The Korean Journal of Medicine

The Korean Association of Internal Medicine (대한내과학회)
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Diagnosis and Management of Central Venous Catheter-Related Infections

중심정맥관 관련 감염의 진단과 치료

  • Park, Ki-Ho (Department of Internal Medicine, Kyung Hee University College of Medicine)
  • 박기호 (경희대학교 의과대학 내과학교실)
  • Published : 2014.03.01
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Abstract

Use of central venous catheters (CVCs) can lead to catheter-related bloodstream infections (CRBSIs) and such infections are associated with serious morbidity and mortality and with increased health care costs. The diagnosis of CRBSI needs to be accurate for adequate management. Semiquantitative catheter tip culture has been established as standard in most laboratories, but this method requires catheter removal. Catheter-sparing diagnostic methods, such as differential quantitative blood cultures and differential time to positivity have emerged as reliable diagnostic techniques. Management of CRBSIs involves deciding on catheter removal and the type and duration of systemic antimicrobial therapy. Such decisions depend on the identity of the organism causing the bloodstream infection and the clinical and radiographic manifestations suggesting a complicated course.

Keywords

References

  1. O'Grady NP, Alexander M, Dellinger EP, et al. Guidelines for the prevention of intravascular catheter-related infections: Centers for Disease Control and Prevention. MMWR Recomm Rep 2002;51:1-29.
  2. Mermel LA. Prevention of intravascular catheter-related infections. Ann Intern Med 2000;132:391-402. https://doi.org/10.7326/0003-4819-132-5-200003070-00009
  3. Rello J, Ochagavia A, Sabanes E, et al. Evaluation of outcome of intravenous catheter-related infections in critically ill patients. Am J Respir Crit Care Med 2000;162:1027-1030. https://doi.org/10.1164/ajrccm.162.3.9911093
  4. Dimick JB, Pelz RK, Consunji R, Swoboda SM, Hendrix CW, Lipsett PA. Increased resource use associated with catheter-related bloodstream infection in the surgical intensive care unit. Arch Surg 2001;136:229-234. https://doi.org/10.1001/archsurg.136.2.229
  5. Fagan RP, Edwards JR, Park BJ, Fridkin SK, Magill SS. Incidence trends in pathogen-specific central line-associated bloodstream infections in US intensive care units, 1990-2010. Infect Control Hosp Epidemiol 2013;34:893-899. https://doi.org/10.1086/671724
  6. Centers for Disease Control Prevention (CDC). Vital signs: central line-associated blood stream infections: United States, 2001, 2008, and 2009. MMWR Morb Mortal Wkly Rep 2011;60:243-248.
  7. Fontela PS, Platt RW, Rocher I, et al. Epidemiology of central line-associated bloodstream infections in Quebec intensive care units: a 6-year review. Am J Infect Control 2012;40:221-226. https://doi.org/10.1016/j.ajic.2011.04.008
  8. Kim OS, Kim SM. Prevention of central venous catheter-related infections. Korean J Nosocomial Infect Control 1999;4:35-40.
  9. Yoo S, Ha M, Choi D, Pai H. Effectiveness of surveillance of central catheter-related bloodstream infection in an ICU in Korea. Infect Control Hosp Epidemiol 2001;22:433-436. https://doi.org/10.1086/501930
  10. Yoo S, Jung SI, Kim GS, et al. Interventions to prevent catheter-associated blood-stream infections: a multicenter study in Korea. Infect Chemother 2010;42:216-222. https://doi.org/10.3947/ic.2010.42.4.216
  11. Jeong IS, Park SM, Lee JM, Song JY, Lee SJ. Effect of central line bundle on central line-associated bloodstream infections in intensive care units. Am J Infect Control 2013;41:710-716. https://doi.org/10.1016/j.ajic.2012.10.010
  12. Rosenthal VD, Bijie H, Maki DG, et al. International Nosocomial Infection Control Consortium (INICC) report, data summary of 36 countries, for 2004-2009. Am J Infect Control 2012;40:396-407. https://doi.org/10.1016/j.ajic.2011.05.020
  13. Mermel LA, Allon M, Bouza E, et al. Clinical practice guidelines for the diagnosis and management of intravascular catheter-related infection: 2009 update by the Infectious Diseases Society of America. Clin Infect Dis 2009;49:1-45. https://doi.org/10.1086/599376
  14. Mermel LA, Farr BM, Sherertz RJ, et al. Guidelines for the management of intravascular catheter-related infections. Clin Infect Dis 2001;32:1249-1272. https://doi.org/10.1086/320001
  15. Hentrich M, Schalk E, Schmidt-Hieber M, et al. Central venous catheter-related infections in hematology and oncology: 2012 updated guidelines on diagnosis, management and prevention by the Infectious Diseases Working Party of the German Society of Hematology and Medical Oncology. Ann Oncol 2014. doi: 10.1093/annonc/mdt545.
