한국임상약학회지 (Korean Journal of Clinical Pharmacy)

  • 제25권4호
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  • Pages.273-279
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  • 2015
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  • 1226-6051(pISSN)
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  • 2508-786X(eISSN)
한국임상약학회 (Korean College Of Clinical Pharmacy)
권호 표지

건강보험자료를 이용한 12세 미만 소아에서 코데인 처방양상평가

Prescribing Patterns of Codeine among Children under Aged 12 in Korea

  • 박효주 (한국의약품안전관리원) ;
  • 신한나 (건강보험심사평가원 심사평가연구소) ;
  • 신주영 (맥길대학교 역학.통계 및 직업환경의학과)
  • Park, Hyo-Ju (Korea Institute of Drug Safety and Risk Management) ;
  • Shin, Han-Na (Review and Assessment Research Institute, Korea Health Insurance Review and Assessment Service) ;
  • Shin, Ju-Young (Department of Epidemiology, Biostatistics, and Occupational Health, McGill University)
  • 투고 : 2015.11.11
  • 심사 : 2015.12.02
  • 발행 : 2015.12.31
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초록

Objective: Codeine may result in death or respiratory depression in children, particularly who are rapid metabolizer of CYP2D6, therefore it should be used cautiously among children under 12 years of age. This study was to investigate the prescribing pattern of codeine among children according to the age group, prescribed diagnosis, type of medical service and medical specialties. Method: We used Korea Health Insurance Review and Assessment Service-National Patient Sample (HIRA-NPS) database. Study subjects included inpatients or outpatients, who were prescribed codeine between January, 1, 2011 and December, 31, 2011. Contraindicated use of codeine was defined as the use of codeine at least one times under aged 12. Age groups were subclassified according to the <2 years, 2-4 years, 5-8 years, and 9-11 years. Frequently prescribed diagnosis (ICD-10), type of medical service, and medical specialties were also described among codeine users under aged 12. Results: Codeine users were 6,411 inpatients (9,958 prescriptions), and 3,397 outpatients (6,258 prescriptions), respectively. Codeine prescription under 12 years of age were 2.1% (210 prescriptions) among inpatients, and 12.3% (776 prescriptions) among outpatients (p-value<0.05). Outpatient prescriptions of codeine under 12 aged were issued mostly from primary care clinics and frequent diagnosis were unspecified bronchopneumonia (51.6%), and vasomotor rhinitis (23.7%). Conclusion: This study found prescribing of codeine under 12 aged is common in outpatient and primary clinics. Nationwide and community-based efforts should be needed to reduce inappropriate prescribing among children.

키워드

참고문헌

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