Korean Journal of Clinical Laboratory Science (대한임상검사과학회지)

Korean Society for Clinical Laboratory Science (대한임상검사과학회)
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Association between Thyroid Hormone and Risk Factors of Metabolic Syndrome in Adult Men of Normal Thyroid Function

정상 갑상샘 기능을 보이는 성인 남성에서 갑상샘 호르몬과 대사증후군 위험요인과의 관계

  • Shin, Kyung-A (Department of Clinical Laboratory Science, Shinsung University)
  • Received : 2015.09.01
  • Accepted : 2015.10.22
  • Published : 2015.12.30
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Abstract

Thyroid hormones are essential for cellular energy homeostasis and regulation by interacting with the sympathetic nervous system. This study was conducted to investigate the relationship between thyroid hormone and risk factors of metabolic syndrome for medical checkups of male patients. The study subjects were 12,250 males between 20~80 years old who visited the hospital for a health check-up at one General Hospital in Gyeonggi-do during the period of January 2011 to December 2013. According to the American Heart Association/National Heart, Lung, and Blood Institute (AHA/NHLBI), the metabolic syndrome criteria is defined as the presence of 3 or more risk factors. FT4 was lower in the metabolic syndrome group than in the normal group (p<0.001). The level of FT4 decreased as the levels of abdominal obesity (p=0.001), hypertriglyceridemia (p<0.001), blood pressure (p=0.005) and blood glucose (p=0.005) increased. The TSH level increased hypertriglyceridemia (p=0.047). FT4 had an influence on the waist circumference and triglyceride (p<0.001). HbA1c, insulin, HOMA-IR, hs-CRP were higher in the lowest quartile than in the highest quartile (p<0.001). FT4 had effects on the waist circumference and triglyceride, but TSH had no effect on metabolic syndrome risk factors. The metabolic syndrome was lower in the highest quartile of FT4 than in its lowest quartile.

갑상샘 호르몬은 교감신경계와의 상호작용으로 세포의 에너지 대사조절 및 항상성 유지에 중요한 역할을 한다. 본 연구는 건강검진을 실시한 성인 남성을 대상으로 갑상샘 호르몬과 대사증후군 위험요인간의 연관성을 밝히고자 하였다. 경기지역 일개 종합병원에서 2011년 1월부터 2013년 12월까지 건강검진센터에서 종합건강검진을 실시한 20세 이상 80세 이하의 남성 12,250명을 대상으로 하였다. 대사증후군은 American Heart Association/National Heart, Lung, and Blood Institute (AHA/NHLBI, 2005)에서 제시한 진단 기준에 따랐으며, 3개 이상의 위험요인을 가진 경우 대사증후군으로 진단하였다. 정상군보다 대사증후군 진단군에서 FT4가 낮았으며(p<0.001), TSH는 대사증후군 유무에 따른 차이는 없었다. 또한 FT4는 대사증후군 위험요인 중 허리둘레, 중성지방에 영향을 미치는 것으로 나타났으며(각각 p<0.001), FT4의 가장 낮은 사분위수가 가장 높은 사분위수보다 HbA1c, 인슐린, HOMA-IR, hs-CRP 농도가 높았다(각각 p<0.001). FT4는 허리둘레, 중성지방에 영향을 미치는 것으로 나타났으나, TSH는 대사증후군 위험요인에 영향을 미치지 않는 것으로 나타났다. 또한 FT4의 가장 높은 분위수의 대사증후군 발생위험이 가장 낮은 분위수보다 낮게 나타났다.

Keywords

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