  16. Fatkenheuer G, Buchheidt D, Cornely OA, et al. Central venous catheter (CVC)-related infections in neutropenic patients: guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO). Ann Hematol 2003;82(Suppl 2):S149-157. https://doi.org/10.1007/s00277-003-0769-z
  17. Vanholder R, Canaud B, Fluck R, et al. Diagnosis, prevention and treatment of haemodialysis catheter-related bloodstream infections (CRBSI): a position statement of European Renal Best Practice (ERBP). NDT Plus 2010;3:234-246.
  18. Bouza E, Burillo A, Guembe M. Managing intravascular catheter-related infections in heart transplant patients: how far can we apply IDSA guidelines for immunocompromised patients? Curr Opin Infect Dis 2011;24:302-308. https://doi.org/10.1097/QCO.0b013e328348b1b9
  19. Jeon MH, Park WB, Kim SR, et al. Korean nosocomial infections surveillance system, intensive care unit module report: data summary from July 2010 through June 2011. Korean J Nosocomial Infect Control 2012;17:28-39.
  20. Snydman DR, Gorbea HF, Pober BR, Majka JA, Murray SA, Perry LK. Predictive value of surveillance skin cultures in total-parenteral-nutrition-related infection. Lancet 1982;2:1385-1388.
  21. Bjornson HS, Colley R, Bower RH, Duty VP, Schwartz-Fulton JT, Fischer JE. Association between microorganism growth at the catheter insertion site and colonization of the catheter in patients receiving total parenteral nutrition. Surgery 1982;92:720-727.
  22. Cooper GL, Hopkins CC. Rapid diagnosis of intravascular catheter-associated infection by direct Gram staining of catheter segments. N Engl J Med 1985;312:1142-1147. https://doi.org/10.1056/NEJM198505023121802
  23. Raad II, Baba M, Bodey GP. Diagnosis of catheter-related infections: the role of surveillance and targeted quantitative skin cultures. Clin Infect Dis 1995;20:593-597. https://doi.org/10.1093/clinids/20.3.593
  24. Guidet B, Nicola I, Barakett V, et al. Skin versus hub cultures to predict colonization and infection of central venous catheter in intensive care patients. Infection 1994;22:43-48. https://doi.org/10.1007/BF01780765
  25. Armstrong CW, Mayhall CG, Miller KB, et al. Clinical predictors of infection of central venous catheters used for total parenteral nutrition. Infect Control Hosp Epidemiol 1990;11:71-78. https://doi.org/10.2307/30144265
  26. Park KH, Kim SH, Song EH, et al. Development of bacteraemia or fungaemia after removal of colonized central venous catheters in patients with negative concomitant blood cultures. Clin Microbiol Infect 2010;16:742-746. https://doi.org/10.1111/j.1469-0691.2009.02926.x
  27. Peacock SJ, Eddleston M, Emptage A, King A, Crook DW. Positive intravenous line tip cultures as predictors of bacteraemia. J Hosp Infect 1998;40:35-38. https://doi.org/10.1016/S0195-6701(98)90022-6
  28. Wisplinghoff H, Bischoff T, Tallent SM, Seifert H, Wenzel RP, Edmond MB. Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study. Clin Infect Dis 2004;39:309-317. https://doi.org/10.1086/421946
  29. Linares J, Sitges-Serra A, Garau J, Perez JL, Martin R. Pathogenesis of catheter sepsis: a prospective study with quantitative and semiquantitative cultures of catheter hub and segments. J Clin Microbiol 1985;21:357-360.
