Annals of Laboratory Medicine

Korean Society for Laboratory Medicine (대한진단검사의학회)
권호 표지
DOI QR코드

DOI QR Code

Absence of $HLA-B^*1502$ and $HLA-A^*3101$ Alleles in 9 Korean Patients With Antiepileptic Drug-Induced Skin Rash: A Preliminary Study

  • Song, Ju Sun (Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Kang, Eun-Suk (Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Joo, Eun Yeon (Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Hong, Seung Bong (Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Seo, Dae-Won (Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Lee, Soo-Youn (Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine)
  • Received : 2014.03.06
  • Accepted : 2014.07.23
  • Published : 2014.09.01
⟨ Previous Next ⟩

Abstract

There have been a number of studies about correlations between HLA genotypes in various ethnic groups and occurrence of various cutaneous adverse drug reactions, ranging in intensity from mild to severe, caused by antiepileptic drugs (AEDs). This is the first report analyzing the HLA genotypes of 9 Korean patients with skin rashes induced by various AEDs. The AEDs that induced skin rash were lamotrigine (n=3), carbamazepine (n=3), oxcarbazepine (n=1), phenobarbital (n=1), and phenytoin (n=1). None of the patients' HLA genotypes was either $HLA-B^*1502$ or $HLA-A^*3101$. Based on these series of cases, AED-induced skin rash can occur independently of $HLA-B^*1502$ or $HLA-A^*3101$ genotypes in the Korean patients.

Keywords

Acknowledgement

Supported by : Samsung Biomedical Research Institute

References

  1. Chung WH, Hung SI, Chen YT. Genetic predisposition of life-threatening antiepileptic-induced skin reactions. Expert Opin Drug Saf 2010;9:15-21. https://doi.org/10.1517/14740330903427969
  2. Chong KW, Chan DW, Cheung YB, Ching LK, Hie SL, Thomas T, et al. Association of carbamazepine-induced severe cutaneous drug reactions and HLA-B*1502 allele status, and dose and treatment duration in paediatric neurology patients in Singapore. Arch Dis Child 2014;99: 581-4. https://doi.org/10.1136/archdischild-2013-304767
  3. Kim SH, Lee KW, Song WJ, Kim SH, Jee YK, Lee SM, et al. Carbamazepine-induced severe cutaneous adverse reactions and HLA genotypes in Koreans. Epilepsy Res 2011;97:190-7. https://doi.org/10.1016/j.eplepsyres.2011.08.010
  4. Kaniwa N, Saito Y,Aihara M, Matsunaga K, Tohkin M, Kurose K, et al. HLA-B*1511 is a risk factor for carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese patients. Epilepsia 2010;51:2461-5. https://doi.org/10.1111/j.1528-1167.2010.02766.x
  5. McCormack M, Alfirevic A, Bourgeois S, Farrell JJ, Kasperavičiūtė D, Carrington M, et al. HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans. N Engl J Med 2011;364:1134-43. https://doi.org/10.1056/NEJMoa1013297
  6. Ozeki T, Mushiroda T, Yowang A, Takahashi A, Kubo M, Shirakata Y, et al. Genome-wide association study identifies HLA-A*3101 allele as a genetic risk factor for carbamazepine-induced cutaneous adverse drug reactions in Japanese population. Hum Mol Genet 2011;20:1034-41. https://doi.org/10.1093/hmg/ddq537
  7. Wang XQ, Lang SY, Shi XB, Tian HJ, Wang RF, Yang F. Cross-reactivity of skin rashes with current antiepileptic drugs in Chinese population. Seizure 2010;19:562-6. https://doi.org/10.1016/j.seizure.2010.09.003
  8. Zaccara G, Franciotta D, Perucca E. Idiosyncratic adverse reactions to antiepileptic drugs. Epilepsia 2007;48:1223-44. https://doi.org/10.1111/j.1528-1167.2007.01041.x
  9. Hu FY, Wu XT, An DM, Yan B, Stefan H, Zhou D. Pilot association study of oxcarbazepine-induced mild cutaneous adverse reactions with HLA-B*1502 allele in Chinese Han population. Seizure 2011;20:160-2. https://doi.org/10.1016/j.seizure.2010.11.014
  10. Shi YW, Min FL, Liu XR, Zan LX, Gao MM, Yu MJ, et al. Hla-B alleles and lamotrigine-induced cutaneous adverse drug reactions in the Han Chinese population. Basic Clin Pharmacol Toxicol 2011;109:42-6. https://doi.org/10.1111/j.1742-7843.2011.00681.x
  11. Gogtay NJ, Bavdekar SB, Kshirsagar NA. Anticonvulsant hypersensitivity syndrome: a review. Expert Opin Drug Saf 2005;4:571-81. https://doi.org/10.1517/14740338.4.3.571
  12. Lee KW and Park MH. [New HLA nomenclature (2010) and its clinical application in Koreans]. Korean J Lab Med 2010;30:203-17. https://doi.org/10.3343/kjlm.2010.30.3.203
  13. Hung SI, Chung WH, Jee SH, Chen WC, Chang YT, Lee WR, et al. Genetic susceptibility to carbamazepine-induced cutaneous adverse drug reactions. Pharmacogenet Genomics 2006;16:297-306. https://doi.org/10.1097/01.fpc.0000199500.46842.4a
  14. Aihara M. Pharmacogenetics of cutaneous adverse drug reactions. J Dermatol 2011;38:246-54. https://doi.org/10.1111/j.1346-8138.2010.01196.x
  15. Hung SI, Chung WH, Liu ZS, Chen CH, Hsih MS, Hui RC, et al. Common risk allele in aromatic antiepileptic-drug induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Han Chinese. Pharmacogenomics 2010;11:349-56. https://doi.org/10.2217/pgs.09.162
  16. Lee KW, Oh DH, Lee C, Yang SY.Allelic and haplotypic diversity of HLA-A, -B, -C, -DRB1, and -DQB1 genes in the Korean population. Tissue Antigens 2005;65:437-47. https://doi.org/10.1111/j.1399-0039.2005.00386.x
  17. Burtis C, Ashwood E, Bruns D, eds. Tietz Textbook of clinical chemistry and molecular diagnostics, 5th ed. St. Louis, MO: Elsevier, 2012.
  18. Lonjou C, Thomas L, Borot N, Ledger N, de Toma C, LeLouet H, et al. A marker for Stevens-Johnson syndrome ...: ethnicity matters. Pharmacogenomics J 2006;6:265-8. https://doi.org/10.1038/sj.tpj.6500356

Cited by

  1. HLA-A*24:02/B*51:01haplotype and lamotrigine-induced cutaneous adverse drug reactions in Koreans vol.24, pp.3, 2016, https://doi.org/10.12793/tcp.2016.24.3.143
  2. HLA-B*5701 and HLA-B*5801 in an Indian patient with anti-epileptics induced cutaneous adverse drug reactions vol.75, pp.4, 2014, https://doi.org/10.1007/s00228-018-02618-5