Asian Pacific Journal of Cancer Prevention

  • 제15권23호
  • /
  • Pages.10067-10070
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  • 2015
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  • 1513-7368(pISSN)
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  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
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Antiproliferative Effect of Metformin on the Endometrium - a Clinical Trial

  • Tabrizi, Ali Dastranj (Women's Reproductive Health Research Center, Medicine, Tabriz University of Medical Sciences) ;
  • Melli, Manijeh Sayyah (Women's Reproductive Health Research Center, Medicine, Tabriz University of Medical Sciences) ;
  • Foroughi, Meraj (Women's Reproductive Health Research Center, Medicine, Tabriz University of Medical Sciences) ;
  • Ghojazadeh, Morteza (Women's Reproductive Health Research Center, Medicine, Tabriz University of Medical Sciences) ;
  • Bidadi, Sanam (Women's Reproductive Health Research Center, Medicine, Tabriz University of Medical Sciences)
  • 발행 : 2015.01.06
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초록

Background: Unopposed estrogen has a central role in development of endometrial benign, premalignant and malignant lesions. The aim of this study was to evaluate the anti-estrogenic effect of metformin on endometrial histology in comparison with progesterone. Materials and Methods: A total of 43 patients who were referred to our center for abnormal uterine bleeding and had a histologic diagnosis were disordered proliferative endometrium or simple endometrial hyperplasia were included and randomly distributed in two groups treated with metformin (500mg Bid) or megestrol (40mg daily), respectively, for three months. After this period the patients were evaluated by another endometrial biopsy to assess the impact of the two drugs in restoring normal endometrial histology. Results: Our findings revealed that metformin could induce endometrial atrophy in 21 out of 22 patients (95.5%) while this positive response was achieved in only 13 out of 21 patients (61.9%) in the megstrol group. In addition two low grade endometrial carcinomas in the metformin group responded very well. Conclusions: We conclude that metformin could be used as an effective antiestrogenic agent in control of abnormal endometrial proliferative disorders.

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참고문헌

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피인용 문헌

  1. The Impact of Diabetes on Gynecologic Cancer: Current Status and Future Directions vol.4, pp.4, 2015, https://doi.org/10.1007/s13669-015-0127-x
  2. The expanding role of metformin in cancer: an update on antitumor mechanisms and clinical development vol.11, pp.4, 2016, https://doi.org/10.1007/s11523-016-0423-z
  3. A comparison between the effects of metformin and megestrol on simple endometrial hyperplasia vol.33, pp.2, 2017, https://doi.org/10.1080/09513590.2016.1223285
  4. Progestin Intrauterine Devices and Metformin: Endometrial Hyperplasia and Early Stage Endometrial Cancer Medical Management vol.5, pp.3, 2017, https://doi.org/10.3390/healthcare5030030
  5. Panobinostat Enhances Growth Suppressive Effects of Progestin on Endometrial Carcinoma by Increasing Progesterone Receptor and Mitogen-Inducible Gene-6 vol.8, pp.4, 2017, https://doi.org/10.1007/s12672-017-0295-4
  6. Induction of apoptosis by metformin and progesterone in estrogen-induced endometrial hyperplasia in rats: involvement of the bcl-2 family proteins pp.1473-0766, 2017, https://doi.org/10.1080/09513590.2017.1409708
  7. Proliferation and metastatic potential of endometrial cancer cells in response to metformin treatment in a high versus normal glucose environment vol.12, pp.5, 2016, https://doi.org/10.3892/ol.2016.5041
  8. Metformin as a Therapeutic Target in Endometrial Cancers vol.8, pp.2234-943X, 2018, https://doi.org/10.3389/fonc.2018.00341