  30. Tenney JH, Moody MR, Newman KA, et al. Adherent microorganisms on lumenal surfaces of long-term intravenous catheters: importance of Staphylococcus epidermidis in patients with cancer. Arch Intern Med 1986;146:1949-1954. https://doi.org/10.1001/archinte.1986.00360220101019
  31. Mermel LA, McCormick RD, Springman SR, Maki DG. The pathogenesis and epidemiology of catheter-related infection with pulmonary artery Swan-Ganz catheters: a prospective study utilizing molecular subtyping. Am J Med 1991;91:197S-205S. https://doi.org/10.1016/0002-9343(91)90369-9
  32. Safdar N, Maki DG. Inflammation at the insertion site is not predictive of catheter-related bloodstream infection with short-term, noncuffed central venous catheters. Crit Care Med 2002;30:2632-2635. https://doi.org/10.1097/00003246-200212000-00003
  33. Mayhall CG. Diagnosis and management of infections of implantable devices used for prolonged venous access. Curr Clin Top Infect Dis 1992;12:83-110.
  34. Walshe LJ, Malak SF, Eagan J, Sepkowitz KA. Complication rates among cancer patients with peripherally inserted central catheters. J Clin Oncol 2002;20:3276-3281. https://doi.org/10.1200/JCO.2002.11.135
  35. Guembe M, Rodriguez-Creixems M, Sanchez-Carrillo C, Perez-Parra A, Martin-Rabadan P, Bouza E. How many lumens should be cultured in the conservative diagnosis of catheter-related bloodstream infections? Clin Infect Dis 2010;50:1575-1579. https://doi.org/10.1086/652766
  36. Dobbins BM, Catton JA, Kite P, McMahon MJ, Wilcox MH. Each lumen is a potential source of central venous catheter-related bloodstream infection. Crit Care Med 2003;31:1688-1690. https://doi.org/10.1097/01.CCM.0000063257.04633.AE
  37. Maki DG, Weise CE, Sarafin HW. A semiquantitative culture method for identifying intravenous-catheter-related infection. N Engl J Med 1977;296:1305-1309. https://doi.org/10.1056/NEJM197706092962301
  38. Raad I, Davis S, Khan A, Tarrand J, Elting L, Bodey GP. Impact of central venous catheter removal on the recurrence of catheter-related coagulase-negative staphylococcal bacteremia. Infect Control Hosp Epidemiol 1992;13:215-221. https://doi.org/10.2307/30147100
  39. Safdar N, Fine JP, Maki DG. Meta-analysis: methods for diagnosing intravascular device-related bloodstream infection. Ann Intern Med 2005;142:451-466. https://doi.org/10.7326/0003-4819-142-6-200503150-00011
  40. Tomlinson D, Mermel LA, Ethier MC, Matlow A, Gillmeister B, Sung L. Defining bloodstream infections related to central venous catheters in patients with cancer: a systematic review. Clin Infect Dis 2011;53:697-710. https://doi.org/10.1093/cid/cir523
  41. Raad I, Hanna HA, Alakech B, Chatzinikolaou I, Johnson MM, Tarrand J. Differential time to positivity: a useful method for diagnosing catheter-related bloodstream infections. Ann Intern Med 2004;140:18-25. https://doi.org/10.7326/0003-4819-140-1-200401060-00007
  42. Blot F, Nitenberg G, Chachaty E, et al. Diagnosis of catheter-related bacteraemia: a prospective comparison of the time to positivity of hub-blood versus peripheral-blood cultures. Lancet 1999;354:1071-1077. https://doi.org/10.1016/S0140-6736(98)11134-0
  43. Abdelkefi A, Achour W, Ben Othman T, et al. Difference in time to positivity is useful for the diagnosis of catheter-related bloodstream infection in hematopoietic stem cell transplant recipients. Bone Marrow Transplant 2005;35:397-401. https://doi.org/10.1038/sj.bmt.1704773
