The Korean Journal of Medicine

The Korean Association of Internal Medicine (대한내과학회)
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Effective Treatment of Intractable Diarrhea Associated with Common Variable Immunodeficiency with Oral Budesonide

경구용 부데소나이드로 치료한 공통가변성 면역결핍증에서의 설사

  • Jeon, Ji Hyun (Department of Medicine, Dankook University College of Medicine) ;
  • Lim, Do Hyoung (Department of Medicine, Dankook University College of Medicine) ;
  • Park, Chang Hyun (Department of Medicine, Dankook University College of Medicine) ;
  • Kwon, Hyeok Chan (Department of Medicine, Dankook University College of Medicine) ;
  • Jung, Ji Yeon (Department of Medicine, Dankook University College of Medicine) ;
  • Park, Keon Woo (Department of Medicine, Dankook University College of Medicine) ;
  • Lee, Soon Il (Department of Medicine, Dankook University College of Medicine)
  • 전지현 (단국대학교 의과대학 내과학교실) ;
  • 임도형 (단국대학교 의과대학 내과학교실) ;
  • 박창현 (단국대학교 의과대학 내과학교실) ;
  • 권혁찬 (단국대학교 의과대학 내과학교실) ;
  • 정지연 (단국대학교 의과대학 내과학교실) ;
  • 박건우 (단국대학교 의과대학 내과학교실) ;
  • 이순일 (단국대학교 의과대학 내과학교실)
  • Received : 2013.07.15
  • Accepted : 2013.09.09
  • Published : 2014.05.01
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Abstract

Common variable immunodeficiency (CVID) is the most common symptomatic primary antibody deficiency syndrome and has a high prevalence of gastrointestinal complications. We report the case of a 36-year-old male with CVID who presented with chronic intractable diarrhea and malabsorption. A comprehensive evaluation revealed no secondary causes of his symptoms. He was treated symptomatically without improvement. After receiving systemic steroid treatment, his symptoms improved, but returned soon after tapering the steroid. When he was subsequently administered oral budesonide, his symptoms and quality of life improved; this effect lasted for 20 months without unacceptable side effects.

공통 가변성 면역결핍증은 가장 흔한 일차성 항체 결핍 증후군의 하나로 많은 환자에서 위장관 증상이 동반된다. 현재까지 전신 스테로이드 치료가 효과적인 것으로 알려졌으나 전신 부작용으로 그 사용이 제한적이다. 경구용 부데소나이드 치료는 전신 부작용 없이 공통 가변성 면역결핍증의 위장관 증상 개선에 효과적인 약물이다.

Keywords

References

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