Korean Journal of Radiology

The Korean Society of Radiology (대한영상의학회)
권호 표지
DOI QR코드

DOI QR Code

Immunoglobulin G4-Related Kidney Disease: A Comprehensive Pictorial Review of the Imaging Spectrum, Mimickers, and Clinicopathological Characteristics

  • Seo, Nieun (Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Kim, Jin Hee (Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Byun, Jae Ho (Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Lee, Seung Soo (Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Kim, Hyoung Jung (Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Lee, Moon-Gyu (Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine)
  • Received : 2015.04.01
  • Accepted : 2015.05.20
  • Published : 2015.09.01
⟨ Previous Next ⟩

Abstract

Immunoglobulin G4 (IgG4)-related kidney disease (IgG4-KD) has recently been demonstrated to be an important part of IgG4-related sclerosing disease (IgG4-SD). However, since IgG4-KD is still relatively unfamiliar to radiologists and physicians as compared to IgG4-SD involving other organs, it could, therefore, be easily missed. In this article, we present a comprehensive pictorial review of IgG4-KD with regards to the imaging spectrum, mimickers, and clinicopathologic characteristics, based on our clinical experience with 48 patients during the past 13 years, as well as a literature review. Awareness of the broad imaging spectrum of IgG4-KD and differential diagnosis from its mimickers will thus facilitate its early diagnosis and treatment.