  44. Seifert H, Cornely O, Seggewiss K, et al. Bloodstream infection in neutropenic cancer patients related to short-term nontunnelled catheters determined by quantitative blood cultures, differential time to positivity, and molecular epidemiological typing with pulsed-field gel electrophoresis. J Clin Microbiol 2003;41:118-123. https://doi.org/10.1128/JCM.41.1.118-123.2003
  45. Nucci M, Anaissie E. Revisiting the source of candidemia: skin or gut? Clin Infect Dis 2001;33:1959-1967. https://doi.org/10.1086/323759
  46. Bouza E, Alcala L, Munoz P, et al. Can microbiologists help to assess catheter involvement in candidaemic patients before removal? Clin Microbiol Infect 2013;19:E129-135. https://doi.org/10.1111/1469-0691.12096
  47. Park KH, Lee YM, Hong HL, et al. Persistent catheter-related Staphylococcus aureus bacteremia after catheter removal and initiation of antimicrobial therapy. PLoS One 2012;7:e46389. https://doi.org/10.1371/journal.pone.0046389
  48. Raad II, Sabbagh MF. Optimal duration of therapy for catheter-related Staphylococcus aureus bacteremia: a study of 55 cases and review. Clin Infect Dis 1992;14:75-82. https://doi.org/10.1093/clinids/14.1.75
  49. Park KH, Cho OH, Lee SO, et al. Outcome of attempted Hickman catheter salvage in febrile neutropenic cancer patients with Staphylococcus aureus bacteremia. Ann Hematol 2010;89:1163-1169. https://doi.org/10.1007/s00277-010-1004-3
  50. Kim SH, Kang CI, Kim HB, et al. Outcomes of Hickman catheter salvage in febrile neutropenic cancer patients with Staphylococcus aureus bacteremia. Infect Control Hosp Epidemiol 2003;24:897-904. https://doi.org/10.1086/502157
  51. Fowler VG Jr, Justice A, Moore C, et al. Risk factors for hematogenous complications of intravascular catheter-associated Staphylococcus aureus bacteremia. Clin Infect Dis 2005;40:695-703. https://doi.org/10.1086/427806
  52. Elting LS, Bodey GP. Septicemia due to Xanthomonas species and non-aeruginosa Pseudomonas species: increasing incidence of catheter-related infections. Medicine (Baltimore) 1990;69:296-306. https://doi.org/10.1097/00005792-199009000-00003
  53. Wilcox MH, Tack KJ, Bouza E, et al. Complicated skin and skin-structure infections and catheter-related bloodstream infections: noninferiority of linezolid in a phase 3 study. Clin Infect Dis 2009;48:203-212. https://doi.org/10.1086/595686
  54. Lorente L, Jimenez A, Santana M, et al. Microorganisms responsible for intravascular catheter-related bloodstream infection according to the catheter site. Crit Care Med 2007;35:2424-2427. https://doi.org/10.1097/01.CCM.0000284589.63641.B8
  55. Rijnders BJ, Van Wijngaerden E, Vandecasteele SJ, Stas M, Peetermans WE. Treatment of long-term intravascular catheter-related bacteraemia with antibiotic lock: randomized, placebo-controlled trial. J Antimicrob Chemother 2005;55:90-94. https://doi.org/10.1093/jac/dkh488
  56. Fortun J, Grill F, Martin-Davila P, et al. Treatment of longterm intravascular catheter-related bacteraemia with antibiotic-lock therapy. J Antimicrob Chemother 2006;58:816-821. https://doi.org/10.1093/jac/dkl318
  57. Krzywda EA, Andris DA, Edmiston CE Jr, Quebbeman EJ. Treatment of Hickman catheter sepsis using antibiotic lock technique. Infect Control Hosp Epidemiol 1995;16:596-598. https://doi.org/10.2307/30141101
  58. Benoit JL, Carandang G, Sitrin M, Arnow P. Intraluminal antibiotic treatment of central venous catheter infections in patients receiving parenteral nutrition at home. Clin Infect Dis 1997;24:743-744.
