References
- Abedin, M.J., Nguyen, A., Jiang, N., Perry, C.E., Shelton, J.M., Watson, D.K., and Ferdous, A. (2014). Fli1 acts downstream of Etv2 to govern cell survival and vascular homeostasis via positive autoregulation. Circ. Res. 114, 1690-1699. https://doi.org/10.1161/CIRCRESAHA.1134303145
- Bartel, F.O., Higuchi, T., and Spyropoulos, D.D. (2000). Mouse models in the study of the Ets family of transcription factors. Oncogene 19, 6443-6454. https://doi.org/10.1038/sj.onc.1204038
- Barton, K., Muthusamy, N., Fischer, C., Ting, C.N., Walunas, T.L., Lanier, L.L., and Leiden, J.M. (1998). The Ets-1 transcription factor is required for the development of natural killer cells in mice. Immunity 9, 555-563. https://doi.org/10.1016/S1074-7613(00)80638-X
- Behrens, A.N., Zierold, C., Shi, X., Ren, Y., Koyano-Nakagawa, N., Garry, D.J., and Martin, C.M. (2014). Sox7 is regulated by ETV2 during cardiovascular development. Stem Cells Dev. 23, 2004-2013. https://doi.org/10.1089/scd.2013.0525
- Berman, H.M., Westbrook, J., Feng, Z., Gilliland, G., Bhat, T.N., Weissig, H., Shindyalov, I.N., and Bourne, P.E. (2000). The Protein Data Bank. Nucleic Acids Res. 28, 235-242. https://doi.org/10.1093/nar/28.1.235
- Bertrand, J.Y., Chi, N.C., Santoso, B., Teng, S., Stainier, D.Y., and Traver, D. (2010). Haematopoietic stem cells derive directly from aortic endothelium during development. Nature 464, 108-111. https://doi.org/10.1038/nature08738
- Boisset, J.C., van Cappellen, W., Andrieu-Soler, C., Galjart, N., Dzierzak, E., and Robin, C. (2010). In vivo imaging of haematopoietic cells emerging from the mouse aortic endothelium. Nature 464, 116-120. https://doi.org/10.1038/nature08764
- Bondue, A., Lapouge, G., Paulissen, C., Semeraro, C., Iacovino, M., Kyba, M., and Blanpain, C. (2008). Mesp1 acts as a master regulator of multipotent cardiovascular progenitor specification. Cell Stem Cell 3, 69-84. https://doi.org/10.1016/j.stem.2008.06.009
- Brown, T.A., and McKnight, S.L. (1992). Specificities of proteinprotein and protein-DNA interaction of GABP alpha and two newly defined ets-related proteins. Genes Dev. 6, 2502-2512. https://doi.org/10.1101/gad.6.12b.2502
- Caprioli, A., Koyano-Nakagawa, N., Iacovino, M., Shi, X., Ferdous, A., Harvey, R.P., Olson, E.N., Kyba, M., and Garry, D.J. (2011). Nkx2-5 represses Gata1 gene expression and modulates the cellular fate of cardiac progenitors during embryogenesis. Circulation 123, 1633-1641. https://doi.org/10.1161/CIRCULATIONAHA.110.008185
- Carmeliet, P., and Jain, R.K. (2011). Molecular mechanisms and clinical applications of angiogenesis. Nature 473, 298-307. https://doi.org/10.1038/nature10144
- Choi, K. (2002). The hemangioblast: a common progenitor of hematopoietic and endothelial cells. J. Hematother. Stem Cell Res. 11, 91-101. https://doi.org/10.1089/152581602753448568
- Chung, Y.S., Zhang, W.J., Arentson, E., Kingsley, P.D., Palis, J., and Choi, K. (2002). Lineage analysis of the hemangioblast as defined by FLK1 and SCL expression. Development 129, 5511-5520. https://doi.org/10.1242/dev.00149
- Ciau-Uitz, A., Wang, L., Patient, R., and Liu, F. (2013). ETS transcription factors in hematopoietic stem cell development. Blood Cells Mol. Dis. 51, 248-255. https://doi.org/10.1016/j.bcmd.2013.07.010
- Cohen, D.E., and Melton, D. (2011). Turning straw into gold: directing cell fate for regenerative medicine. Nat. Rev. Genet. 12, 243-252. https://doi.org/10.1038/nrg2938
- Craig, M.P., Grajevskaja, V., Liao, H.K., Balciuniene, J., Ekker, S.C., Park, J.S., Essner, J.J., Balciunas, D., and Sumanas, S. (2015). Etv2 and fli1b function together as key regulators of vasculogenesis and angiogenesis. Arterioscler. Thromb. Vasc. Biol. 35, 865-876. https://doi.org/10.1161/ATVBAHA.114.304768
- De Haro, L., and Janknecht, R. (2002). Functional analysis of the transcription factor ER71 and its activation of the matrix metalloproteinase-1 promoter. Nucleic Acids Res. 30, 2972-2979. https://doi.org/10.1093/nar/gkf390
- De Haro, L., and Janknecht, R. (2005). Cloning of the murine ER71 gene (Etsrp71) and initial characterization of its promoter. Genomics 85, 493-502. https://doi.org/10.1016/j.ygeno.2004.12.003
- De Val, S., Chi, N.C., Meadows, S.M., Minovitsky, S., Anderson, J.P., Harris, I.S., Ehlers, M.L., Agarwal, P., Visel, A., Xu, S.M., et al. (2008). Combinatorial regulation of endothelial gene expression by ets and forkhead transcription factors. Cell 135, 1053-1064. https://doi.org/10.1016/j.cell.2008.10.049
- Dejana, E., Taddei, A., and Randi, A.M. (2007). Foxs and Ets in the transcriptional regulation of endothelial cell differentiation and angiogenesis. Biochim. Biophys. ACTA 1775, 298-312.
