Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Compounds from the Aerial Parts of Aceriphyllum rossii and Their Cytotoxic Activity

  • Received : 2013.12.31
  • Accepted : 2014.01.27
  • Published : 2014.09.30
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Abstract

The purification of the MeOH extracts from the aerial parts of Aceriphyllum rossii Engler (Saxifragaceae) using column chromatography furnished fourteen compounds (1 - 14). The chemical structures of the isolated compounds were determined using mainly nuclear magnetic resonance spectra and mass spectrometry. All the isolated compounds were tested for their cytotoxic activity against LH-60, MCF-7 and HeLa cancer cells in vitro using a MTT assay method. Compounds possessing an olean-triterpenoid skeleton entirely exhibit dose dependent cytotoxic activity. These findings partially confirmed the anticancer effect of this medicinal plant, suggesting a further study on the anticancer potential of the triterpenoid structure in compounds from this plant.

Keywords

References

  1. Kim Van, L. T.; Tran M . H.; Phuong T. T.; Tran M. N.; Kim, J. C.; Jang, H. S; Cai, X. F.; Oh, S. R.; Min, B. S.; Woo, M. H.; Choi, J. S.; Lee, H. K.; Bea, K. H. J. Nat. Prod. 2009, 72, 1419-1423. https://doi.org/10.1021/np900273z
  2. Lee, I. S.; Yoo, J. K.; Na, M. K.; Min, B. S.; Lee, J. P.; Yun, B. S.; Jin, W. Y.; Kim, H. J.; Youn, U. J.; Chen, Q. C.; Song, K. S.; Seong, Y. H.; Bea, K. H. Chem. Pharm. Bull. 2007, 55, 1376-1378. https://doi.org/10.1248/cpb.55.1376
  3. Han, J. T.; Kim, H. Y.; Park, Y. D.; Lee, Y. H.; Lee, K. R.; Kwon, B. M.; Baek, N. I.; Planta Med. 2002, 68, 558-561. https://doi.org/10.1055/s-2002-32565
  4. Zheng, C. J.; Sohn, M. J.; Kim, K. Y.; Yu, H. E.; Kim, W. G. J. Agric. Food Chem. 2008, 56, 11752-11756. https://doi.org/10.1021/jf802832w
  5. Min, B. S.; Lee, I.; Chang, M. J.; Yoo, J. K.; Na, M.; Hung, T. M.; Thuong, P. T.; Lee, J.; Kim, J. H.; Kim, J. C.; Woo, M. H.; Choi, J. S.; Lee, H. K.; Bae, K. Planta Med. 2008, 74, 726-729. https://doi.org/10.1055/s-2008-1074534
  6. Min, B. S. Arch. Pharm. Res. 2012, 35, 1003-1008. https://doi.org/10.1007/s12272-012-0607-8
  7. Cui, L.; Li, Z.; Sun, Y. N.; Zhang, N.; Kim Y. H. J. Chin. Pharm. Sci. 2012, 21, 178-182.
  8. Han, J. T.; Bang, M. H.; Chun, O. K.; Kim, D. O.; Lee, C. Y.; Baek, N. I. Arch. Pharm. Res. 2004, 27, 390-395. https://doi.org/10.1007/BF02980079
  9. Trang, T. T. T.; To D. C.; Tran M. H.; Kim, J. A.; Lee, J. H.; Woo, M. H.; Choi, J. S.; Lee, H. K.; Min, B. S. Chem. Pharm. Bull. 2014, 62, 185-190. https://doi.org/10.1248/cpb.c13-00664
  10. Otsuka, H. Phytochemistry 1994, 37, 461-465. https://doi.org/10.1016/0031-9422(94)85080-1
  11. Rimando, A. M.; Pezzuto, J. M.; Farnsworth, N. R.; Santisuk, T.; Reutrakul, V.; Kawanishi, K. J. Nat. Prod. 1994, 57, 896-904. https://doi.org/10.1021/np50109a004
  12. Na, M. K.; Cui, L.; Min, B. S.; Bae, K. H.; Yoo, J. K.; Kim, B. Y.; Oh, W. K.; Ahn, J. S. Bioorg. Med. Chem. Lett. 2006, 16, 3273-3276. https://doi.org/10.1016/j.bmcl.2006.03.036
  13. Thao, N. T. P.; Hung, T. M.; Lee, M. K.; Kim, J. C.; Min, B. S.; Bae, K. H. Chem. Pharm. Bull. 2010, 58, 121-124. https://doi.org/10.1248/cpb.58.121
  14. Yoshida, T.; Hatano, T.; Okuda, T.; Memon, M. U.; Shingu, T.; Inoue, K. Chem. Pharm. Bull. 1984, 32, 1790-1799. https://doi.org/10.1248/cpb.32.1790
  15. Ryu, H. G.; Jeong, S. J.; Kwon, H. Y.; Lee, H. J.; Lee, E. O.; Lee, M. H.; Choi, S. H.; Ahn, K. S.; Kim, S. H. Toxicol. In Vitro 2012, 26, 206-214. https://doi.org/10.1016/j.tiv.2011.11.012
  16. Oh, G. S.; Pae, H. O.; Oh, H.; Hong, S. G.; Kim, I. K.; Chai, K. Y.; Yun, Y. G.; Kwon, T. O.; Chung, H. T. Cancer Lett. 2001, 174, 17-24. https://doi.org/10.1016/S0304-3835(01)00680-2
  17. Yang, M. H.; Vasquez, Y.; Ali, Z.; Khan, I. A.; Khan, S. I. J. Ethnopharmacol. 2013, 149, 490-498. https://doi.org/10.1016/j.jep.2013.07.003
  18. Won, S. J.; Ki, Y. S.; Chung, K. S.; Choi, J. H.; Bae, K. H.; Lee, K. T. Biol. Pharm. Bull. 2010, 33, 1620-1626. https://doi.org/10.1248/bpb.33.1620
  19. Kim, S. S.; Won, S. J.; Kim, N. J.; Yoo, J. K.; Bae, K.; Lee, K. T. Biol. Pharm. Bull. 2009, 32, 91-98. https://doi.org/10.1248/bpb.32.91