Annals of Laboratory Medicine

Korean Society for Laboratory Medicine (대한진단검사의학회)
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Therapeutic Plasma Exchange Using the Spectra Optia Cell Separator Compared With the COBE Spectra

  • Kim, Do-kyun (Department of Laboratory Medicine, Yonsei University College of Medicine) ;
  • Kim, Sinyoung (Department of Laboratory Medicine, Yonsei University College of Medicine) ;
  • Jeong, Seok Hoon (Department of Laboratory Medicine, Yonsei University College of Medicine) ;
  • Kim, Hyun Ok (Department of Laboratory Medicine, Yonsei University College of Medicine) ;
  • Kim, Hyung Jik (Department of Internal Medicine and Kidney Research Institute, Hallym University Sacred Heart Hospital, Hallym University College of Medicine)
  • Received : 2014.10.22
  • Accepted : 2015.05.21
  • Published : 2015.09.01
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Abstract

Background: The Spectra Optia (SPO) is a novel continuous-flow centrifugal apheresis system based on the COBE Spectra (CSP) platform. There have been few attempts to validate the advantages of the SPO. We performed a retrospective study comparing the two cell separators for therapeutic plasma exchange (TPE) procedures in kidney transplant (KT) patients and seeing efficacy and safety. Methods: We analyzed 720 TPE procedures performed between August 2012 and July 2014. Procedures included desensitization TPE before KT and TPE for the management of acute and chronic antibody-mediated graft rejection. Demographic characteristics, operational TPE variables, and laboratory data were analyzed. Results: Demographic characteristics for the SPO (n=389) and CSP (n=331) groups did not differ significantly. The procedure time to exchange one plasma volume was $94.2{\pm}10.3min$ in the SPO group and $100.4{\pm}11.2min$ in the CSP group (P<0.001). The plasma removal efficiency (PRE) was $92.5{\pm}4.9%$ in the SPO group and $83.2{\pm}3.7%$ in the CSP group (P<0.001). There were no significant differences across the two apheresis systems for changes in hematologic parameters. Conclusions: Compared with the CSP, the SPO was associated with an improved PRE and a shorter procedure time to exchange one plasma volume. Our results in KT patients show that the SPO is superior to the CSP in TPE procedures.

Keywords

References

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