Korean Journal of Biological Psychiatry (생물정신의학)

The Korean Society of Biological Psychiatry (대한생물정신의학회)
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Total Intracranial Volume Measurement for Children by Using an Automatized Program

자동화 프로그램을 이용한 아동의 전체두개강내용적 평가

  • Lee, Jeonghwan (Department of Psychiatry, College of Medicine, Chungbuk National University) ;
  • Kim, Ji-Eun (Department of Psychiatry, College of Medicine, Chungbuk National University) ;
  • Im, Sungjin (Department of Psychiatry, College of Medicine, Chungbuk National University) ;
  • Ju, Gawon (Department of Psychiatry, College of Medicine, Chungbuk National University) ;
  • Kim, Siekyeong (Department of Psychiatry, College of Medicine, Chungbuk National University) ;
  • Son, Jung-Woo (Department of Psychiatry, College of Medicine, Chungbuk National University) ;
  • Shin, Chul-Jin (Department of Psychiatry, College of Medicine, Chungbuk National University) ;
  • Lee, Sang-Ick (Department of Psychiatry, College of Medicine, Chungbuk National University) ;
  • Ghim, Hei-Rhee (Department of Psychology, Chungbuk National University)
  • 이정환 (충북대학교 의과대학 정신건강의학교실) ;
  • 김지은 (충북대학교 의과대학 정신건강의학교실) ;
  • 임성진 (충북대학교 의과대학 정신건강의학교실) ;
  • 주가원 (충북대학교 의과대학 정신건강의학교실) ;
  • 김시경 (충북대학교 의과대학 정신건강의학교실) ;
  • 손정우 (충북대학교 의과대학 정신건강의학교실) ;
  • 신철진 (충북대학교 의과대학 정신건강의학교실) ;
  • 이상익 (충북대학교 의과대학 정신건강의학교실) ;
  • 김혜리 (충북대학교 심리학과)
  • Received : 2014.05.30
  • Accepted : 2014.06.24
  • Published : 2014.08.28
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Abstract

Objectives Total intracranial volume (TIV) is a major nuisance of neuroimaging research for interindividual differences of brain structure and function. Authors intended to prove the reliability of the atlas scaling factor (ASF) method for TIV estimation in FreeSurfer by comparing it with the results of manual tracing as reference method. Methods The TIVs of 26 normal children and 26 children with attention-deficit hyperactivity disorder (ADHD) were obtained by using FreeSurfer reconstruction and manual tracing with T1-weighted images. Manual tracing performed in every 10th slice of MRI dataset from midline of sagittal plane by one researcher who was blinded from clinical data. Another reseacher performed manual tracing independently for randomly selected 20 dataset to verify interrater reliability. Results The interrater reliability was excellent (intraclass coefficient = 0.91, p < 7.1e-07). There were no significant differences of age and gender distribution between normal and ADHD groups. No significant differences were found between TIVs from ASF method and manual tracing. Strong correlation between TIVs from 2 different methods were shown (r = 0.90, p < 2.2e-16). Conclusions The ASF method for TIV estimation by using FreeSurfer showed good agreement with the reference method. We can use the TIV from ASF method for correction in analysis of structural and functional neuroimaging studies with not only elderly subjects but also children, even with ADHD.

Keywords

References

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