The Korean journal of internal medicine

The Korean Association of Internal Medicine (대한내과학회)
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Prediction of infarct severity from triiodothyronine levels in patients with ST-elevation myocardial infarction

  • Kim, Dong Hun (Department of Radiology, Chosun University School of Medicine) ;
  • Choi, Dong-Hyun (Department of Internal Medicine, Chosun University School of Medicine) ;
  • Kim, Hyun-Wook (Department of Internal Medicine, Chosun University School of Medicine) ;
  • Choi, Seo-Won (Department of Internal Medicine, Chosun University School of Medicine) ;
  • Kim, Bo-Bae (Department of Internal Medicine, Chosun University School of Medicine) ;
  • Chung, Joong-Wha (Department of Internal Medicine, Chosun University School of Medicine) ;
  • Koh, Young-Youp (Department of Internal Medicine, Chosun University School of Medicine) ;
  • Chang, Kyong-Sig (Department of Internal Medicine, Chosun University School of Medicine) ;
  • Hong, Soon-Pyo (Department of Internal Medicine, Chosun University School of Medicine)
  • Received : 2013.04.24
  • Accepted : 2013.10.28
  • Published : 2014.07.01
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Abstract

Background/Aims: The aim of the present study was to evaluate the relationship between thyroid hormone levels and infarct severity in patients with ST-elevation myocardial infarction (STEMI). Methods: We retrospectively reviewed thyroid hormone levels, infarct severity, and the extent of transmurality in 40 STEMI patients evaluated via contrast-enhanced cardiac magnetic resonance imaging. Results: The high triiodothyronine ($T_3$) group (${\geq}68.3ng/dL$) exhibited a significantly higher extent of transmural involvement (late transmural enhancement > 75% after administration of gadolinium contrast agent) than did the low $T_3$ group (60% vs. 15%; p = 0.003). However, no significant difference was evident between the high- and low-thyroid-stimulating hormone/free thyroxine ($FT_4$) groups. When the $T_3$ cutoff level was set to 68.3 ng/dL using a receiver operating characteristic curve, the sensitivity was 80% and the specificity 68% in terms of differentiating between those with and without transmural involvement. Upon logistic regression analysis, high $T_3$ level was an independent predictor of transmural involvement after adjustment for the presence of diabetes mellitus (DM) and the use of glycoprotein IIb/IIIa inhibitors (odds ratio, 40.62; 95% confidence interval, 3.29 to 502; p = 0.004). Conclusions: The $T_3$ level predicted transmural involvement that was independent of glycoprotein IIb/IIIa inhibitor use and DM positivity.

Keywords

References

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