotion and psychosis: links between depression, selfesteem, negative schematic beliefs and delusions and hallucinations. Schizophr Res 2006;86:181-188. https://doi.org/10.1016/j.schres.2006.06.018
  50. Andreasen NC, Arndt S, Alliger R, Miller D, Flaum M. Symptoms of schizophrenia. Methods, meanings, and mechanisms. Arch Gen Psychiatry 1995;52:341-351. https://doi.org/10.1001/archpsyc.1995.03950170015003
  51. Mellers JD, Sham P, Jones PB, Toone BK, Murray RM. A factor analytic study of symptoms in acute schizophrenia. Acta Psychiatr Scand 1996;93:92-98. https://doi.org/10.1111/j.1600-0447.1996.tb09808.x
  52. Peralta V, Cuesta MJ. Dimensional structure of psychotic symptoms: an item-level analysis of SAPS and SANS symptoms in psychotic disorders. Schizophr Res 1999;38:13-26. https://doi.org/10.1016/S0920-9964(99)00003-1
  53. Stuart GW, Pantelis C, Klimidis S, Minas IH. The three-syndrome model of schizophrenia: meta-analysis of an artefact. Schizophr Res 1999;39:233-242. https://doi.org/10.1016/S0920-9964(99)00019-5
  54. Hayashi N, Igarashi Y, Suda K, Nakagawa S. Phenomenological features of auditory hallucinations and their symptomatological relevance. Psychiatry Clin Neurosci 2004;58:651-659. https://doi.org/10.1111/j.1440-1819.2004.01316.x
  55. Drake R, Haddock G, Tarrier N, Bentall R, Lewis S. The Psychotic Symptom Rating Scales (PSYRATS): their usefulness and properties in first episode psychosis. Schizophr Res 2007;89:119-122. https://doi.org/10.1016/j.schres.2006.04.024
  56. Carter DM, Mackinnon A, Howard S, Zeegers T, Copolov DL. The development and reliability of the Mental Health Research Institute Unusual Perceptions Schedule (MUPS): an instrument to record auditory hallucinatory experience. Schizophr Res 1995;16:157-165. https://doi.org/10.1016/0920-9964(94)00069-K
  57. Chadwick P, Birchwood M. The omnipotence of voices. II: The Beliefs About Voices Questionnaire (BAVQ). Br J Psychiatry 1995;166:773-776. https://doi.org/10.1192/bjp.166.6.773
  58. Chung IW, Hwang SSH, Kim SH, Chang JS, Jung HY, Kim YS. Long-term improvement in auditory verbal hallucinations: Clinician vs. patient perspectives. Poster presentation at the 12th World Congress of Biological Psychiatry;2015 Jun 14-18, Athens, Greece.
  59. Chang JS, Yi JS, Ahn YM, Kim JH, Kim YS. Stabilization of the internal structure of persistent auditory verbal hallucinations in schizophrenia. Aust N Z J Psychiatry 2009;43:244-251. https://doi.org/10.1080/00048670802653299