Keywords

References

  1. Cornell LD. IgG4-related kidney disease. Semin Diagn Pathol 2012;29:245-250 https://doi.org/10.1053/j.semdp.2012.07.004
  2. Stone JH, Zen Y, Deshpande V. IgG4-related disease. N Engl J Med 2012;366:539-551 https://doi.org/10.1056/NEJMra1104650
  3. Deshpande V, Zen Y, Chan JK, Yi EE, Sato Y, Yoshino T, et al. Consensus statement on the pathology of IgG4-related disease. Mod Pathol 2012;25:1181-1192 https://doi.org/10.1038/modpathol.2012.72
  4. Umehara H, Okazaki K, Masaki Y, Kawano M, Yamamoto M, Saeki T, et al. Comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD), 2011. Mod Rheumatol 2012;22:21-30 https://doi.org/10.3109/s10165-011-0571-z
  5. Raissian Y, Nasr SH, Larsen CP, Colvin RB, Smyrk TC, Takahashi N, et al. Diagnosis of IgG4-related tubulointerstitial nephritis. J Am Soc Nephrol 2011;22:1343-1352 https://doi.org/10.1681/ASN.2011010062
  6. Saeki T, Kawano M, Mizushima I, Yamamoto M, Wada Y, Nakashima H, et al. The clinical course of patients with IgG4-related kidney disease. Kidney Int 2013;84:826-833 https://doi.org/10.1038/ki.2013.191
  7. Kawano M, Saeki T, Nakashima H, Nishi S, Yamaguchi Y, Hisano S, et al. Proposal for diagnostic criteria for IgG4-related kidney disease. Clin Exp Nephrol 2011;15:615-626 https://doi.org/10.1007/s10157-011-0521-2
  8. Khalili K, Doyle DJ, Chawla TP, Hanbidge AE. Renal cortical lesions in patients with autoimmune pancreatitis: a clue to differentiation from pancreatic malignancy. Eur J Radiol 2008;67:329-335 https://doi.org/10.1016/j.ejrad.2007.07.020
  9. Kim B, Kim JH, Byun JH, Kim HJ, Lee SS, Kim SY, et al. IgG4-related kidney disease: MRI findings with emphasis on the usefulness of diffusion-weighted imaging. Eur J Radiol 2014;83:1057-1062 https://doi.org/10.1016/j.ejrad.2014.03.033
  10. Saeki T, Nishi S, Imai N, Ito T, Yamazaki H, Kawano M, et al. Clinicopathological characteristics of patients with IgG4-related tubulointerstitial nephritis. Kidney Int 2010;78:1016-1023 https://doi.org/10.1038/ki.2010.271
  11. Khosroshahi A, Stone JH. A clinical overview of IgG4-related systemic disease. Curr Opin Rheumatol 2011;23:57-66 https://doi.org/10.1097/BOR.0b013e3283418057
  12. Takahashi N, Kawashima A, Fletcher JG, Chari ST. Renal involvement in patients with autoimmune pancreatitis: CT and MR imaging findings. Radiology 2007;242:791-801 https://doi.org/10.1148/radiol.2423060003
  13. Kim JH, Kim MH, Byun JH, Lee SS, Lee SJ, Park SH, et al. Diagnostic strategy for differentiating autoimmune pancreatitis from pancreatic cancer: is an endoscopic retrograde pancreatography essential? Pancreas 2012;41:639-647 https://doi.org/10.1097/MPA.0b013e31823a509b
  14. Kuroda N, Nakamura S, Miyazaki K, Inoue K, Ohara M, Mizuno K, et al. Chronic sclerosing pyelitis with an increased number of IgG4-positive plasma cells. Med Mol Morphol 2009;42:236-238 https://doi.org/10.1007/s00795-008-0425-8
  15. Kim SA, Lee SR, Huh J, Shen SS, Ro JY. IgG4-associated inflammatory pseudotumor of ureter: clinicopathologic and immunohistochemical study of 3 cases. Hum Pathol 2011;42:1178-1184 https://doi.org/10.1016/j.humpath.2010.03.011
  16. Sharma SG, Vlase HL, D’Agati VD. IgG4-related tubulointerstitial nephritis with plasma cell-rich renal arteritis. Am J Kidney Dis 2013;61:638-643 https://doi.org/10.1053/j.ajkd.2012.07.031
  17. Saeki T, Kawano M. IgG4-related kidney disease. Kidney Int 2014;85:251-257 https://doi.org/10.1038/ki.2013.393
  18. Yamaguchi Y, Kanetsuna Y, Honda K, Yamanaka N, Kawano M, Nagata M; Japanese study group on IgG4-related nephropathy. Characteristic tubulointerstitial nephritis in IgG4-related disease. Hum Pathol 2012;43:536-549 https://doi.org/10.1016/j.humpath.2011.06.002
  19. Triantopoulou C, Malachias G, Maniatis P, Anastopoulos J, Siafas I, Papailiou J. Renal lesions associated with autoimmune pancreatitis: CT findings. Acta Radiol 2010;51:702-707 https://doi.org/10.3109/02841851003738846
  20. Hedgire SS, McDermott S, Borczuk D, Elmi A, Saini S, Harisinghani MG. The spectrum of IgG4-related disease in the abdomen and pelvis. AJR Am J Roentgenol 2013;201:14-22 https://doi.org/10.2214/AJR.12.9995
  21. Vlachou PA, Khalili K, Jang HJ, Fischer S, Hirschfield GM, Kim TK. IgG4-related sclerosing disease: autoimmune pancreatitis and extrapancreatic manifestations. Radiographics 2011;31:1379-1402 https://doi.org/10.1148/rg.315105735
  22. Manfredi R, Frulloni L, Mantovani W, Bonatti M, Graziani R, Pozzi Mucelli R. Autoimmune pancreatitis: pancreatic and extrapancreatic MR imaging-MR cholangiopancreatography findings at diagnosis, after steroid therapy, and at recurrence. Radiology 2011;260:428-436 https://doi.org/10.1148/radiol.11101729
  23. Pozdzik AA, Matos C, Rorive S, Brocheriou I, Delhaye M, Nortier JL. Diffusion-weighted magnetic resonance imaging: a non-nephrotoxic prompt assessment of kidney involvement in IgG4-related disease. Kidney Int 2014;85:981
  24. Sasiwimonphan K, Gorman B, Kawashima A, Chari ST, Takahashi N. Renal involvement in patients with autoimmune pancreatitis: ultrasound findings. Eur J Radiol 2012;81:807-810 https://doi.org/10.1016/j.ejrad.2011.02.002
  25. Saunders HS, Dyer RB, Shifrin RY, Scharling ES, Bechtold RE, Zagoria RJ. The CT nephrogram: implications for evaluation of urinary tract disease. Radiographics 1995;15:1069-1085; discussion 1086-1088 https://doi.org/10.1148/radiographics.15.5.7501851
  26. Kawashima A, Sandler CM, Goldman SM, Raval BK, Fishman EK. CT of renal inflammatory disease. Radiographics 1997;17:851-866; discussion 867-868 https://doi.org/10.1148/radiographics.17.4.9225387
  27. Suzer O, Shirkhoda A, Jafri SZ, Madrazo BL, Bis KG, Mastromatteo JF. CT features of renal infarction. Eur J Radiol 2002;44:59-64 https://doi.org/10.1016/S0720-048X(01)00476-4
  28. Wong WS, Moss AA, Federle MP, Cochran ST, London SS. Renal infarction: CT diagnosis and correlation between CT findings and etiologies. Radiology 1984;150:201-205 https://doi.org/10.1148/radiology.150.1.6689761
  29. Honda H, Coffman CE, Berbaum KS, Barloon TJ, Masuda K. CT analysis of metastatic neoplasms of the kidney. Comparison with primary renal cell carcinoma. Acta Radiol 1992;33:39-44 https://doi.org/10.1177/028418519203300108
  30. Bracken RB, Chica G, Johnson DE, Luna M. Secondary renal neoplasms: an autopsy study. South Med J 1979;72:806-807 https://doi.org/10.1097/00007611-197907000-00013
  31. Ganeshan D, Iyer R, Devine C, Bhosale P, Paulson E. Imaging of primary and secondary renal lymphoma. AJR Am J Roentgenol 2013;201:W712-W719 https://doi.org/10.2214/AJR.13.10669
  32. Jafri SZ, Bree RL, Amendola MA, Glazer GM, Schwab RE, Francis IR, et al. CT of renal and perirenal non-Hodgkin lymphoma. AJR Am J Roentgenol 1982;138:1101-1105 https://doi.org/10.2214/ajr.138.6.1101
  33. Semelka RC, Kelekis NL, Burdeny DA, Mitchell DG, Brown JJ, Siegelman ES. Renal lymphoma: demonstration by MR imaging. AJR Am J Roentgenol 1996;166:823-827 https://doi.org/10.2214/ajr.166.4.8610558
  34. Saremi F, Knoll AN, Bendavid OJ, Schultze-Haakh H, Narula N, Sarlati F. Characterization of genitourinary lesions with diffusion-weighted imaging. Radiographics 2009;29:1295-1317 https://doi.org/10.1148/rg.295095003
  35. Yamashita Y, Takahashi M, Watanabe O, Yoshimatsu S, Ueno S, Ishimaru S, et al. Small renal cell carcinoma: pathologic and radiologic correlation. Radiology 1992;184:493-498 https://doi.org/10.1148/radiology.184.2.1620854