- Drake, C.J., and Fleming, P.A. (2000). Vasculogenesis in the day 6.5 to 9.5 mouse embryo. Blood 95, 1671-1679.
- Ema, M., Faloon, P., Zhang, W.J., Hirashima, M., Reid, T., Stanford, W.L., Orkin, S., Choi, K., and Rossant, J. (2003). Combinatorial effects of Flk1 and Tal1 on vascular and hematopoietic development in the mouse. Genes Dev. 17, 380-393. https://doi.org/10.1101/gad.1049803
- Ema, M., Takahashi, S., and Rossant, J. (2006). Deletion of the selection cassette, but not cis-acting elements, in targeted Flk1-lacZ allele reveals Flk1 expression in multipotent mesodermal progenitors. Blood 107, 111-117. https://doi.org/10.1182/blood-2005-05-1970
- Faloon, P., Arentson, E., Kazarov, A., Deng, C.X., Porcher, C., Orkin, S., and Choi, K. (2000). Basic fibroblast growth factor positively regulates hematopoietic development. Development 127, 1931-1941.
- Ferdous, A., Caprioli, A., Iacovino, M., Martin, C.M., Morris, J., Richardson, J.A., Latif, S., Hammer, R.E., Harvey, R.P., Olson, E.N., et al. (2009). Nkx2-5 transactivates the Ets-related protein 71 gene and specifies an endothelial/endocardial fate in the developing embryo. Proc. Natl. Acad. Sci. USA 106, 814-819. https://doi.org/10.1073/pnas.0807583106
- Findlay, V.J., LaRue, A.C., Turner, D.P., Watson, P.M., and Watson, D.K. (2013). Understanding the role of ETS-mediated gene regulation in complex biological processes. Adv. Cancer Res. 119, 1-61. https://doi.org/10.1016/B978-0-12-407190-2.00001-0
- Flamme, I., Frolich, T., and Risau, W. (1997). Molecular mechanisms of vasculogenesis and embryonic angiogenesis. J. Cell. Physiol. 173, 206-210. https://doi.org/10.1002/(SICI)1097-4652(199711)173:2<206::AID-JCP22>3.0.CO;2-C
- Frum, T., and Ralston, A. (2015). Cell signaling and transcription factors regulating cell fate during formation of the mouse blastocyst. Trends Genet. 31, 402-410. https://doi.org/10.1016/j.tig.2015.04.002
- Ginsberg, M., James, D., Ding, B.S., Nolan, D., Geng, F., Butler, J.M., Schachterle, W., Pulijaal, V.R., Mathew, S., Chasen, S.T., et al. (2012). Efficient direct reprogramming of mature amniotic cells into endothelial cells by ETS factors and TGFbeta suppression. Cell 151, 559-575. https://doi.org/10.1016/j.cell.2012.09.032
- Gurdon, J.B. (2006). From nuclear transfer to nuclear reprogramming: the reversal of cell differentiation. Ann. Rev. Cell Devel. Biol. 22, 1-22. https://doi.org/10.1146/annurev.cellbio.22.090805.140144
- Haar, J.L., and Ackerman, G.A. (1971). A phase and electron microscopic study of vasculogenesis and erythropoiesis in the yolk sac of the mouse. The Anatomical Record 170, 199-223. https://doi.org/10.1002/ar.1091700206
- Han, J.K., Chang, S.H., Cho, H.J., Choi, S.B., Ahn, H.S., Lee, J., Jeong, H., Youn, S.W., Lee, H.J., Kwon, Y.W., et al. (2014). Direct conversion of adult skin fibroblasts to endothelial cells by defined factors. Circulation 130, 1168-1178. https://doi.org/10.1161/CIRCULATIONAHA.113.007727
- Hart, A., Melet, F., Grossfeld, P., Chien, K., Jones, C., Tunnacliffe, A., Favier, R., and Bernstein, A. (2000). Fli-1 is required for murine vascular and megakaryocytic development and is hemizygously deleted in patients with thrombocytopenia. Immunity 13, 167-177. https://doi.org/10.1016/S1074-7613(00)00017-0
- Hatakeyama, J., and Kageyama, R. (2004). Retinal cell fate determination and bHLH factors. Semin. Cell Devel. Biol. 15, 83-89. https://doi.org/10.1016/j.semcdb.2003.09.005
- Hayashi, M., Pluchinotta, M., Momiyama, A., Tanaka, Y., Nishikawa, S., and Kataoka, H. (2012). Endothelialization and altered hematopoiesis by persistent Etv2 expression in mice. Exp. Hematol. 40, 738-750 e711. https://doi.org/10.1016/j.exphem.2012.05.012