  59. Arnow PM, Kushner R. Malassezia furfur catheter infection cured with antibiotic lock therapy. Am J Med 1991;90:128-130. https://doi.org/10.1016/0002-9343(91)90518-3
  60. Ghanem GA, Boktour M, Warneke C, et al. Catheter-related Staphylococcus aureus bacteremia in cancer patients: high rate of complications with therapeutic implications. Medicine (Baltimore) 2007;86:54-60. https://doi.org/10.1097/MD.0b013e318030d344
  61. Falagas ME, Vardakas KZ, Athanasiou S. Intravenous heparin in combination with antibiotics for the treatment of deep vein septic thrombophlebitis: a systematic review. Eur J Pharmacol 2007;557:93-98. https://doi.org/10.1016/j.ejphar.2006.11.068
  62. Raad I, Kassar R, Ghannam D, Chaftari AM, Hachem R, Jiang Y. Management of the catheter in documented catheter-related coagulase-negative staphylococcal bacteremia: remove or retain? Clin Infect Dis 2009;49:1187-1194. https://doi.org/10.1086/605694
  63. Fowler VG Jr, Sanders LL, Sexton DJ, et al. Outcome of Staphylococcus aureus bacteremia according to compliance with recommendations of infectious diseases specialists: experience with 244 patients. Clin Infect Dis 1998;27:478-486. https://doi.org/10.1086/514686
  64. Dugdale DC, Ramsey PG. Staphylococcus aureus bacteremia in patients with Hickman catheters. Am J Med 1990;89:137-141. https://doi.org/10.1016/0002-9343(90)90290-T
  65. Malanoski GJ, Samore MH, Pefanis A, Karchmer AW. Staphylococcus aureus catheter-associated bacteremia: minimal effective therapy and unusual infectious complications associated with arterial sheath catheters. Arch Intern Med 1995;155:1161-1166. https://doi.org/10.1001/archinte.1995.00430110069007
  66. Pigrau C, Rodriguez D, Planes AM, et al. Management of catheter-related Staphylococcus aureus bacteremia: when may sonographic study be unnecessary? Eur J Clin Microbiol Infect Dis 2003;22:713-719. https://doi.org/10.1007/s10096-003-1041-0
  67. Abraham J, Mansour C, Veledar E, Khan B, Lerakis S. Staphylococcus aureus bacteremia and endocarditis: the Grady Memorial Hospital experience with methicillin-sensitive S aureus and methicillin-resistant S aureus bacteremia. Am Heart J 2004;147:536-539. https://doi.org/10.1016/j.ahj.2003.09.018
  68. Fowler VG Jr, Li J, Corey GR, et al. Role of echocardiography in evaluation of patients with Staphylococcus aureus bacteremia: experience in 103 patients. J Am Coll Cardiol 1997;30:1072-1078. https://doi.org/10.1016/S0735-1097(97)00250-7
  69. Sullenberger AL, Avedissian LS, Kent SM. Importance of transesophageal echocardiography in the evaluation of Staphylococcus aureus bacteremia. J Heart Valve Dis 2005;14:23-28.
  70. Rosen AB, Fowler VG Jr, Corey GR, et al. Cost-effectiveness of transesophageal echocardiography to determine the duration of therapy for intravascular catheter-associated Staphylococcus aureus bacteremia. Ann Intern Med 1999;130:810-820. https://doi.org/10.7326/0003-4819-130-10-199905180-00004
  71. Nguyen MH, Peacock JE Jr, Tanner DC, et al. Therapeutic approaches in patients with candidemia: evaluation in a multicenter, prospective, observational study. Arch Intern Med 1995;155:2429-2435. https://doi.org/10.1001/archinte.1995.00430220087009
  72. Hung CC, Chen YC, Chang SC, Luh KT, Hsieh WC. Nosocomial candidemia in a university hospital in Taiwan. J Formos Med Assoc 1996;95:19-28.
