Clinical and Experimental Reproductive Medicine

The Korean Society for Reproductive Medicine (대한생식의학회)
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Platelet volume indices in patients with varicocele

  • Mahdavi-Zafarghandi, Reza (Department of Urology, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences) ;
  • Shakiba, Behnam (Department of Urology, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences) ;
  • Keramati, Mohammad Reza (Cancer Molecular Pathology Research Center, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences) ;
  • Tavakkoli, Mahmoud (Department of Urology, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences)
  • Received : 2014.02.16
  • Accepted : 2014.05.09
  • Published : 2014.06.30
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Abstract

Objective: This study sought to evaluate platelet volume indices (mean platelet volume [MPV], platelet distribution width [PDW], and platelet large cell ratio [P-LCR]) in varicocele patients, and compare it with platelet volume parameters in healthy controls. Methods: This cross-sectional study involved 2 groups: group 1 included 51 varicocele subjects and group 2 consisted of 50 healthy control subjects of similar ages. Peripheral venous blood samples were collected with ethylenediaminetetraacetic acid-K2 anticoagulant between 8:30 AM and 10 AM following an overnight fast. Platelet volume parameters (MPV, PDW, and P-LCR) were measured in both groups within 2 hours of sampling. Results: The mean PDW, MPV, and P-LCR were $13.9{\pm}2.5%$, $10.1{\pm}1.3fL$, and $27.3{\pm}7.8%$ in varicocele patients, respectively, and were $12.6{\pm}2.4%$, $9.3{\pm}1.1fL$, and $21.9{\pm}6.4%$ in the control group, respectively. The mean PDW, MPV, and P-LCR were significantly higher in the varicocele group than the control group. Conclusion: The results of the present study suggest that vascular components may play an important role in the pathophysiology of varicocele; therefore, there is a great need for prospective studies to confirm this relationship.

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References

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