Clinical and Experimental Pediatrics

대한소아청소년과학회 (The Korean Pediatric Society)
권호 표지
DOI QR코드

DOI QR Code

Sensorineural hearing loss in patients with Kawasaki disease

  • Park, Sun Young (Department of Pediatrics, Yeungnam University College of Medicine) ;
  • Kim, Young Hyun (Department of Pediatrics, Yeungnam University College of Medicine) ;
  • Kim, Yeo Hyang (Department of Pediatrics, Kyungpook National University School of Medicine) ;
  • Hyun, Myung Chul (Department of Pediatrics, Kyungpook National University School of Medicine) ;
  • Lee, Young Hwan (Department of Pediatrics, Yeungnam University College of Medicine)
  • 투고 : 2014.09.11
  • 심사 : 2014.11.07
  • 발행 : 2015.11.15
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Purpose: Kawasaki disease involves acute febrile systemic vasculitis that can cause a variety of symptoms by affecting various organs. Here, we aimed to evaluate the prevalence, causes, and prognosis of sensorineural hearing loss (SNHL) occurring in children with Kawasaki disease. Methods: Patients who were diagnosed with Kawasaki disease and received inpatient treatment in the Pediatrics Department at one of three university hospitals in Daegu city from February 2012 to September 2012 were enrolled in the study. The clinical features, hematological results, echocardiography results, audiometry results, and aspirin and salicylic acid serum levels of the patients were evaluated. Results: Of the 59 children enrolled in the study, three showed mild bilateral SNHL on audiometry tests conducted after 48 hours of defervescence; these patients demonstrated normal patterns of recovery on follow-up tests 8 weeks later. Aspirin serum levels were significantly higher in the SNHL group after 48 hours of afebrile condition with high dose aspirin intake (P=0.034). However, no significant differences were found in other laboratory tests or for fever duration (P>0.05). Upon echocardiography, coronary artery abnormality was observed in 9 cases, but none of these patients showed hearing loss. Conclusion: The results indicate that SNHL in children with Kawasaki disease might occur during treatment of the acute phase; this SNHL usually involves mild bilateral hearing loss and recovers naturally. However, this study suggests that determination of the causes and clinical implications of hearing loss in Kawasaki disease requires long-term follow-up studies with more cases.

