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The e1a3 BCR-ABL1 Fusion Transcript in Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia

  • Langabeer, Stephen E. (Cancer Molecular Diagnostics, St. James' Hospital)
  • Received : 2015.01.19
  • Accepted : 2015.06.01
  • Published : 2015.09.01

Abstract

Keywords

References

  1. Shin SY, Cho JH, Kim HJ, Jang JH, Lee ST, Kim SH. Two cases of acute lymphoblastic leukemia with an e1a3 BCR-ABL1 fusion transcript. Ann Lab Med 2015;35:159-61. https://doi.org/10.3343/alm.2015.35.1.159
  2. Langabeer SE, Haslam K, Kelly J, Leahy M, Vandenberghe E. Acute lymphoblastic leukaemia with an e1a3 BCR-ABL1 fusion. Acta Haematol 2011;126:214-5. https://doi.org/10.1159/000330956
  3. Chen Y, Wang HW, Chen XH, Xu ZF, Qin YH, Ren FG, et al. Adult acute lymphoblastic leukemia with atypical BCR-ABL transcript e1a3: a case report and literature review. Zhonghua Xue Ye Xue Za Zhi 2013;34:965-6.
  4. McCarron SL, Haslam K, Kelly J, Duggan C, Langabeer SE. A novel, variant BCR-ABL1 transcript not detected by standard real-time quantitative PCR in a patient with chronic myeloid leukaemia. Int J Lab Hematol 2012;34:e1-2.
  5. Park TS, Kim JS, Song J, Lee KA, Yoon S, Suh B, et al. Acute promyelocytic leukemia with insertion of PML exon 7a and partial deletion of exon 3 of RARA: a novel variant transcript related to aggressive course and not detected with real-time polymerase chain reaction analysis. Cancer Genet Cytogenet 2009;188:103-7. https://doi.org/10.1016/j.cancergencyto.2008.09.002
  6. Ravandi F, Jorgensen JL, Thomas DA, O'Brien S, Garris R, Faderl S, et al. Detection of MRD may predict the outcome of patients with Philadelphia chromosome-positive ALL treated with tyrosine kinase inhibitors plus chemotherapy. Blood 2013;122:1214-21. https://doi.org/10.1182/blood-2012-11-466482

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