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A Rare Cause of Secondary Hypertension in A Young Adult

  • Choi, Jae-Hyuk (Division of Cardiology, Department of Internal Medicine, Dong-A University College of Medicine) ;
  • Park, Tae-Ho (Division of Cardiology, Department of Internal Medicine, Dong-A University College of Medicine) ;
  • Kim, Moo-Hyun (Division of Cardiology, Department of Internal Medicine, Dong-A University College of Medicine) ;
  • Kim, Young-Dae (Division of Cardiology, Department of Internal Medicine, Dong-A University College of Medicine) ;
  • Rhyou, Hyo In (Department of Internal Medicine, Dong-A University College of Medicine) ;
  • Rha, Seo Hee (Department of Pathology, Dong-A University College of Medicine) ;
  • Park, Kwon Jae (Department of Cardiovascular Surgery, Dong-A University College of Medicine) ;
  • Woo, Jong Soo (Department of Cardiovascular Surgery, Dong-A University College of Medicine)
  • Received : 2014.01.26
  • Accepted : 2015.03.25
  • Published : 2015.11.30

Abstract

Reninoma is a rare, renin-secreting, benign renal neoplasm that can cause secondary hypertension. We report a case of a 21-year-old man who suffered from progressively worsening headache for 2 months with a history of hypertension for 7 years. Laboratory studies showed normal potassium level, increased basal plasma renin activity, and normal serum aldosterone level. Abdominal computed tomography and magnetic resonance imaging revealed a small mass in the middle region of the right kidney. Partial nephrectomy was performed; immunohistochemical results demonstrated typical features of reninoma. Postoperatively, blood pressure and potassium level were normal at the 2-month follow-up.

Keywords

References

  1. Eddy RL, Sanchez SA. Renin-secreting renal neoplasm and hypertension with hypokalemia. Ann Intern Med 1971;75:725-9. https://doi.org/10.7326/0003-4819-75-5-725
  2. Robertson PW, Klidjian A, Harding LK, Walters G, Lee MR, Robb-Smith AH. Hypertension due to a renin-secreting renal tumour. Am J Med 1967;43:963-76. https://doi.org/10.1016/0002-9343(67)90256-2
  3. Lin SY, Liu WY, Chen WC, Chen RH. Secondary hypertension due to a renin-secreting juxtaglomerular cell tumor. J Formos Med Assoc 2010;109:237-40. https://doi.org/10.1016/S0929-6646(10)60047-2
  4. Wong L, Hsu TH, Perlroth MG, Hofmann LV, Haynes CM, Katznelson L. Reninoma: case report and literature review. J Hypertens 2008;26:368-73. https://doi.org/10.1097/HJH.0b013e3282f283f3
  5. Conn JW, Cohen EL, Lucas CP, et al. Primary reninism. Hypertension, hyperreninemia, and secondary aldosteronism due to renin-producing juxtaglomerular cell tumors. Arch Intern Med 1972;130:682-96. https://doi.org/10.1001/archinte.1972.03650050016004
  6. Dong D, Li H, Yan W, Xu W. Juxtaglomerular cell tumor of the kidney--a new classification scheme. Urol Oncol 2010;28:34-8. https://doi.org/10.1016/j.urolonc.2009.08.003
  7. Dong D, Li H, Yan W, Xu W, Lu L, Zeng Z. The diagnosis and surgical management of juxtaglomerular cell tumor of the kidney. J Hypertens 2010;28:628-32. https://doi.org/10.1097/HJH.0b013e328333b056
  8. Lindop GB, Stewart JA, Downie TT. The immunocytochemical demonstration of renin in a juxtaglomerular cell tumour by light and electron microscopy. Histopathology 1983;7:421-31. https://doi.org/10.1111/j.1365-2559.1983.tb02255.x
  9. Kim HJ, Kim CH, Choi YJ, Ayala AG, Amirikachi M, Ro JY. Juxtaglomerular cell tumor of kidney with CD34 and CD117 immunoreactivity: report of 5 cases. Arch Pathol Lab Med 2006;130:707-11.
  10. Mete UK, Niranjan J, Kusum J, Rajesh LS, Goswami AK, Sharma SK. Reninoma treated with nephron-sparing surgery. Urology 2003;61:1259.
  11. Haab F, Duclos JM, Guyenne T, Plouin PF, Corvol P. Renin secretng tumors: diagnosis, conservative surgical approach and long-term results. J Urol 1995;153:1781-4. https://doi.org/10.1016/S0022-5347(01)67304-X