  73. Rex JH, Bennett JE, Sugar AM, et al. Intravascular catheter exchange and duration of candidemia: NIAID Mycoses Study Group and the Candidemia Study Group. Clin Infect Dis 1995;21:994-996. https://doi.org/10.1093/clinids/21.4.994
  74. Nucci M, Colombo AL, Silveira F, et al. Risk factors for death in patients with candidemia. Infect Control Hosp Epidemiol 1998;19:846-850. https://doi.org/10.2307/30141563
  75. Almirante B, Rodriguez D, Park BJ, et al. Epidemiology and predictors of mortality in cases of Candida bloodstream infection: results from population-based surveillance, barcelona, Spain, from 2002 to 2003. J Clin Microbiol 2005;43:1829-1835. https://doi.org/10.1128/JCM.43.4.1829-1835.2005
  76. Raad I, Hanna H, Boktour M, et al. Management of central venous catheters in patients with cancer and candidemia. Clin Infect Dis 2004;38:1119-1127. https://doi.org/10.1086/382874
  77. Raad I, Hanna H, Maki D. Intravascular catheter-related infections: advances in diagnosis, prevention, and management. Lancet Infect Dis 2007;7:645-657. https://doi.org/10.1016/S1473-3099(07)70235-9
  78. Pappas PG, Kauffman CA, Andes D, et al. Clinical practice guidelines for the management of candidiasis: 2009 update by the Infectious Diseases Society of America. Clin Infect Dis 2009;48:503-535. https://doi.org/10.1086/596757
  79. Hanna H, Afif C, Alakech B, et al. Central venous catheter-related bacteremia due to gram-negative bacilli: significance of catheter removal in preventing relapse. Infect Control Hosp Epidemiol 2004;25:646-649. https://doi.org/10.1086/502455
  80. Norgaard M, Larsson H, Pedersen G, Schonheyder HC, Rothman KJ, Sorensen HT. Short-term mortality of bacteraemia in elderly patients with haematological malignancies. Br J Haematol 2006;132:25-31. https://doi.org/10.1111/j.1365-2141.2005.05845.x
  81. Hummel M, Warga C, Hof H, Hehlmann R, Buchheidt D. Diagnostic yield of blood cultures from antibiotic-naive and antibiotically treated patients with haematological malignancies and high-risk neutropenia. Scand J Infect Dis 2009;41:650-655. https://doi.org/10.1080/00365540903062150
  82. Wisplinghoff H, Seifert H, Wenzel RP, Edmond MB. Current trends in the epidemiology of nosocomial bloodstream infections in patients with hematological malignancies and solid neoplasms in hospitals in the United States. Clin Infect Dis 2003;36:1103-1110. https://doi.org/10.1086/374339
  83. Marcos M, Soriano A, Inurrieta A, et al. Changing epidemiology of central venous catheter-related bloodstream infections: increasing prevalence of Gram-negative pathogens. J Antimicrob Chemother 2011;66:2119-2125. https://doi.org/10.1093/jac/dkr231
  84. Elishoov H, Or R, Strauss N, Engelhard D. Nosocomial colonization, septicemia, and Hickman/Broviac catheter-related infections in bone marrow transplant recipients: a 5-year prospective study. Medicine (Baltimore) 1998;77:83-101. https://doi.org/10.1097/00005792-199803000-00002
  85. Nouwen JL, Wielenga JJ, van Overhagen H, et al. Hickman catheter-related infections in neutropenic patients: insertion in the operating theater versus insertion in the radiology suite. J Clin Oncol 1999;17:1304. https://doi.org/10.1200/JCO.1999.17.4.1304
  86. Howell PB, Walters PE, Donowitz GR, Farr BM. Risk factors for infection of adult patients with cancer who have tunnelled central venous catheters. Cancer 1995;75:1367-1375. https://doi.org/10.1002/1097-0142(19950315)75:6<1367::AID-CNCR2820750620>3.0.CO;2-Z
  87. Moreno A, Cervera C, Gavalda J, et al. Bloodstream infections among transplant recipients: results of a nationwide surveillance in Spain. Am J Transplant 2007;7:2579-2586. https://doi.org/10.1111/j.1600-6143.2007.01964.x
