Korean Circulation Journal

The Korean Society of Cardiology (대한심장학회)
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A Novel Echocardiographic Method for Assessing Arterial Stiffness in Obstructive Sleep Apnea Syndrome

  • Akdag, Serkan (Department of Cardiology, Yuzuncu Yil University Medical Faculty) ;
  • Akyol, Aytac (Department of Cardiology, Yuzuncu Yil University Medical Faculty) ;
  • Cakmak, Huseyin Altug (Department of Cardiology, Rize Kackar Government Hospital) ;
  • Gunbatar, Hulya (Department of Pulmonary Diseas, Yuzuncu Yil University Medical Faculty) ;
  • Asker, Muntecep (Department of Cardiology, Yuzuncu Yil University Medical Faculty) ;
  • Babat, Naci (Department of Cardiology, Yuzuncu Yil University Medical Faculty) ;
  • Tosu, Aydin Rodi (Department of Cardiology, Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Education and Training Hospital) ;
  • Yaman, Mehmet (Department of Cardiology, Samsun Education and Training Hospital) ;
  • Gumrukcuoglu, Hasan Ali (Department of Cardiology, Yuzuncu Yil University Medical Faculty)
  • Received : 2015.02.20
  • Accepted : 2015.06.02
  • Published : 2015.11.30
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Abstract

Background and Objectives: Obstructive sleep apnea syndrome (OSAS) is associated with increased arterial stiffness and cardiovascular complications. The objective of this study was to assess whether the color M-mode-derived propagation velocity of the descending thoracic aorta (aortic velocity propagation, AVP) was an echocardiographic marker for arterial stiffness in OSAS. Subjects and Methods: The study population included 116 patients with OSAS and 90 age and gender-matched control subjects. The patients with OSAS were categorized according to their apnea hypopnea index (AHI) as follows: mild to moderate degree (AHI 5-30) and severe degree ($AHI{\geq}30$). Aortofemoral pulse wave velocity (PWV), carotid intima-media thickness (CIMT), brachial artery flow-mediated dilatation (FMD), and AVP were measured to assess arterial stiffness. Results: AVP and FMD were significantly decreased in patients with OSAS compared to controls (p<0.001). PWV and CIMT were increased in the OSAS group compared to controls (p<0.001). Moreover, AVP and FMD were significantly decreased in the severe OSAS group compared to the mild to moderate OSAS group (p<0.001). PWV and CIMT were significantly increased in the severe group compared to the mild to moderate group (p<0.001). AVP was significantly positively correlated with FMD (r=0.564, p<0.001). However, it was found to be significantly inversely related to PWV (r=-0.580, p<0.001) and CIMT (r=-0.251, p<0.001). Conclusion: The measurement of AVP is a novel and practical echocardiographic method, which may be used to identify arterial stiffness in OSAS.

Keywords

References

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