- Hirata, H., Kawamata, S., Murakami, Y., Inoue, K., Nagahashi, A., Tosaka, M., Yoshimura, N., Miyamoto, Y., Iwasaki, H., Asahara, T., et al. (2007). Coexpression of platelet-derived growth factor receptor alpha and fetal liver kinase 1 enhances cardiogenic potential in embryonic stem cell differentiation in vitro. J. Biosci. Bioeng. 103, 412-419. https://doi.org/10.1263/jbb.103.412
- Hollenhorst, P.C., Jones, D.A., and Graves, B.J. (2004). Expression profiles frame the promoter specificity dilemma of the ETS family of transcription factors. Nucleic Acids Res. 32, 5693-5702. https://doi.org/10.1093/nar/gkh906
- Hollenhorst, P.C., McIntosh, L.P., and Graves, B.J. (2011). Genomic and biochemical insights into the specificity of ETS transcription factors. Ann. Rev. Biochem. 80, 437-471. https://doi.org/10.1146/annurev.biochem.79.081507.103945
- Huang, P., He, Z., Ji, S., Sun, H., Xiang, D., Liu, C., Hu, Y., Wang, X., and Hui, L. (2011). Induction of functional hepatocyte-like cells from mouse fibroblasts by defined factors. Nature 475, 386-389. https://doi.org/10.1038/nature10116
- Ieda, M., Fu, J.D., Delgado-Olguin, P., Vedantham, V., Hayashi, Y., Bruneau, B.G., and Srivastava, D. (2010). Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors. Cell 142, 375-386. https://doi.org/10.1016/j.cell.2010.07.002
- Iwafuchi-Doi, M., and Zaret, K.S. (2014). Pioneer transcription factors in cell reprogramming. Genes Dev. 28, 2679-2692. https://doi.org/10.1101/gad.253443.114
- Jain, R.K. (2003). Molecular regulation of vessel maturation. Nat. Med. 9, 685-693. https://doi.org/10.1038/nm0603-685
- Johnson, N.C., Dillard, M.E., Baluk, P., McDonald, D.M., Harvey, N.L., Frase, S.L., and Oliver, G. (2008). Lymphatic endothelial cell identity is reversible and its maintenance requires Prox1 activity. Genes Dev. 22, 3282-3291. https://doi.org/10.1101/gad.1727208
- Kataoka, H., Hayashi, M., Nakagawa, R., Tanaka, Y., Izumi, N., Nishikawa, S., Jakt, M.L., Tarui, H., and Nishikawa, S. (2011). Etv2/ER71 induces vascular mesoderm from Flk1+PDGFRalpha+ primitive mesoderm. Blood 118, 6975-6986. https://doi.org/10.1182/blood-2011-05-352658
- Kim, H., Nguyen, V.P., Petrova, T.V., Cruz, M., Alitalo, K., and Dumont, D.J. (2010). Embryonic vascular endothelial cells are malleable to reprogramming via Prox1 to a lymphatic gene signature. BMC Dev. Biol. 10, 72. https://doi.org/10.1186/1471-213X-10-72
- Kim, J.Y., Lee, R.H., Kim, T.M., Kim, D.W., Jeon, Y.J., Huh, S.H., Oh, S.Y., Kyba, M., Kataoka, H., Choi, K., et al. (2014). OVOL2 is a critical regulator of ER71/ETV2 in generating FLK1+, hematopoietic, and endothelial cells from embryonic stem cells. Blood 124, 2948-2952. https://doi.org/10.1182/blood-2014-03-556332
- Kissa, K., and Herbomel, P. (2010). Blood stem cells emerge from aortic endothelium by a novel type of cell transition. Nature 464, 112-115. https://doi.org/10.1038/nature08761
- Knoepfler, P.S. (2009). Deconstructing stem cell tumorigenicity: a roadmap to safe regenerative medicine. Stem Cells 27, 1050-1056. https://doi.org/10.1002/stem.37
- Kodandapani, R., Pio, F., Ni, C.Z., Piccialli, G., Klemsz, M., McKercher, S., Maki, R.A., Ely, K.R. (1996). A new pattern for helix-turn-helix recognition revealed by the PU.1 ETS-domain-DNA complex. Nature 380, 456-460. https://doi.org/10.1038/380456a0
