Annals of Laboratory Medicine

Korean Society for Laboratory Medicine (대한진단검사의학회)
권호 표지
DOI QR코드

DOI QR Code

False-Positive Reactions Against HLA Class II Molecules Detected in Luminex Single-Antigen Bead Assays

  • In, Ji Won (Department of Laboratory Medicine, Seoul National University College of Medicine) ;
  • Rho, Eun Youn (Department of Laboratory Medicine, Seoul National University College of Medicine) ;
  • Shin, Sue (Department of Laboratory Medicine, Seoul National University College of Medicine) ;
  • Park, Kyoung Un (Department of Laboratory Medicine, Seoul National University College of Medicine) ;
  • Song, Eun Young (Department of Laboratory Medicine, Seoul National University College of Medicine)
  • Received : 2014.03.03
  • Accepted : 2014.07.23
  • Published : 2014.09.01
⟨ Previous Next ⟩

Abstract

Keywords

References

  1. Mohan S, Palanisamy A, Tsapepas D, Tanriover B, Crew RJ, Dube G, et al. Donor-specific antibodies adversely affect kidney allograft outcomes. J Am Soc Nephrol 2012;23:2061-71. https://doi.org/10.1681/ASN.2012070664
  2. Loupy A, Hill GS, Jordan SC. The impact of donor-specific anti-HLA antibodies on late kidney allograft failure. Nat Rev Nephrol 2012;8:348-57. https://doi.org/10.1038/nrneph.2012.81
  3. Zachary AA and Leffell MS. Detecting and monitoring human leukocyte antigen-specific antibodies. Hum Immunol 2008;69:591-604. https://doi.org/10.1016/j.humimm.2008.06.013
  4. Pereira S, Perkins S, Lee JH, Shumway W, LeFor W, Lopez-Cepero M, et al. Donor-specific antibody against denatured HLA-A1: clinically nonsignificant? Hum Immunol 2011;72:492-8. https://doi.org/10.1016/j.humimm.2011.02.012
  5. Poli F, Benazzi E, Innocente A, Nocco A, Cagni N, Gianatti A, et al. Heart transplantation with donor-specific antibodies directed toward denatured HLA-A*02:01: a case report. Hum Immunol 2011;72:1045-8. https://doi.org/10.1016/j.humimm.2011.08.001
  6. Grenzi PC, de Marco R, Silva RZ, Campos EF, Gerbase-DeLima M. Antibodies against denatured HLA class II molecules detected in luminex-single antigen assay. Hum Immunol 2013;74:1300-3. https://doi.org/10.1016/j.humimm.2013.06.035
  7. Jacob EK, De Goey SR, Gandhi MJ. Positive virtual crossmatch with negative flow crossmatch results in two cases. Transpl Immunol 2011; 25:77-81. https://doi.org/10.1016/j.trim.2011.05.007
  8. El-Awar N, Terasaki PI, Nguyen A, Sasaki N, Morales-Buenrostro LE, Saji H, et al. Epitopes of human leukocyte antigen class I antibodies found in sera of normal healthy males and cord blood. Hum Immunol 2009;70:844-53. https://doi.org/10.1016/j.humimm.2009.06.020
  9. Zoet YM, Brand-Schaaf SH, Roelen DL, Mulder A, Claas FH, Doxiadis II. Challenging the golden standard in defining donor-specific antibodies: does the solid phase assay meet the expectations? Tissue Antigens 2011;77:225-8. https://doi.org/10.1111/j.1399-0039.2010.01608.x
  10. Kim SY, Han BY, Hyun J,Joo SY, Song EY, Park MH. Evaluation of flow cytometric crossmatch results in comparison with donor-specific antibodies detected by Luminex-PRA tests in organ transplantation patients. J Korean Soc Transplant 2012;26:92-100. https://doi.org/10.4285/jkstn.2012.26.2.92
  11. Ravindranath MH, Kaneku H, El-Awar N, Morales-Buenrostro LE, Terasaki PI. Antibodies to HLA-E in nonalloimmunized males: pattern of HLA-Ia reactivity of anti-HLA-E-positive sera. J Immunol 2010;185: 1935-48. https://doi.org/10.4049/jimmunol.1000424

Cited by

  1. Alloantibody Generation and Effector Function Following Sensitization to Human Leukocyte Antigen vol.7, pp.None, 2016, https://doi.org/10.3389/fimmu.2016.00030
  2. Technical Limitations of the C1q Single-Antigen Bead Assay to Detect Complement Binding HLA-Specific Antibodies vol.101, pp.6, 2017, https://doi.org/10.1097/tp.0000000000001270