Korean Journal of Clinical Laboratory Science (대한임상검사과학회지)

Korean Society for Clinical Laboratory Science (대한임상검사과학회)
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A Study on the Relationship between Carotid Artery Intima-Media Thickness and Clinical Chemistry Tests

경동맥 초음파 결과와 임상화학 검사의 상관성 연구

  • Kim, Dae-Sik (Department of Clinical Laboratory Science, Dongnam Health University) ;
  • Sung, Hyun-Ho (Department of Clinical Laboratory Science, Dongnam Health University) ;
  • Cho, Eun-kyung (Department of Clinical Laboratory Science, Dongnam Health University) ;
  • Lee, Jong-Woo (Department of Laboratory Medicine, Korea University Ansan Hospital)
  • 김대식 (동남보건대학교 임상병리과) ;
  • 성현호 (동남보건대학교 임상병리과) ;
  • 조은경 (동남보건대학교 임상병리과) ;
  • 이종우 (고려대학교 안산병원 진단검사의학과)
  • Received : 2015.10.14
  • Accepted : 2015.11.09
  • Published : 2015.12.30
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Abstract

Carotid Intima-Media Thickness (CIMT) testing is a test that precisely assesses cerebrovascular and coronary heart diseases. According to many previous studies, CIMT predicts atherosclerosis and is highly correlated to cardiovascular disease risk factors. It has also been reported that CIMT is an independent predictor of risk factors for myocardial infarction and stroke. Therefore, the purpose of this study is to investigate CIMT and other independent factors through a correlation study with the clinical laboratory test results of a blood test. As a result, this study could not prove the correlation between CIMT and risk factors of cardiovascular disease (TC, TG, LDL cholesterol, and HDL cholesterol) due to an insufficient number of subjects. Nevertheless, a positive correlation was demonstrated between CIMT and ALT (p<0.05), GGT (p<0.05), Uric acid (p<0.05), and CEA (p<0.05) at a statistically significant level, suggesting a continuation of the study.

경동맥 내중막 두께는 뇌혈관질환과 관상동맥질환을 정밀하게 측정하는 검사이다. 많은 선행논문에 따르면 경동맥 내중막 두께는 죽상동맥경화를 예측하고 심혈관질환의 위험인자와 연관성이 높으며, 심근경색이나 뇌졸중 발생 위험을 예측할 수 있는 독립인자로 연구되었다. 따라서 본 연구는 혈액검사 중 임상화학적 검사결과와의 상관관계 연구를 통해 경동맥 내중막 두께와 다른 독립인자를 확보하는 것이 목적이었다. 연구결과 피험자의 부족으로 인해 심혈관계관련 임상화학적 요인과는 상관관계를 입증하지 못했으나, 경동맥 내중막 두께와 ALT (p<0.05), GGT (p<0.05), Uric acid (p<0.05), CEA (p<0.05)와 양의 상관관계를 통계적인 유의수준으로 입증하여 지속적인 연구의 문제를 제기하였다.

Keywords

References

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