- Koyano-Nakagawa, N., Kweon, J., Iacovino, M., Shi, X., Rasmussen, T.L., Borges, L., Zirbes, K.M., Li, T., Perlingeiro, R.C., Kyba, M., et al. (2012). Etv2 is expressed in the yolk sac hematopoietic and endothelial progenitors and regulates Lmo2 gene expression. Stem Cells 30, 1611-1623. https://doi.org/10.1002/stem.1131
- Kume, T., Jiang, H., Topczewska, J.M., and Hogan, B.L. (2001). The murine winged helix transcription factors, Foxc1 and Foxc2, are both required for cardiovascular development and somitogenesis. Genes Dev. 15, 2470-2482. https://doi.org/10.1101/gad.907301
- Lee, D., Park, C., Lee, H., Lugus, J.J., Kim, S.H., Arentson, E., Chung, Y.S., Gomez, G., Kyba, M., Lin, S., et al. (2008). ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and vessel progenitor specification. Cell Stem Cell 2, 497-507. https://doi.org/10.1016/j.stem.2008.03.008
- Lee, D., Kim, T., and Lim, D.S. (2011). The Er71 is an important regulator of hematopoietic stem cells in adult mice. Stem Cells 29, 539-548. https://doi.org/10.1002/stem.597
- Lee, S., Park, C., Han, J.W., Kim, J.Y., Cho, K., Kim, E.J., Kim, S., Lee, S.-J., An, H.J., Sin, M.Y., et al. (2014). Abstract 18205: Direct Reprogramming of Human Dermal Fibroblasts into Endothelial Cells Using a Single Transcription Factor. Circulation 130, A18205.
- Lindsley, R.C., Gill, J.G., Murphy, T.L., Langer, E.M., Cai, M., Mashayekhi, M., Wang, W., Niwa, N., Nerbonne, J.M., Kyba, M., et al. (2008). Mesp1 coordinately regulates cardiovascular fate restriction and epithelial-mesenchymal transition in differentiating ESCs. Cell Stem Cell 3, 55-68. https://doi.org/10.1016/j.stem.2008.04.004
- Liu, F., Kang, I., Park, C., Chang, L.W., Wang, W., Lee, D., Lim, D.S., Vittet, D., Nerbonne, J.M., and Choi, K. (2012). ER71 specifies Flk-1+ hemangiogenic mesoderm by inhibiting cardiac mesoderm and Wnt signaling. Blood 119, 3295-3305. https://doi.org/10.1182/blood-2012-01-403766
- Liu, F., Bhang, S.H., Arentson, E., Sawada, A., Kim, C.K., Kang, I., Yu, J., Sakurai, N., Kim, S.H., Yoo, J.J., et al. (2013). Enhanced hemangioblast generation and improved vascular repair and regeneration from embryonic stem cells by defined transcription factors. Stem Cell Rep. 1, 166-182. https://doi.org/10.1016/j.stemcr.2013.06.005
- Liu, F., Li, D., Yu, Y.Y., Kang, I., Cha, M.J., Kim, J.Y., Park, C., Watson, D.K., Wang, T., and Choi, K. (2015). Induction of hematopoietic and endothelial cell program orchestrated by ETS transcription factor ER71/ETV2. EMBO Rep. 16, 654-669. https://doi.org/10.15252/embr.201439939
- Lugus, J.J., Chung, Y.S., Mills, J.C., Kim, S.I., Grass, J., Kyba, M., Doherty, J.M., Bresnick, E.H., and Choi, K. (2007). GATA2 functions at multiple steps in hemangioblast development and differentiation. Development 134, 393-405. https://doi.org/10.1242/dev.02731
- Lyons, I., Parsons, L.M., Hartley, L., Li, R., Andrews, J.E., Robb, L., and Harvey, R.P. (1995). Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5. Genes Dev. 9, 1654-1666. https://doi.org/10.1101/gad.9.13.1654
- Meadows, S.M., Myers, C.T., and Krieg, P.A. (2011). Regulation of endothelial cell development by ETS transcription factors. Semin. Cell Dev. Biol. 22, 976-984. https://doi.org/10.1016/j.semcdb.2011.09.009
- Moore, J.C., Sheppard-Tindell, S., Shestopalov, I.A., Yamazoe, S., Chen, J.K., and Lawson, N.D. (2013). Post-transcriptional mechanisms contribute to Etv2 repression during vascular development. Dev. Biol. 384, 128-140. https://doi.org/10.1016/j.ydbio.2013.08.028
- Morita, R., Suzuki, M., Kasahara, H., Shimizu, N., Shichita, T., Sekiya, T., Kimura, A., Sasaki, K., Yasukawa, H., and Yoshimura, A. (2015). ETS transcription factor ETV2 directly converts human fibroblasts into functional endothelial cells. Proc. Natl. Acad. Sci. USA 112, 160-165. https://doi.org/10.1073/pnas.1413234112
