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Pulmonary Toxocariasis Mimicking Invasive Aspergillosis in a Patient with Ulcerative Colitis

  • Park, Eun Jin (Department of Internal Medicine, Korea University College of Medicine) ;
  • Song, Joon Young (Department of Internal Medicine, Korea University College of Medicine) ;
  • Choi, Min Ju (Department of Internal Medicine, Korea University College of Medicine) ;
  • Jeon, Ji Ho (Department of Internal Medicine, Korea University College of Medicine) ;
  • Choi, Jah-Yeon (Department of Internal Medicine, Korea University College of Medicine) ;
  • Yang, Tae Un (Department of Internal Medicine, Korea University College of Medicine) ;
  • Hong, Kyung Wook (Department of Internal Medicine, Korea University College of Medicine) ;
  • Noh, Ji Yun (Department of Internal Medicine, Korea University College of Medicine) ;
  • Cheong, Hee Jin (Department of Internal Medicine, Korea University College of Medicine) ;
  • Kim, Woo Joo (Department of Internal Medicine, Korea University College of Medicine)
  • Received : 2014.03.19
  • Accepted : 2014.06.24
  • Published : 2014.08.31

Abstract

A 45-year-old-male who had underlying ulcerative colitis and presented with fever and dry cough. Initially, the patient was considered to have invasive aspergillosis due to a positive galactomannan assay. He was treated with amphotericin B followed by voriconazole. Nevertheless, the patient deteriorated clinically and radiographically. The lung biopsy revealed eosinophilic pneumonia, and ELISA for Toxocara antigen was positive, leading to a diagnosis of pulmonary toxocariasis. After a 10-day treatment course with albendazole and adjunctive steroids, the patient recovered completely without any sequelae. Pulmonary toxocariasis may be considered in patients with subacute or chronic pneumonia unresponsive to antibiotic agents, particularly in cases with eosinophilia.