  88. Roder BL, Wandall DA, Frimodt-Moller N, Espersen F, Skinhoj P, Rosdahl VT. Clinical features of Staphylococcus aureus endocarditis: a 10-year experience in Denmark. Arch Intern Med 1999;159:462-469. https://doi.org/10.1001/archinte.159.5.462
  89. Chong YP, Park SJ, Kim HS, et al. Persistent Staphylococcus aureus bacteremia: a prospective analysis of risk factors, outcomes, and microbiologic and genotypic characteristics of isolates. Medicine (Baltimore) 2013;92:98-108. https://doi.org/10.1097/MD.0b013e318289ff1e
  90. Crowley AL, Peterson GE, Benjamin DK Jr, et al. Venous thrombosis in patients with short- and long-term central venous catheter-associated Staphylococcus aureus bacteremia. Crit Care Med 2008;36:385-390. https://doi.org/10.1097/01.CCM.0B013E3181611F914
  91. Park KH, Chong YP, Kim SH, et al. Clinical characteristics and therapeutic outcomes of hematogenous vertebral osteomyelitis caused by methicillin-resistant Staphylococcus aureus. J Infect 2013;67:556-564. https://doi.org/10.1016/j.jinf.2013.07.026
  92. Priest DH, Peacock JE Jr. Hematogenous vertebral osteomyelitis due to Staphylococcus aureus in the adult: clinical features and therapeutic outcomes. South Med J 2005;98:854-862. https://doi.org/10.1097/01.smj.0000168666.98129.33
  93. Vanholder R, Canaud B, Fluck R, et al. Catheter-related blood stream infections (CRBSI): a European view. Nephrol Dial Transplant 2010;25:1753-1756. https://doi.org/10.1093/ndt/gfq205
  94. Guembe M, Rodriguez-Creixems M, Martin-Rabadan P, Alcala L, Munoz P, Bouza E. The risk of catheter-related bloodstream infection after withdrawal of colonized catheters is low. Eur J Clin Microbiol Infect Dis 2013. doi:10.1007/s10096-013-2004-8.
  95. Timsit JF, Dubois Y, Minet C, et al. New challenges in the diagnosis, management, and prevention of central venous catheter-related infections. Semin Respir Crit Care Med 2011;32:139-150. https://doi.org/10.1055/s-0031-1275526
  96. Hetem DJ, de Ruiter SC, Buiting AG, et al. Preventing Staphylococcus aureus bacteremia and sepsis in patients with Staphylococcus aureus colonization of intravascular catheters: a retrospective multicenter study and meta-analysis. Medicine (Baltimore) 2011;90:284-288. https://doi.org/10.1097/MD.0b013e31822403e9
  97. Ekkelenkamp MB, van der Bruggen T, van de Vijver DA, Wolfs TF, Bonten MJ. Bacteremic complications of intravascular catheters colonized with Staphylococcus aureus. Clin Infect Dis 2008;46:114-118. https://doi.org/10.1086/524077
  98. Munoz P, Fernandez Cruz A, Usubillaga R, et al. Central venous catheter colonization with Staphylococcus aureus is not always an indication for antimicrobial therapy. Clin Microbiol Infect 2012;18:877-882. https://doi.org/10.1111/j.1469-0691.2011.03683.x
  99. Ruhe JJ, Menon A. Clinical significance of isolated Staphylococcus aureus central venous catheter tip cultures. Clin Microbiol Infect 2006;12:933-936. https://doi.org/10.1111/j.1469-0691.2006.01491.x
  100. Perez-Parra A, Munoz P, Guinea J, Martin-Rabadan P, Guembe M, Bouza E. Is Candida colonization of central vascular catheters in non-candidemic, non-neutropenic patients an indication for antifungals? Intensive Care Med 2009;35:707-712. https://doi.org/10.1007/s00134-009-1431-6
  101. Leenders NH, Oosterheert JJ, Ekkelenkamp MB, De Lange DW, Hoepelman AI, Peters EJ. Candidemic complications in patients with intravascular catheters colonized with Candida species: an indication for preemptive antifungal therapy? Int J Infect Dis 2011;15:e453-458. https://doi.org/10.1016/j.ijid.2011.03.009
  102. Park KH, Cho OH, Lee SO, et al. Development of subsequent bloodstream infection in patients with positive Hickman catheter blood cultures and negative peripheral blood cultures. Diagn Microbiol Infect Dis 2011;70:31-36. https://doi.org/10.1016/j.diagmicrobio.2010.12.007

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