- Motoike, T., Markham, D.W., Rossant, J., and Sato, T.N. (2003). Evidence for novel fate of Flk1+ progenitor: contribution to muscle lineage. Genesis 35, 153-159. https://doi.org/10.1002/gene.10175
- Mozaffarian, D., Benjamin, E.J., Go, A.S., Arnett, D.K., Blaha, M.J., Cushman, M., de Ferranti, S., Despres, J.P., Fullerton, H.J., Howard, V.J., et al. (2015). Heart disease and stroke statistics--2015 update: a report from the American Heart Association. Circulation 131, e29-322. https://doi.org/10.1161/CIR.0000000000000152
- Neuhaus, H., Muller, F., and Hollemann, T. (2010). Xenopus er71 is involved in vascular development. Dev. Dyn. 239, 3436-3445. https://doi.org/10.1002/dvdy.22487
- Palencia-Desai, S., Kohli, V., Kang, J., Chi, N.C., Black, B.L., and Sumanas, S. (2011). Vascular endothelial and endocardial progenitors differentiate as cardiomyocytes in the absence of Etsrp/Etv2 function. Development 138, 4721-4732. https://doi.org/10.1242/dev.064998
- Palis, J., Robertson, S., Kennedy, M., Wall, C., and Keller, G. (1999). Development of erythroid and myeloid progenitors in the yolk sac and embryo proper of the mouse. Development 126, 5073-5084.
- Pang, Z.P., Yang, N., Vierbuchen, T., Ostermeier, A., Fuentes, D.R., Yang, T.Q., Citri, A., Sebastiano, V., Marro, S., Sudhof, T.C., et al. (2011). Induction of human neuronal cells by defined transcription factors. Nature 476, 220-223. https://doi.org/10.1038/nature10202
- Park, C., Kim, T.M., and Malik, A.B. (2013). Transcriptional regulation of endothelial cell and vascular development. Circ. Res. 112, 1380-1400. https://doi.org/10.1161/CIRCRESAHA.113.301078
- Park, C., Lee, T.J., Bhang, S.H., Liu, F., Nakamura, R., Oladipupo, S.S., Pitha-Rowe, I., Capoccia, B., Choi, H.S., Kim, T.M., et al. (2015). Injury-Mediated Vascular Regeneration Requires Endothelial ER71/ETV2. Arteriosclerosis, thrombosis, and vascular biology. Nov 19. pii: ATVBAHA.115.306430. [Epub ahead of print]
- Patan, S. (2004). Vasculogenesis and angiogenesis. Cancer Treat. Res. 117, 3-32. https://doi.org/10.1007/978-1-4419-8871-3_1
- Pham, V.N., Lawson, N.D., Mugford, J.W., Dye, L., Castranova, D., Lo, B., and Weinstein, B.M. (2007). Combinatorial function of ETS transcription factors in the developing vasculature. Dev. Biol. 303, 772-783. https://doi.org/10.1016/j.ydbio.2006.10.030
- Randi, A.M., Sperone, A., Dryden, N.H., and Birdsey, G.M. (2009). Regulation of angiogenesis by ETS transcription factors. Biochem. Soc. Trans. 37, 1248-1253. https://doi.org/10.1042/BST0371248
- Rasmussen, T.L., Kweon, J., Diekmann, M.A., Belema-Bedada, F., Song, Q., Bowlin, K., Shi, X., Ferdous, A., Li, T., Kyba, M., et al. (2011). ER71 directs mesodermal fate decisions during embryogenesis. Development 138, 4801-4812. https://doi.org/10.1242/dev.070912
- Sakurai, H., Era, T., Jakt, L.M., Okada, M., Nakai, S., Nishikawa, S., and Nishikawa, S. (2006). In vitro modeling of paraxial and lateral mesoderm differentiation reveals early reversibility. Stem Cells 24, 575-586. https://doi.org/10.1634/stemcells.2005-0256
- Schoenebeck, J.J., Keegan, B.R., and Yelon, D. (2007). Vessel and blood specification override cardiac potential in anterior mesoderm. Dev. Cell 13, 254-267. https://doi.org/10.1016/j.devcel.2007.05.012
- Sekiya, S., and Suzuki, A. (2011). Direct conversion of mouse fibroblasts to hepatocyte-like cells by defined factors. Nature 475, 390-393. https://doi.org/10.1038/nature10263