Cited by

  1. IgG4-related disease: what urologists should know vol.48, pp.3, 2015, https://doi.org/10.1007/s11255-015-1189-4
  2. Idiopathic Retroperitoneal Fibrosis Involving a Unilateral Renal Sinus: A Case Report and Literature Review vol.74, pp.6, 2016, https://doi.org/10.3348/jksr.2016.74.6.412
  3. IgG4-Related Kidney Disease: Report of a Case Presenting as a Renal Mass vol.2017, pp.None, 2015, https://doi.org/10.1155/2017/9690218
  4. IgG4-related disease: a complex under-diagnosed clinical entity vol.38, pp.2, 2015, https://doi.org/10.1007/s00296-017-3765-7
  5. Imaging findings of IgG4-related kidney disease without extrarenal organ involvement : A case report vol.98, pp.34, 2015, https://doi.org/10.1097/md.0000000000016934
  6. A case of IgG4-related tubulointerstitial nephritis and membranous glomerulonephritis during the clinical course of gastric cancer: Imaging features of IgG4-related kidney disease vol.29, pp.3, 2015, https://doi.org/10.1080/14397595.2016.1245238
  7. CT Findings of Upper Urinary Tract Lesions in IgG4-Related Disease: Comparison With Urothelial Carcinoma vol.215, pp.2, 2015, https://doi.org/10.2214/ajr.19.22192
  8. Immunoglobulin G4-related Disease of the Genitourinary System: Spectrum of Imaging Findings and Clinical-Pathologic Features vol.40, pp.5, 2015, https://doi.org/10.1148/rg.2020200043
  9. Rapidly Progressive Kidney Failure Associated with Perirenal Capsular Lesion Due to IgG4-Related Disease vol.60, pp.12, 2015, https://doi.org/10.2169/internalmedicine.6232-20
  10. Infiltrative Renal Malignancies: Imaging Features, Prognostic Implications, and Mimics vol.41, pp.2, 2015, https://doi.org/10.1148/rg.2021200123