Asian Pacific Journal of Cancer Prevention

  • 제15권19호
  • /
  • Pages.8183-8189
  • /
  • 2014
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  • 1513-7368(pISSN)
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  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
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High Serum Level of Retinol and α-Tocopherol Affords Protection Against Oral Cancer in a Multiethnic Population

  • Athirajan, Vimmitra (Oral Cancer Research & Coordinating Centre, Faculty of Dentistry, University Malaya) ;
  • Razak, Ishak Abdul (Oral Cancer Research & Coordinating Centre, Faculty of Dentistry, University Malaya) ;
  • Thurairajah, Nalina (Centre of Pre-U Studies, UCSI University) ;
  • Ghani, Wan Maria Nabillah (Oral Cancer Research & Coordinating Centre, Faculty of Dentistry, University Malaya) ;
  • Ching, Helen-Ng Lee (Oral Cancer Research & Coordinating Centre, Faculty of Dentistry, University Malaya) ;
  • Yang, Yi-Hsin (Department of Dental Hygiene, College of Dental Medicine, Kaohsiung Medical University) ;
  • Peng, Karen-Ng Lee (Oral Cancer Research & Coordinating Centre, Faculty of Dentistry, University Malaya) ;
  • Rahman, Zainal Ariff Abdul (Department of Oral-Maxillofacial Surgical and Medical Sciences, Faculty of Dentistry, University Malaya) ;
  • Mustafa, Wan Mahadzir Wan (Oral Health Division, Ministry of Health Malaysia) ;
  • Abraham, Mannil Thomas (Oral Health Division, Ministry of Health Malaysia) ;
  • Kiong, Tay Keng (Oral Health Division, Ministry of Health Malaysia) ;
  • Mun, Yuen Kar (Oral Health Division, Ministry of Health Malaysia) ;
  • Jalil, Norma (Oral Health Division, Ministry of Health Malaysia) ;
  • Zain, Rosnah Binti (Oral Cancer Research & Coordinating Centre, Faculty of Dentistry, University Malaya)
  • 발행 : 2014.10.23
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초록

Background: A comparative cross-sectional study involving oral cancer patients and healthy individuals was designed to investigate associations between retinol, ${\alpha}$-tocopherol and ${\beta}$-carotene with the risk of oral cancer. Materials and Methods: This study included a total of 240 matched cases and controls where subjects were selected from the Malaysian Oral Cancer Database and Tissue Bank System (MOCDTBS). Retinol, ${\alpha}$-tocopherol and ${\beta}$-carotene levels and intake were examined by high-performance liquid chromatography (HPLC) and food frequency questionnaire (FFQ) respectively. Results: It was found that results from the two methods applied did not correlate, so that further analysis was done using the HPLC method utilising blood serum. Serum levels of retinol and ${\alpha}$-tocopherol among cases ($0.177{\pm}0.081$, $1.649{\pm}1.670{\mu}g/ml$) were significantly lower than in controls ($0.264{\pm}0.137$, $3.225{\pm}2.054{\mu}g/ml$) (p<0.005). Although serum level of ${\beta}$-carotene among cases ($0.106{\pm}0.159{\mu}g/ml$) were lower compared to controls ($0.134{\pm}0.131{\mu}g/ml$), statistical significance was not observed. Logistic regression analysis showed that high serum level of retinol (OR=0.501, 95% CI=0.254-0.992, p<0.05) and ${\alpha}$-tocopherol (OR=0.184, 95% CI=0.091-0.370, p<0.05) was significantly related to lower risk of oral cancer, whereas no relationship was observed between ${\beta}$-carotene and oral cancer risk. Conclusions: High serum levels of retinol and ${\alpha}$-tocopherol confer protection against oral cancer risk.

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