Annals of Laboratory Medicine

Korean Society for Laboratory Medicine (대한진단검사의학회)
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Loss of Mismatched HLA Detected in the Peripheral Blood of an AML Patient who Relapsed After Haploidentical Hematopoietic Stem Cell Transplantation

  • Park, Borae G. (Department of Laboratory Medicine, University of Ulsan College of Medicine and Asan Medical Center) ;
  • Sohn, Yong-Hak (Department of Laboratory Medicine, Eulji University Hospital) ;
  • Oh, Heung-Bum (Department of Laboratory Medicine, University of Ulsan College of Medicine and Asan Medical Center) ;
  • Seo, Eul-Ju (Department of Laboratory Medicine, University of Ulsan College of Medicine and Asan Medical Center) ;
  • Jang, Seongsoo (Department of Laboratory Medicine, University of Ulsan College of Medicine and Asan Medical Center) ;
  • Hong, Sun Pyo (R&D Center, GeneMatrix Inc.)
  • Received : 2014.10.30
  • Accepted : 2015.06.01
  • Published : 2015.09.01
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Abstract

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References

  1. Vago L, Perna SK, Zanussi M, Mazzi B, Barlassina C, Stanghellini MT, et al. Loss of mismatched HLA in leukemia after stem-cell transplantation. N Engl J Med 2009;361:478-88. https://doi.org/10.1056/NEJMoa0811036
  2. Villalobos IB, Takahashi Y, Akatsuka Y, Muramatsu H, Nishio N, Hama A, et al. Relapse of leukemia with loss of mismatched HLA resulting from uniparental disomy after haploidentical hematopoietic stem cell transplantation. Blood 2010;115:3158-61. https://doi.org/10.1182/blood-2009-11-254284
  3. Tamaki H, Fujioka T, Ikegame K, Yoshihara S, Kaida K, Taniguchi K, et al. Different mechanisms causing loss of mismatched human leukocyte antigens in relapsing t(6;11)(q27;q23) acute myeloid leukemia after haploidentical transplantation. Eur J Haematol 2012;89:497-500. https://doi.org/10.1111/ejh.12017
  4. Kobayashi S, Kikuta A, Ito M, Sano H, Mochizuki K, Akaihata M, et al. Loss of mismatched HLA in myeloid/NK cell precursor acute leukemia relapse after T cell-replete haploidentical hematopoietic stem cell transplantation. Pediatr Blood Cancer 2014;61:1880-2. https://doi.org/10.1002/pbc.24962
  5. Barrios M, Jimenez-Velasco A, Roman-Gomez J, Madrigal ME, Castillejo JA, Torres A, et al. Chimerism status is a useful predictor of relapse after allogeneic stem cell transplantation for acute leukemia. Haematologica 2003;88:801-10.
  6. Raghavan M, Smith LL, Lillington DM, Chaplin T, Kakkas I, Molloy G, et al. Segmental uniparental disomy is a commonly acquired genetic event in relapsed acute myeloid leukemia. Blood 2008;112:814-21. https://doi.org/10.1182/blood-2008-01-132431
  7. Barresi V, Romano A, Musso N, Capizzi C, Consoli C, Martelli MP, et al. Broad copy neutral-loss of heterozygosity regions and rare recurring copy number abnormalities in normal karyotype-acute myeloid leukemia genomes. Genes Chromosomes Cancer 2010;49:1014-23. https://doi.org/10.1002/gcc.20810

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  1. Epidemiology and biology of relapse after stem cell transplantation vol.53, pp.11, 2018, https://doi.org/10.1038/s41409-018-0171-z
  2. Prevention of relapse after allogeneic stem cell transplantation in acute myeloid leukemia: Updates and challenges vol.3, pp.2, 2015, https://doi.org/10.1002/acg2.77