Korean Journal of Head & Neck Oncology (대한두경부종양학회지)

The Korean Society for Head and Neck Oncology (대한두경부종양학회)
권호 표지

Clinical Manifestations of Papillary Thyroid Carcinoma Recurred as Distant Metastases

원격 전이로 재발한 갑상선 유두암에 대한 임상적 고찰

  • Kim, Nam Young (Department of Otorhinolaryngology-Head and Neck Surgery, Korea Cancer Center Hospital) ;
  • Kim, Kyoung Hun (Department of Otorhinolaryngology-Head and Neck Surgery, Korea Cancer Center Hospital) ;
  • Park, Sung Ho (Department of Otorhinolaryngology-Head and Neck Surgery, Korea Cancer Center Hospital) ;
  • Lee, Guk Haeng (Department of Otorhinolaryngology-Head and Neck Surgery, Korea Cancer Center Hospital) ;
  • Lee, Byeong Cheol (Department of Otorhinolaryngology-Head and Neck Surgery, Korea Cancer Center Hospital) ;
  • Lee, Myung-Chul (Department of Otorhinolaryngology-Head and Neck Surgery, Korea Cancer Center Hospital) ;
  • Choi, Ik Joon (Department of Otorhinolaryngology-Head and Neck Surgery, Korea Cancer Center Hospital)
  • 김남영 (한국원자력의학원 원자력병원 이비인후-두경부외과) ;
  • 김경헌 (한국원자력의학원 원자력병원 이비인후-두경부외과) ;
  • 박성호 (한국원자력의학원 원자력병원 이비인후-두경부외과) ;
  • 이국행 (한국원자력의학원 원자력병원 이비인후-두경부외과) ;
  • 이병철 (한국원자력의학원 원자력병원 이비인후-두경부외과) ;
  • 이명철 (한국원자력의학원 원자력병원 이비인후-두경부외과) ;
  • 최익준 (한국원자력의학원 원자력병원 이비인후-두경부외과)
  • Received : 2015.09.23
  • Accepted : 2015.10.31
  • Published : 2015.11.30
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Abstract

Background and Objectives: This study aimed to analyze the features of patients with papillary thyroid carcinoma (PTC) recurred as distant metastases (DM). Materials and Method: We retrospectively reviewed and analyzed clinical records of 63 patients who were treated for PTC recurred as DM between 2000 and 2006. Univariate and multivariate analyses of various clinical factors were performed. Results: Male patients were 12, and female patients were 51. The 5- and 10-year survival rates for PTC recurred as DM were 85% and 73%, respectively. Size of tumor, multiplicity of tumor, lateral neck node metastasis, and RAI ablation therapy with other treatments such as surgery were associated with survival rate (p < 0.005) in univariate analysis. The lateral neck node metastasis[p =0.039, hazard ratio=2.2(95% CI. 1.18~3.24)] and multiple organ DM[p =0.041, hazard ratio=2.18(95% CI. 1.03~2.89)] were related to the survival in multivariate analysis. Conclusion: PTC recurred as DM is uncommon (2.2%). The size of tumor, the multiplicity of tumor, lateral neck node metastasis and RAI ablation therapy with other treatments for DM were revealed as associated factors for the survival. Evaluation of DM should be considered in patients with PTC during long-term follow-up.

Keywords

References

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