Korean Journal of Radiology

The Korean Society of Radiology (대한영상의학회)
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Effect of Imaging Time in the Magnetic Resonance Detection of Intracerebral Metastases Using Single Dose Gadobutrol

  • Jeon, Ji-Young (Department of Radiology, Konkuk University Medical Center, Konkuk University School of Medicine) ;
  • Choi, Jin Woo (Department of Radiology, Konkuk University Medical Center, Konkuk University School of Medicine) ;
  • Roh, Hong Gee (Department of Radiology, Konkuk University Medical Center, Konkuk University School of Medicine) ;
  • Moon, Won-Jin (Department of Radiology, Konkuk University Medical Center, Konkuk University School of Medicine)
  • Received : 2013.08.01
  • Accepted : 2013.09.06
  • Published : 2014.02.01
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Abstract

Objective: To compare the effect of imaging time delay on the MR detection of intracerebral metastases using single dose gadobutrol. Materials and Methods: Twenty-one patients with intracerebral metastases underwent contrast-enhanced MR with three-dimensional T1-weighted sequence at 1 minute, 5 minutes and 10 minutes after a single dose injection of gadobutrol. One hundred index metastatic lesions (1 to 30 mm; median, 7 mm) were chosen for the analysis. For the qualitative analysis, lesion conspicuity were assessed on a 1 (worst) to 5 (best) scale of the index lesions by an expert reader. For the quantitative analysis, signal intensity (SI) of enhancing lesions and normal parenchyma was measured to determine the contrast rate (CR, %) ([postcontrast $SI\;_{lesion}$ - postcontrast $SI\;_{white\;matter}$] ${\times}$ 100 / postcontrast $SI\;_{white\;matter}$) and the enhancement rate (ER, %) ([postcontrast $SI\;_{lesion}$ - baseline $SI\;_{gray\;matter}$] ${\times}$ 100 / baseline $SI\;_{gray\;matter}$). Statistical comparisons were made between three different time delays. Results: Lesion conspicuity did not differ significantly among the three time delays (p = 0.097). Although the SI, CR and ER of lesions did not reveal any significant difference between 1 minute and 5 minutes delayed images, both the 1 minute and 5 minutes delayed images showed significantly higher CRs of lesions compared with the 10 minutes delayed images (p = 0.004 and p = 0.001, respectively). Conclusion: With single dose gadobutrol, imaging time delay did not have an effect on lesion conspicuity. Both 1-minute and 5-minute-delayed imaging after gadobutrol injection appears to be effective for the detection of intracerebral metastases.

Keywords

Acknowledgement

Supported by : Konkuk University Medical Center

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