Keywords

References

  1. Despommier D. Toxocariasis: clinical aspects, epidemiology, medical ecology, and molecular aspects. Clin Microbiol Rev 2003; 16: 265-272. https://doi.org/10.1128/CMR.16.2.265-272.2003
  2. Magnaval JF, Glickman LT, Dorchies P, Morassin B. Highlights of human toxocariasis. Korean J Parasitol 2001; 39: 1-11. https://doi.org/10.3347/kjp.2001.39.1.1
  3. Yoshikawa M, Koyama N, Hontsu S, Yamamoto Y, Mikasa K, Kimura H. Lessons from eight cases of adult pulmonary toxocariasis: abridged republication. Respirology 2011; 16: 1014-1015. https://doi.org/10.1111/j.1440-1843.2011.02000.x
  4. Rubinsky-Elefant G, Hirata CE, Yamamoto JH, Ferreira MU. Human toxocariasis: diagnosis, worldwide seroprevalences and clinical expression of the systemic and ocular forms. Ann Trop Med Parasitol 2010; 104: 3-23. https://doi.org/10.1179/136485910X12607012373957
  5. Yoon YS, Lee CH, Kang YA, Kwon SY, Yoon HI, Lee JH, Lee CT. Impact of toxocariasis in patients with unexplained patchy pulmonary infiltrate in Korea. J Korean Med Sci 2009; 24: 40-45. https://doi.org/10.3346/jkms.2009.24.1.40
  6. Pawlowski Z. Toxocariasis in humans: clinical expression and treatment dilemma. J Helminthol 2001; 75: 299-305. https://doi.org/10.1017/S0022149X01000464
  7. Abdi J, Darabi M, Sayehmiri K. Epidemiological situation of toxocariasis in Iran: meta-analysis and systematic review. Pak J Biol Sci 2012; 15: 1052-1055. https://doi.org/10.3923/pjbs.2012.1052.1055
  8. Fan CK, Hung CC, Du WY, Liao CW, Su KE. Seroepidemiology of Toxocara canis infection among mountain aboriginal schoolchildren living in contaminated districts in eastern Taiwan. Trop Med Int Health 2004; 9: 1312-1318. https://doi.org/10.1111/j.1365-3156.2004.01332.x
  9. Park HY, Lee SU, Huh S, Kong Y, Magnaval JF. A seroepidemiological survey for toxocariasis in apparently healthy residents in Gangwon-do, Korea. Korean J Parasitol 2002; 40: 113-117. https://doi.org/10.3347/kjp.2002.40.3.113
  10. Kim YJ, Kyung SY, An CH, Lim YH, Park JW, Jeong SH, Lee SP, Choi DC, Jeong YB, Kang SY. The characteristics of eosinophilc lung diseases cause by Toxocara canis larval infestation. Tuberc Respir Dis 2007; 62: 19-26. https://doi.org/10.4046/trd.2007.62.1.19
  11. Inoue K, Inoue Y, Arai T, Nawa Y, Kashiwa Y, Yamamoto S, Sakatani M. Chronic eosinophilic pneumonia due to visceral larva migrans. Intern Med 2002; 41: 478-482. https://doi.org/10.2169/internalmedicine.41.478
  12. Katz U, Shoenfeld Y. Pulmonary eosinophilia. Clin Rev Allergy Immunol 2008; 34: 367-371. https://doi.org/10.1007/s12016-007-8053-y
  13. Wechsler ME. Pulmonary eosinophilic syndromes. Immunol Allergy Clin North Am 2007; 27: 477-492. https://doi.org/10.1016/j.iac.2007.07.005
  14. Aubry A, Porcher R, Bottero J, Touratier S, Leblanc T, Brethon B, Rousselot P, Raffoux E, Menotti J, Derouin F, Ribaud P, Sulahian A. Occurrence and kinetics of false-positive Aspergillus galactomannan test results following treatment with beta-lactam antibiotics in patients with hematological disorders. J Clin Microbiol 2006; 44: 389-394. https://doi.org/10.1128/JCM.44.2.389-394.2006
  15. Surmont I, Stockman W. Gluconate-containing intravenous solutions: another cause of false-positive galactomannan assay reactivity. J Clin Microbiol 2007; 45: 1373. https://doi.org/10.1128/JCM.02373-06
  16. Wheat LJ, Hackett E, Durkin M, Connolly P, Petraitiene R, Walsh TJ, Knox K, Hage C. Histoplasmosis-associated cross-reactivity in the BioRad Platelia Aspergillus enzyme immunoassay. Clin Vaccine Immunol 2007; 14: 638-640. https://doi.org/10.1128/CVI.00479-06
  17. Murashige N, Kami M, Kishi Y, Fujisaki G, Tanosaki R. False-positive results of Aspergillus enzyme-linked immunosorbent assays for a patient with gastrointestinal graft-versus-host disease taking a nutrient containing soybean protein. Clin Infect Dis 2005; 40: 333-334.
  18. Ansorg R, van den Boom R, Rath PM. Detection of Aspergillus galactomannan antigen in foods and antibiotics. Mycoses 1997; 40: 353-357. https://doi.org/10.1111/j.1439-0507.1997.tb00249.x
  19. Kang YR, Kim SA, Jeon K, Koh WJ, Suh GY, Chung MP, Kim H, Kwon OJ, Kang ES, Um SW. Toxocariasis as a cause of new pulmonary infiltrates. Int J Tuberc Lung Dis 2013; 17: 412-417. https://doi.org/10.5588/ijtld.12.0273
  20. Sturchler D, Schubarth P, Gualzata M, Gottstein B, Oettli A. Thiabendazole vs. albendazole in treatment of toxocariasis: a clinical trial. Ann Trop Med Parasitol 1989; 83: 473-478.
  21. Kim MH, Jung JW, Kwon JW, Kim TW, Kim SH, Cho SH, Min KU, Kim YY, Chang YS. A case of recurrent toxocariasis presenting with urticaria. Allergy Asthma Immunol Res 2010; 2: 267-270. https://doi.org/10.4168/aair.2010.2.4.267
  22. Yoshikawa M. Duration of treatment with albendazole for hepatic toxocariasis. Nat Clin Pract Gastroenterol Hepatol 2009; 6: E1-2.