Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Use of Synthetic Bone Material with Osteoinductive Proteins to Promote Bone Healing in Dogs

개에서 골형성 촉진을 위한 합성 골물질과 골유도 단백질의 사용

  • Accepted : 2014.09.29
  • Published : 2014.10.31
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Abstract

Bone grafts are essential for promoting bone healing in some orthopedic cases, and synthetic bone materials have been widely used for bone defects. In addition, osteoinductive proteins such as bone morphogenetic protein and fibroblast growth factor promote osteoblast differentiation and proliferation. The combination of these factors is very useful clinically for promoting bone healing. In this study, we report the use of synthetic bone materials and osteoinductive proteins to repair bone defects in two dogs.

몇몇의 정형외과 질환에서 골이식은 필수적이며, 합성 골물질은 골이식물로서 널리 쓰여지고 있다. 한편, 골형성 단백질과 섬유아세포 성장 인자와 같은 골 유도 단백질은 골아세포의 분화 및 증식을 촉진시킬 수 있다. 이러한 물질들의 조합은 조기에 골형성을 촉진시킬 수 있어 수의임상에서 널리 사용되고 있다. 이번 증례보고에서는 합성 골물질과 골유도 단백질을 조합하여 대형 골결손부를 성공적으로 치료한 개의 2 증례를 보고하고자 한다.

Keywords

References

  1. Basilico C, Moscatelli D. The fgf family of growth factors and oncogenes. Adv Cancer Res 1992; 59: 115-165. https://doi.org/10.1016/S0065-230X(08)60305-X
  2. Choi S, Lee J, Igawa K, Liu IL, Honnami M, Suzuki S, Nishimura R, Chung UI, Sasaki N, Mochizuki M. Changes in bone regeneration by trehalose coating and basic fibroblast growth factor after implantation of tailor-made bone implants in dogs. J Vet Med Sci 2013; 75: 721-726. https://doi.org/10.1292/jvms.12-0244
  3. Choi S, Lee J, Igawa K, Suzuki S, Mochizuki M, Nishimura R, Chung UI, Sasaki N. Effect of trehalose coating on basic fibroblast growth factor release from tailor-made bone implants. J Vet Med Sci 2011; 73: 1547-1552. https://doi.org/10.1292/jvms.11-0016
  4. Flatley TJ, Lynch KL, Benson M. Tissue response to implants of calcium phosphate ceramic in the rabbit spine. Clin Orthop Relat Res 1983; 246-252.
  5. Flautre B, Descamps M, Delecourt C, Blary MC, Hardouin P. Porous ha ceramic for bone replacement: Role of the pores and interconnections - experimental study in the rabbit. J Mater Sci Mater Med 2001; 12: 679-682. https://doi.org/10.1023/A:1011256107282
  6. Itoh T, Mochizuki M, Fuda K, Nishimura R, Matsunaga S, Kadosawa T, Sasaki N. Femoral nonunion fracture treated with recombinant human bone morphogenetic protein-2 in a dog. J Vet Med Sci 1998; 60: 535-538. https://doi.org/10.1292/jvms.60.535
  7. Kawaguchi H, Kurokawa T, Hanada K, Hiyama Y, Tamura M, Ogata E, Matsumoto T. Stimulation of fracture repair by recombinant human basic fibroblast growth factor in normal and streptozotocin-diabetic rats. Endocrinology 1994; 135: 774-781. https://doi.org/10.1210/endo.135.2.8033826
  8. Kuhne JH, Bartl R, Frisch B, Hammer C, Jansson V, Zimmer M. Bone formation in coralline hydroxyapatite. Effects of pore size studied in rabbits. Acta Orthop Scand 1994; 65: 246-252. https://doi.org/10.3109/17453679408995448
  9. Lee SC, Shea M, Battle MA, Kozitza K, Ron E, Turek T, Schaub RG, Hayes WC. Healing of large segmental defects in rat femurs is aided by rhbmp-2 in plga matrix. J Biomed Mater Res 1994; 28: 1149-1156. https://doi.org/10.1002/jbm.820281005
  10. Marie PJ. Fibroblast growth factor signaling controlling osteoblast differentiation. Gene 2003; 316: 23-32. https://doi.org/10.1016/S0378-1119(03)00748-0
  11. Millis D, Jackson A. Delayed unions, nonunions and malunions. In: Textbook of small animal surgery, Philadelphia: Saunders. 2003: 1849-1861.
  12. Milovancev M, Muir P, Manley PA, Seeherman HJ, Schaefer S. Clinical application of recombinant human bone morphogenetic protein-2 in 4 dogs. Vet Surg 2007; 36: 132-140. https://doi.org/10.1111/j.1532-950X.2007.00245.x
  13. Nair MB, Varma H, Shenoy SJ, John A. The treatment of goat femur segmental defects with silica coated hydroxyapatite - one year follow up. Tissue Eng Part A 2009.
  14. Naski MC, Ornitz DM. Fgf signaling in skeletal development. Front Biosci 1998; 3: d781-794. https://doi.org/10.2741/A321
  15. Por YC, Barcelo CR, Salyer KE, Genecov DG, Troxel K, Gendler E, Elsalanty ME, Opperman LA. Bone generation in the reconstruction of a critical size calvarial defect in an experimental model. J Craniofac Surg 2008; 19: 383-392. https://doi.org/10.1097/SCS.0b013e318163e415
  16. Spector DI, Keating JH, Boudrieau RJ. Immediate mandibular reconstruction of a 5 cm defect using rhbmp-2 after partial mandibulectomy in a dog. Vet Surg 2007; 36: 752-759. https://doi.org/10.1111/j.1532-950X.2007.00332.x
  17. Trombelli L, Heitz-Mayfield LJ, Needleman I, Moles D, Scabbia A. A systematic review of graft materials and biological agents for periodontal intraosseous defects. J Clin Periodontol 2002; 29(Suppl 3): 117-135. https://doi.org/10.1034/j.1600-051X.29.s3.7.x
  18. Wang JS, Aspenberg P. Basic fibroblast growth factor enhances bone-graft incorporation: Dose and time dependence in rats. J Orthop Res 1996; 14: 316-323. https://doi.org/10.1002/jor.1100140222