Genomics & Informatics

Korea Genome Organization (한국유전체학회)
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Genome-Wide Association Study of Medication Adherence in Chronic Diseases in the Korean Population

  • Seo, Incheol (Department of Microbiology, Keimyung University School of Medicine) ;
  • Suh, Seong-Il (Department of Microbiology, Keimyung University School of Medicine) ;
  • Suh, Min-Ho (Department of Microbiology, Keimyung University School of Medicine) ;
  • Baek, Won-Ki (Department of Microbiology, Keimyung University School of Medicine)
  • Received : 2014.06.30
  • Accepted : 2014.07.20
  • Published : 2014.09.30
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Abstract

Medication adherence is generally defined as the extent of voluntary cooperation of a patient in taking medicine as prescribed. Adherence to long-term treatment with chronic disease is essential for reducing disease comorbidity and mortality. However, medication non-adherence in chronic disease averages 50%. This study was conducted a genome-wide association study to identify the genetic basis of medication adherence. A total of 235 medication non-adherents and 1,067 medication adherents with hypertension or diabetes were used from the Korean Association Resource project data according to the self-reported treatment status of each chronic disease, respectively. We identified four single nucleotide polymorphisms with suggestive genome-wide association. The most significant single nucleotide polymorphism was rs6978712 (chromosome 7, $p=4.87{\times}10^{-7}$), which is located proximal to the GCC1 gene, which was previously implicated in decision-making capability in drug abusers. Two suggestive single nucleotide polymorphisms were in strong linkage disequilibrium ($r^2$ > 0.8) with rs6978712. Thus, in the aspect of decision-making in adherence behavior, the association between medication adherence and three loci proximal to the GCC1 gene seems worthy of further research. However, to overcome a few limitations in this study, defining the standardized phenotype criteria for self-reported adherence should be performed before replicating association studies.

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