Current Research on Agriculture and Life Sciences
- 제32권3호
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- Pages.145-148
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- 2014
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- 2287-271X(pISSN)
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- 2288-0356(eISSN)
DOI QR Code
Assessment of Skin Irritation Caused by S-(-)-10,11-Dihydroxyfarnesoic Acid Methyl Ester, a Metabolite of Beauveria bassiana CS1029
- Kim, Min-A (Department of Food Science & Biotechnology, Kyungpook National University) ;
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Lee, Sang-Han
(Department of Food Science & Biotechnology, Kyungpook National University)
- 투고 : 2014.08.20
- 심사 : 2014.09.26
- 발행 : 2014.09.30
초록
To determine whether S-(-)-10,11-dihydroxyfarnesic acid methyl ester (DHFAME) produced by Beauveria bassiana CS1029 potentially causes acute skin irritation as a cosmetic ingredient, a skin toxicity test was conducted as recommended for compliance with Korea Food and Drug Administration regulations. New Zealand White rabbits were treated with 100 mg/dose of DHFAME according to standard guidelines. No significant skin lesions or inflammation was observed in the DHFAME-treated group. Furthermore, DHFAME did not appear to cause skin irritation, as assessed by clinical observation of the rabbits. Thus, when taken together, the present results suggest that DHFAME is a promising potential cosmetic ingredient that does not irritate the skin.