- Seo, S., Fujita, H., Nakano, A., Kang, M., Duarte, A., and Kume, T. (2006). The forkhead transcription factors, Foxc1 and Foxc2, are required for arterial specification and lymphatic sprouting during vascular development. Dev. Biol. 294, 458-470. https://doi.org/10.1016/j.ydbio.2006.03.035
- Sharrocks, A.D. (2001). The ETS-domain transcription factor family. Nat. Rev. Mol. Cell. Biol. 2, 827-837. https://doi.org/10.1038/35099076
- Shi, X., Richard, J., Zirbes, K.M., Gong, W., Lin, G., Kyba, M., Thomson, J.A., Koyano-Nakagawa, N., and Garry, D.J. (2014). Cooperative interaction of Etv2 and Gata2 regulates the development of endothelial and hematopoietic lineages. Dev. Biol. 389, 208-218. https://doi.org/10.1016/j.ydbio.2014.02.018
- Shi, X., Zirbes, K.M., Rasmussen, T.L., Ferdous, A., Garry, M.G., Koyano-Nakagawa, N., and Garry, D.J. (2015). The transcription factor Mesp1 interacts with cAMP-responsive element binding protein 1 (Creb1) and coactivates Ets variant 2 (Etv2) gene expression. J. Biol. Chem. 290, 9614-9625. https://doi.org/10.1074/jbc.M114.614628
- Simoes, F.C., Peterkin, T., and Patient, R. (2011). Fgf differentially controls cross-antagonism between cardiac and haemangioblast regulators. Development 138, 3235-3245. https://doi.org/10.1242/dev.059634
- Song, K., Nam, Y.J., Luo, X., Qi, X., Tan, W., Huang, G.N., Acharya, A., Smith, C.L., Tallquist, M.D., Neilson, E.G., et al. (2012). Heart repair by reprogramming non-myocytes with cardiac transcription factors. Nature 485, 599-604. https://doi.org/10.1038/nature11139
- Spyropoulos, D.D., Pharr, P.N., Lavenburg, K.R., Jackers, P., Papas, T.S., Ogawa, M., and Watson, D.K. (2000). Hemorrhage, impaired hematopoiesis, and lethality in mouse embryos carrying a targeted disruption of the Fli1 transcription factor. Mol. Cell. Biol. 20, 5643-5652. https://doi.org/10.1128/MCB.20.15.5643-5652.2000
- Stainier, D.Y., Weinstein, B.M., Detrich, H.W., 3rd, Zon, L.I., and Fishman, M.C. (1995). Cloche, an early acting zebrafish gene, is required by both the endothelial and hematopoietic lineages. Development 121, 3141-3150.
- Stenman, J.M., Rajagopal, J., Carroll, T.J., Ishibashi, M., McMahon, J., and McMahon, A.P. (2008). Canonical Wnt signaling regulates organ-specific assembly and differentiation of CNS vasculature. Science 322, 1247-1250. https://doi.org/10.1126/science.1164594
- Sumanas, S., and Lin, S. (2006). Ets1-related protein is a key regulator of vasculogenesis in zebrafish. PLoS Biol. 4, e10.
- Sumanas, S., Jorniak, T., and Lin, S. (2005). Identification of novel vascular endothelial-specific genes by the microarray analysis of the zebrafish cloche mutants. Blood 106, 534-541. https://doi.org/10.1182/blood-2004-12-4653
- Takahashi, K., and Yamanaka, S. (2006). Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126, 663-676. https://doi.org/10.1016/j.cell.2006.07.024
- Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., and Yamanaka, S. (2007). Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131, 861-872. https://doi.org/10.1016/j.cell.2007.11.019
- Takeuchi, M., Fuse, Y., Watanabe, M., Andrea, C.S., Takeuchi, M., Nakajima, H., Ohashi, K., Kaneko, H., Kobayashi-Osaki, M., Yamamoto, M., et al. (2015). LSD1/KDM1A promotes hematopoietic commitment of hemangioblasts through downregulation of Etv2. Proc. Natl. Acad. Sci. USA 112, 13922-13927. https://doi.org/10.1073/pnas.1517326112
- Tanaka, M., Chen, Z., Bartunkova, S., Yamasaki, N., and Izumo, S. (1999). The cardiac homeobox gene Csx/Nkx2.5 lies genetically upstream of multiple genes essential for heart development. Development 126, 1269-1280.
