The Korean Journal of Medicine

The Korean Association of Internal Medicine (대한내과학회)
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A Case of Malignant Transformation in a Congenital Cystic Adenomatoid Malformation

선천성 낭성 선종양 기형에서 발견된 악성 변화 1예

  • Choi, Jae Woo (Department of Internal Medicine, Chungnam National University School of Medicine) ;
  • Song, Seung Taek (Department of Internal Medicine, Chungnam National University School of Medicine) ;
  • Park, Yeon Hee (Department of Internal Medicine, Chungnam National University School of Medicine) ;
  • Park, Dong Il (Department of Internal Medicine, Chungnam National University School of Medicine) ;
  • Chung, Chae Uk (Department of Internal Medicine, Chungnam National University School of Medicine) ;
  • Lee, Choong Sik (Department of Pathology, Chungnam National University School of Medicine) ;
  • Jung, Sung Soo (Department of Internal Medicine, Chungnam National University School of Medicine)
  • 최재우 (충남대학교 의학전문대학원 내과학교실) ;
  • 송승택 (충남대학교 의학전문대학원 내과학교실) ;
  • 박연희 (충남대학교 의학전문대학원 내과학교실) ;
  • 박동일 (충남대학교 의학전문대학원 내과학교실) ;
  • 정재욱 (충남대학교 의학전문대학원 내과학교실) ;
  • 이충식 (충남대학교 의학전문대학원 병리학교실) ;
  • 정성수 (충남대학교 의학전문대학원 내과학교실)
  • Received : 2013.08.19
  • Accepted : 2013.10.16
  • Published : 2014.04.01
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Abstract

Congenital cystic adenomatoid malformation (CCAM) of the lung is a rare condition with the potential for malignant transformation. Several cases that presented with malignant changes have been reported worldwide. However, no report about a malignant transformation case in a CCAM in Korea has been published. We report the first patient who had a malignant change in a CCAM. A 32-year-old female underwent a bilobectomy for a cystic lung lesion that was a type 1 CCAM associated with malignant transformation. A biopsy specimen from the resected cystic lesion showed foci of adenocarcinoma.

폐에서 발생한 CCAM은 전형적으로 신생아에서 나타나는 드문 선천성 기형이다. 성인에서는 type I CCAM이 다른 호흡기 이상들과 관련하여 극히 드물게 보고되고 있다. 하지만 만성 기침과 같이 서서히 발생하는 증상들이 있거나 영상의학검사에서 낭종 병터가 있는 경우에는 악성 변형 가능성이 있는 선천성 이상 병터일 수 있기 때문에 추가적인 검사가 필요하다. 이러한 병터의 진단과 치료를 위해서 전산화 단층촬영과 수술적 생검이 고려되어야 한다. 저자들은 수술적 절제한 CCAM에서 국내 처음으로 악성 변형을 관찰하였기에 문헌고찰과 함께 보고하는 바이다.

Keywords

References

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