Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Whole Brain Radiotherapy Combined with Stereotactic Radiosurgery versus Stereotactic Radiosurgery Alone for Brain Metastases

  • Adas, Yasemin Guzle (Radiation Oncology Department, Ankara Oncology Training and Research Hospital) ;
  • Yazici, Omer (Radiation Oncology Department, Ankara Oncology Training and Research Hospital) ;
  • Kekilli, Esra (Radiation Oncology Department, Ankara Oncology Training and Research Hospital) ;
  • Akkas, Ebru Atasever (Radiation Oncology Department, Ankara Oncology Training and Research Hospital) ;
  • Karakaya, Ebru (Radiation Oncology Department, Ankara Oncology Training and Research Hospital) ;
  • Ucer, Ali Riza (Radiation Oncology Department, Ankara Oncology Training and Research Hospital) ;
  • Ertas, Gulcin (Radiation Oncology Department, Ankara Oncology Training and Research Hospital) ;
  • Calikoglu, Tamer (Radiation Oncology Department, Ankara Oncology Training and Research Hospital) ;
  • Elgin, Yesim (Radiation Oncology Department, Ankara Oncology Training and Research Hospital) ;
  • Inan, Gonca Altinisik (Radiation Oncology Department, Ankara Oncology Training and Research Hospital) ;
  • Kocer, Ali Mert (Radiation Oncology Department, Ankara Oncology Training and Research Hospital) ;
  • Guney, Yildiz (Radiation Oncology Department, Ankara Oncology Training and Research Hospital)
  • Published : 2015.12.03
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Abstract

Background: The aim of this study was to evaluate the effect of whole brain radiotherapy (WBRT) combined with streotactic radiosurgery versus stereotactic radiosurgery (SRS) alone for patients with brain metastases. Materials and Methods: This was a retrospective study that evaluated the results of 46 patients treated for brain metastases at Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Radiation Oncology Department, between January 2012 and January 2015. Twenty-four patients were treated with WBRT+SRS while 22 patients were treated with only SRS. Results: Time to local recurrence was 9.7 months in the WBRT+SRS arm and 8.3 months in SRS arm, the difference not being statistically significant (p=0.7). Local recurrence rate was higher in the SRS alone arm but again without significance (p=0,06). Conclusions: In selected patient group with limited number (one to four) of brain metastases SRS alone can be considered as a treatment option and WBRT may be omitted in the initial treatment.

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References

  1. Abe E, Aoyama H (2012). The role of whole brain radiation therapy for management of brain metastases in era of stereotactic radiosurgery. Curr Oncol Rep, 14, 79-84 https://doi.org/10.1007/s11912-011-0201-0
  2. Akhavan A, Binesh F, Heidari S (2014). Survival of metastatic patients in Yazd, Iran. Asian Pac J Cancer Prev, 15, 3571-4 https://doi.org/10.7314/APJCP.2014.15.8.3571
  3. Aoyama H, Tago M, Kato N, et al (2006). Neurocognitive function of patients with brain metastasis who received either whole brain radiotherapy plus stereotactic radiosurgery or radiosurgery alone. Int J Radiat Oncol Biol Phys, 68, 1388-95
  4. Duan L, Zeng R, Yang KH, et al (2014) Whole Brain Radiotherapy Combined with Stereotactic Radiotherapy Versus Stereotactic Radiotherapy Alone for Brain Metastases: a Meta-analysis. Asian Pac J Cancer Prev, 15, 911-5 https://doi.org/10.7314/APJCP.2014.15.2.911
  5. Fabi A, Felici A, Metro G, et al (2011). Brain metastases from solid tumors: disease outcome according to type of treatment and therapeutic resources of the treating center. J Exp Clin Cancer Res, 30, 10. https://doi.org/10.1186/1756-9966-30-10
  6. Gaspar EL, Mehta MP, PAtchell RA, et al (2010). The role of whole brain radiation therapy in the management of newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline. J Neurooncol, 96, 17-32 https://doi.org/10.1007/s11060-009-0060-9
  7. Kocher M, Soffietti R, Abacioglu U, et al (2011). Adjuvan Whole-Brain radiotherapy versus observation after radiosurgery or surgical resection of one to three cerebral metastases: results of the EORTC 22952-26001 Study. J Clin Oncol, 29, 134-141 https://doi.org/10.1200/JCO.2010.30.1655
  8. Linskey ME, Andrews DW, Asher AL, et al (2010). The role of stereotactic radiosurgery in the management of patients with newlly diagnosed brain metastases: a systemic review and evidence-based clinical practice guidline. J Neurooncol, 96, 45-68 https://doi.org/10.1007/s11060-009-0073-4
  9. Mctyre E, Scott J, Chinnaiyan P (2013). Whole brain radiotherapy for brain metastasis. Surg Neurol Int, 4, 236-44 https://doi.org/10.4103/2152-7806.111301
  10. Patchell RA, Tibbs PA, Walsh JW et al (1990). A randomized trial of surgery in the treatment of single metastases to the brain. N Engl J med, 322, 494-500 https://doi.org/10.1056/NEJM199002223220802
  11. Phungrassami T, Sriplung H (2015) Radiotherapy for brain metastases in southern Thailand: workload, treatment pattern and survival. Asian Pac J Cancer Prev, 16, 1435-42. https://doi.org/10.7314/APJCP.2015.16.4.1435
  12. Song WG, Wang YF, Wang Rl, et al (2013). Therapeutic Regimens and Prognostic Factors of Brain Metastatic Cancers. Asian Pac J Cancer Prev, 14, 923-7 https://doi.org/10.7314/APJCP.2013.14.2.923
  13. Sundstrom JT, Minn H, Lertola KK et al.(1998) Prognosis of patients treated for intracranial metastases with whole-brain irradiation, Ann Med, 30, 296-9. https://doi.org/10.3109/07853899809005858