- Tsai, F.Y., and Orkin, S.H. (1997). Transcription factor GATA-2 is required for proliferation/survival of early hematopoietic cells and mast cell formation, but not for erythroid and myeloid terminal differentiation. Blood 89, 3636-3643.
- Tsai, F.Y., Keller, G., Kuo, F.C., Weiss, M., Chen, J., Rosenblatt, M., Alt, F.W., and Orkin, S.H. (1994). An early haematopoietic defect in mice lacking the transcription factor GATA-2. Nature 371, 221-226. https://doi.org/10.1038/371221a0
- Unezaki, S., Horai, R., Sudo, K., Iwakura, Y., and Ito, S. (2007). Ovol2/Movo, a homologue of Drosophila ovo, is required for angiogenesis, heart formation and placental development in mice. Genes Cells 12, 773-785.
- Veldman, M.B., and Lin, S. (2012). Etsrp/Etv2 is directly regulated by Foxc1a/b in the zebrafish angioblast. Circ. Res. 110, 220-229. https://doi.org/10.1161/CIRCRESAHA.111.251298
- Veldman, M.B., Zhao, C., Gomez, G.A., Lindgren, A.G., Huang, H., Yang, H., Yao, S., Martin, B.L., Kimelman, D., and Lin, S. (2013). Transdifferentiation of fast skeletal muscle into functional endothelium in vivo by transcription factor Etv2. PLoS Biol. 11, e1001590. https://doi.org/10.1371/journal.pbio.1001590
- Verger, A., and Duterque-Coquillaud, M. (2002). When Ets transcription factors meet their partners. Bioessays 24, 362-370. https://doi.org/10.1002/bies.10068
- Vierbuchen, T., Ostermeier, A., Pang, Z.P., Kokubu, Y., Sudhof, T.C., and Wernig, M. (2010). Direct conversion of fibroblasts to functional neurons by defined factors. Nature 463, 1035-1041. https://doi.org/10.1038/nature08797
- Waddington, C.H. (1957). The strategy of the genes; a discussion of some aspects of theoretical biology (London,: Allen & Unwin).
- Wang, L.C., Kuo, F., Fujiwara, Y., Gilliland, D.G., Golub, T.R., and Orkin, S.H. (1997). Yolk sac angiogenic defect and intraembryonic apoptosis in mice lacking the Ets-related factor TEL. EMBO J. 16, 4374-4383. https://doi.org/10.1093/emboj/16.14.4374
- Wei, G., Srinivasan, R., Cantemir-Stone, C.Z., Sharma, S.M., Santhanam, R., Weinstein, M., Muthusamy, N., Man, A.K., Oshima, R.G., Leone, G., et al. (2009). Ets1 and Ets2 are required for endothelial cell survival during embryonic angiogenesis. Blood 114, 1123-1130. https://doi.org/10.1182/blood-2009-03-211391
- Weintraub, H., Tapscott, S.J., Davis, R.L., Thayer, M.J., Adam, M.A., Lassar, A.B., and Miller, A.D. (1989). Activation of muscle-specific genes in pigment, nerve, fat, liver, and fibroblast cell lines by forced expression of MyoD. Proc. Natl. Acad. Sci. USA 86, 5434-5438. https://doi.org/10.1073/pnas.86.14.5434
- Weintraub, H., Davis, R., Tapscott, S., Thayer, M., Krause, M., Benezra, R., Blackwell, T.K., Turner, D., Rupp, R., Hollenberg, S., et al. (1991). The myoD gene family: nodal point during specification of the muscle cell lineage. Science 251, 761-766. https://doi.org/10.1126/science.1846704
- Xie, H., Ye, M., Feng, R., and Graf, T. (2004). Stepwise reprogramming of B cells into macrophages. Cell 117, 663-676. https://doi.org/10.1016/S0092-8674(04)00419-2
- Yamamizu, K., Matsunaga, T., Katayama, S., Kataoka, H., Takayama, N., Eto, K., Nishikawa, S., and Yamashita, J.K. (2012). PKA/CREB signaling triggers initiation of endothelial and hematopoietic cell differentiation via Etv2 induction. Stem Cells 30, 687-696. https://doi.org/10.1002/stem.1041
- Yamashita, J., Itoh, H., Hirashima, M., Ogawa, M., Nishikawa, S., Yurugi, T., Naito, M., Nakao, K., and Nishikawa, S. (2000). Flk1-positive cells derived from embryonic stem cells serve as vascular progenitors. Nature 408, 92-96. https://doi.org/10.1038/35040568
- Zovein, A.C., Hofmann, J.J., Lynch, M., French, W.J., Turlo, K.A., Yang, Y., Becker, M.S., Zanetta, L., Dejana, E., Gasson, J.C., et al. (2008). Fate tracing reveals the endothelial origin of hematopoietic stem cells. Cell Stem Cell 3, 625-636. https://doi.org/10.1016/j.stem.2008.09.018
Cited by