키워드

참고문헌

  1. Kawasaki T. Acute febrile mucocutaneous syndrome with lymphoid involvement with specific desquamation of the fingers and toes in children. Arerugi 1967;16:178-222.
  2. Newburger JW, Takahashi M, Gerber MA, Gewitz MH, Tani LY, Burns JC, et al. Diagnosis, treatment, and long-term management of Kawasaki disease: a statement for health professionals from the Committee on Rheumatic Fever, Endocarditis and Kawasaki Disease, Council on Cardiovascular Disease in the Young, American Heart Association. Circulation 2004;110:2747-71. https://doi.org/10.1161/01.CIR.0000145143.19711.78
  3. Matsubara T, Mason W, Kashani IA, Kligerman M, Burns JC. Gastrointestinal hemorrhage complicating aspirin therapy in acute Kawasaki disease. J Pediatr 1996;128(5 Pt 1):701-3. https://doi.org/10.1016/S0022-3476(96)80140-5
  4. Knott PD, Orloff LA, Harris JP, Novak RE, Burns JC; Kawasaki Disease Multicenter Hearing Loss Study Group. Sensorineural hearing loss and Kawasaki disease: a prospective study. Am J Otolaryngol 2001;22:343-8. https://doi.org/10.1053/ajot.2001.26495
  5. Novo A, Pinto S, Prior AC, Alvares S, Soares T, Guedes M. Kawasaki disease and sensorineural hearing loss: an (un)expected complication. Eur J Pediatr 2012;171:851-4. https://doi.org/10.1007/s00431-011-1667-3
  6. Kara A, Besbas N, Tezer H, Karagoz T, Devrim I, Unal OF. Reversible sensorineural hearing loss in a girl with Kawasaki disease. Turk J Pediatr 2007;49:431-3.
  7. Sundel RP, Cleveland SS, Beiser AS, Newburger JW, McGill T, Baker AL, et al. Audiologic profiles of children with Kawasaki disease. Am J Otol 1992;13:512-5.
  8. Magalhaes CM, Magalhaes Alves NR, Oliveira KM, Silva IM, Gandolfi L, Pratesi R. Sensorineural hearing loss: an underdiagnosed complication of Kawasaki disease. J Clin Rheumatol 2010;16:322-5. https://doi.org/10.1097/RHU.0b013e3181f603bc
  9. Sundel RP, Newburger JW, McGill T, Cleveland SS, Miller WW, Berry B, et al. Sensorineural hearing loss associated with Kawasaki disease. J Pediatr 1990;117:371-7. https://doi.org/10.1016/S0022-3476(05)81075-3
  10. Alves NR, Magalhaes CM, Almeida Rde F, Santos RC, Gandolfi L, Pratesi R. Prospective study of Kawasaki disease complications: review of 115 cases. Rev Assoc Med Bras 2011;57:295-300. https://doi.org/10.1016/S0104-4230(11)70062-8
  11. Clausen H, Howarth C, Giardini A. Kawasaki disease: always straight to the heart? BMJ Case Rep 2012 Aug 24 [Epub]. http:// dx.doi.org/10.1136/bcr-2012-006505.
  12. Research Committee on Kawasaki Disease. Report of subcommittee on standardization of diagnostic criteria and reporting of coronary artery lesions in Kawasaki disease. Tokyo: Ministry of Health and Welfare; 1984.
  13. Clark JG. Uses and abuses of hearing loss classification. ASHA 1981;23:493-500.
  14. Kato H, Koike S, Yamamoto M, Ito Y, Yano E. Coronary aneurysms in infants and young children with acute febrile mucocutaneous lymph node syndrome. J Pediatr 1975;86:892-8. https://doi.org/10.1016/S0022-3476(75)80220-4
  15. Newburger JW, Takahashi M, Beiser AS, Burns JC, Bastian J, Chung KJ, et al. A single intravenous infusion of gamma globulin as compared with four infusions in the treatment of acute Kawasaki syndrome. N Engl J Med 1991;324:1633-9. https://doi.org/10.1056/NEJM199106063242305
  16. Takagi K, Umezawa T, Saji T, Morooka K, Matsuo N. Meningoencephalitis in Kawasaki disease. No To Hattatsu 1990;22:429-35.
  17. Terasawa K, Ichinose E, Matsuishi T, Kato H. Neurological complications in Kawasaki disease. Brain Dev 1983;5:371-4. https://doi.org/10.1016/S0387-7604(83)80041-2
  18. Silva CH, Roscoe IC, Fernandes KP, Novaes RM, Lazari CS. Sensorineural hearing loss associated to Kawasaki Disease. J Pediatr (Rio J) 2002;78:71-4.
  19. Suzuki H, Yanagawa T, Kihira S. Two cases of hearing loss associated with Kawasaki disease. Clin Pediatr 1988;41:167-72.
  20. Smith KA, Yunker WK. Kawasaki disease is associated with sensorineural hearing loss: a systematic review. Int J Pediatr Otorhinolaryngol 2014;78:1216-20. https://doi.org/10.1016/j.ijporl.2014.05.026
  21. Brien JA. Ototoxicity associated with salicylates: a brief review. Drug Saf 1993;9:143-8. https://doi.org/10.2165/00002018-199309020-00006
  22. Myers EN, Bernstein JM. Salicylate ototoxicity; a clinical and experimental study. Arch Otolaryngol 1965;82:483-93. https://doi.org/10.1001/archotol.1965.00760010485006
  23. Day RO, Graham GG, Bieri D, Brown M, Cairns D, Harris G, et al. Concentration-response relationships for salicylate-induced ototoxicity in normal volunteers. Br J Clin Pharmacol 1989;28:695-702. https://doi.org/10.1111/j.1365-2125.1989.tb03562.x
  24. Kakehata S, Santos-Sacchi J. Effects of salicylate and lanthanides on outer hair cell motility and associated gating charge. J Neurosci 1996;16:4881-9. https://doi.org/10.1523/JNEUROSCI.16-16-04881.1996
  25. Lue AJ, Brownell WE. Salicylate induced changes in outer hair cell lateral wall stiffness. Hear Res 1999;135:163-8. https://doi.org/10.1016/S0378-5955(99)00102-1
  26. Oliver D, He DZ, Klocker N, Ludwig J, Schulte U, Waldegger S, et al. Intracellular anions as the voltage sensor of prestin, the outer hair cell motor protein. Science 2001;292:2340-3. https://doi.org/10.1126/science.1060939
  27. Zheng J, Shen W, He DZ, Long KB, Madison LD, Dallos P. Prestin is the motor protein of cochlear outer hair cells. Nature 2000;405:149-55. https://doi.org/10.1038/35012009

피인용 문헌

  1. Sensorineural hearing loss in Kawasaki disease vol.9, pp.2, 2016, https://doi.org/10.4103/0974-2069.180676
  2. Kawasaki disease: characteristics, diagnosis, and unusual presentations vol.15, pp.10, 2019, https://doi.org/10.1080/1744666x.2019.1659726
  3. Long-term hearing and neurodevelopmental outcomes following Kawasaki disease: A population-based cohort study vol.43, pp.7, 2015, https://doi.org/10.1016/j.braindev.2021.03.001