Asian Pacific Journal of Cancer Prevention

  • 제15권24호
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  • Pages.10985-10989
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  • 2015
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  • 1513-7368(pISSN)
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  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
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DNA Ligase4 as a Prognostic Marker in Nasopharyngeal Cancer Patients Treated with Radiotherapy

  • Kim, Dong Hyun (Department of Internal Medicine, Dong-A University College of Medicine) ;
  • Oh, Sung Yong (Department of Internal Medicine, Dong-A University College of Medicine) ;
  • Kim, So Yeon (Department of Internal Medicine, Dong-A University College of Medicine) ;
  • Lee, Seul (Department of Internal Medicine, Dong-A University College of Medicine) ;
  • Koh, Myeong Seok (Department of Internal Medicine, Dong-A University College of Medicine) ;
  • Lee, Ji Hyun (Department of Internal Medicine, Dong-A University College of Medicine) ;
  • Lee, Suee (Department of Internal Medicine, Dong-A University College of Medicine) ;
  • Kim, Sung-Hyun (Department of Internal Medicine, Dong-A University College of Medicine) ;
  • Park, Heon Soo (Department of Otolaryngology-Head and Neck Surgery, Dong-A University College of Medicine) ;
  • Hur, Won Joo (Department of Radiation Oncology, Dong-A University College of Medicine) ;
  • Jeong, Jin Sook (Department of Pathology, Dong-A University College of Medicine) ;
  • Ju, Mi Ha (Department of Pathology, Dong-A University College of Medicine) ;
  • Seol, Young Mi (Internal Medicine, Pusan National University Hospital, College of Medicine) ;
  • Choi, Young-Jin (Internal Medicine, Pusan National University Hospital, College of Medicine) ;
  • Chung, Joo Seop (Internal Medicine, Pusan National University Hospital, College of Medicine) ;
  • Kim, Hyo-Jin (Department of Internal Medicine, Dong-A University College of Medicine)
  • 발행 : 2015.01.22
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초록

Background: The capability for DNA double-strand breaks (DSBs) repair is crucial for inherent radiosensitivity of tumor and normal cells. We have investigated the clinicopathologic significance of DNA repair gene expression in nasopharyngeal (NP) carcinoma. Materials and Methods: A total of 65 NP cancer patients who received radiotherapy were included. The immunopositivity to Ku 70, DNA-PKcs, MRN, RAD50, XRCC4, and LIG4 were examined in all tumor tissues. Results: The patients comprised 42 males and 23 females, with a median age of 56 years (range, 18-84). The expression levels of RAD50 (0,+1,+2,+3) were 27.7%, 32.3%, 21.5%, and 18.5%. LIG4 (${\pm}$) were 43.1% and 56.9% respectively. The 5-year OS rate of patients with LIG4 (${\pm}$) were 90% and 67.9%, respectively (p=0.035). The 5-year TTP rate of patients with LIG4 (${\pm}$) were 75.9%, 55.5%, respectively (P=0.039). Conclusions: Our results suggest the possibility of predicting the radiosensitivity of NP cancer by performing immunohistochemical analysis of LIG4.

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참고문헌

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