- ETV-2 activated proliferation of endothelial cells and attenuated acute hindlimb ischemia in mice vol.53, pp.7, 2017, https://doi.org/10.1007/s11626-017-0151-4
- Etv2 as an essential regulator of mesodermal lineage development 2017, https://doi.org/10.1093/cvr/cvx133
- The Hemogenic Competence of Endothelial Progenitors Is Restricted by Runx1 Silencing during Embryonic Development vol.15, pp.10, 2016, https://doi.org/10.1016/j.celrep.2016.05.001
- Direct Reprogramming of Human Dermal Fibroblasts Into Endothelial Cells Using ER71/ETV2 vol.120, pp.5, 2017, https://doi.org/10.1161/CIRCRESAHA.116.309833
- FLI1 and PKC co-activation promote highly efficient differentiation of human embryonic stem cells into endothelial-like cells vol.9, pp.2, 2018, https://doi.org/10.1038/s41419-017-0162-9
- Transcriptional and epigenomic landscapes of CNS and non-CNS vascular endothelial cells vol.7, pp.2050-084X, 2018, https://doi.org/10.7554/eLife.36187
- Adventitial Sca1+ Cells Transduced With ETV2 Are Committed to the Endothelial Fate and Improve Vascular Remodeling After Injury vol.38, pp.1, 2018, https://doi.org/10.1161/ATVBAHA.117.309853
- In vivo transduction of ETV2 improves cardiac function and induces vascular regeneration following myocardial infarction vol.51, pp.2, 2019, https://doi.org/10.1038/s12276-019-0206-6
- Etv2-miR-130a-Jarid2 cascade regulates vascular patterning during embryogenesis vol.12, pp.12, 2015, https://doi.org/10.1371/journal.pone.0189010
- Regenerating the Cardiovascular System Through Cell Reprogramming; Current Approaches and a Look Into the Future vol.5, pp.None, 2015, https://doi.org/10.3389/fcvm.2018.00109
- Conversion of human adipose-derived stem cells into functional and expandable endothelial-like cells for cell-based therapies vol.9, pp.1, 2015, https://doi.org/10.1186/s13287-018-1088-6
- Tobacco Heating System 2.2 has a limited impact on DNA methylation of candidate enhancers in mouse lung compared with cigarette smoke vol.123, pp.None, 2019, https://doi.org/10.1016/j.fct.2018.11.020
- Taiji: System-level identification of key transcription factors reveals transcriptional waves in mouse embryonic development vol.5, pp.3, 2015, https://doi.org/10.1126/sciadv.aav3262
- C-kit signaling promotes human pre-implantation 3PN embryonic development and blastocyst formation vol.17, pp.None, 2015, https://doi.org/10.1186/s12958-019-0521-8
- Spatiotemporal Gene Coexpression and Regulation in Mouse Cardiomyocytes of Early Cardiac Morphogenesis vol.8, pp.15, 2015, https://doi.org/10.1161/jaha.119.012941
- Endothelial Cell Development and Its Application to Regenerative Medicine vol.125, pp.4, 2015, https://doi.org/10.1161/circresaha.119.311405
- ETV2/ER71 regulates the generation of FLK1+ cells from mouse embryonic stem cells through miR-126-MAPK signaling vol.10, pp.1, 2019, https://doi.org/10.1186/s13287-019-1466-8
- A Computational Model of the Endothelial to Mesenchymal Transition vol.11, pp.None, 2015, https://doi.org/10.3389/fgene.2020.00040
- The lateral plate mesoderm vol.147, pp.12, 2015, https://doi.org/10.1242/dev.175059
- The next generation of endothelial differentiation: Tissue-specific ECs vol.28, pp.7, 2021, https://doi.org/10.1016/j.stem.2021.05.002
- In Silico Analysis to Explore Lineage-Independent and -Dependent Transcriptional Programs Associated with the Process of Endothelial and Neural Differentiation of Human Induced Pluripotent Stem Cells vol.10, pp.18, 2015, https://doi.org/10.3390/jcm10184161
- OCT4-mediated inflammation induces cell reprogramming at the origin of cardiac valve development and calcification vol.7, pp.45, 2015, https://doi.org/10.1126/sciadv.abf7910
- Fibroblast transition to an endothelial “trans” state improves cell reprogramming efficiency vol.11, pp.1, 2021, https://doi.org/10.1038/s41598-021-02056-x
- Multi-omics analyses of early liver injury reveals cell-type-specific transcriptional and epigenomic shift vol.22, pp.1, 2021, https://doi.org/10.1186/s12864-021-08173-1