Biomolecules & Therapeutics

  • 제22권5호
  • /
  • Pages.438-444
  • /
  • 2014
  • /
  • 1976-9148(pISSN)
  • /
  • 2005-4483(eISSN)
한국응용약물학회 (The Korean Society of Applied Pharmacology)
권호 표지
DOI QR코드

DOI QR Code

The Leaves of Broussonetia kazinoki Siebold Inhibit Atopic Dermatitis-Like Response on Mite Allergen-Treated Nc/Nga Mice

  • Lee, Hoyoung (Medical Research Division, Korea Institute of Oriental Medicine) ;
  • Ha, Hyekyung (Herbal Medicine Formulation Research Group, Korea Institute of Oriental Medicine) ;
  • Lee, Jun Kyoung (Herbal Medicine Formulation Research Group, Korea Institute of Oriental Medicine) ;
  • Park, Sang-Joon (Department of Histology, College of Veterinary Medicine, Kyungpook National University) ;
  • Jeong, Seung-Il (Jeonju Biomaterials Institute) ;
  • Shin, Hyeun Kyoo (Herbal Medicine Formulation Research Group, Korea Institute of Oriental Medicine)
  • 투고 : 2014.02.20
  • 심사 : 2014.06.25
  • 발행 : 2014.09.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Broussonetia kazinoki Siebold. (B. kazinoki) has long been used in the manufacture of paper in Asian countries. Although B. kazinoki leaves (BK) have been employed in dermatological therapy, use of BK has not been tested in patients with atopic dermatitis (AD). Using Nc/Nga mice, which are genetically predisposed to develop AD-like skin lesions, we confirmed the efficacy of BK in AD treatment. BK extract was applied topically to Dermatophagoides farinae-induced AD-like lesions in Nc/Nga mice, and the effects were assessed both clinically and by measuring skin thickness on the back and ears. We measured the effects of BK extract on plasma levels of IgE and IL-4. We also measured the ability of BK extract to inhibit the secretion of hTARC in HaCaT cells after stimulation by TNF-${\alpha}$ and IFN-${\gamma}$. We found that BK extract significantly reduced ear and dorsal skin thickness and the clinical signs of AD, as well as significantly down-regulating the plasma levels of IgE and IL-4 (p<0.01 for each comparison). Moreover, $500{\mu}g/mL$ of BK extract inhibited hTARC secretion in HaCaT cells by activated TNF-${\alpha}$/IFN-${\gamma}$ by about 87%. These findings suggest that topical application of BK extract has excellent potential in the treatment of AD.

키워드

참고문헌

  1. Aioi, A., Tonogaio, H., Suto, H., Hamada, K., Ra, C. R., Ogawam, H., Mibach, H. and Matsuda. H. (2001) Impairment of skin barrier function in Nc/Nga Tnd mice as a possible model or atopic dermatitis. Br. J. Dermatol. 144, 12-18. https://doi.org/10.1046/j.1365-2133.2001.03946.x
  2. Athanasiadou, S., Kyruazakis, I., Jackson, F. and Coop. R. L. (2001) Direct anthelmintic effects of condensed tannins towards different gastrointestinal nematodes of sheep: in vitro and in vivo studies. Vet. Parasitol. 99, 205-219. https://doi.org/10.1016/S0304-4017(01)00467-8
  3. Bakhshaee, M., Jabbari, F., Hoseini, S., Farid, R., Sadeghian, M. H., Rajati, M., Mohamadpoor, A. H., Movahhed, R. and Zamani, M. A. (2011) Effect of silymarin in the treatment of allergic rhinitis. Otolaryngol. Head Neck Surg.145, 904-909. https://doi.org/10.1177/0194599811423504
  4. Bergmann, R. L., Edenharter, G., Bergmann, K. E., Forster, J., Bauer, C. P., Wahn. V., Zepp. F. and Wahn U. (1998) Atopic dermatitis in early infancy predicts allergic airway disease at 5 years. Clin. Exp. Allergy 28, 965-970. https://doi.org/10.1046/j.1365-2222.1998.00371.x
  5. Buys, L. M. (2007) Treatment option for atopic dermatitis. Am. Fam. Physician 75, 523-528.
  6. Cha, J. Y., Kim, Y. T., Kim, H. S. and Cho. Y. S. (2008) Antihyperglycemic effect of stem bark posder from paper mulberry (Broussonetia kazinoki Sieb.) in type 2 diabetic Otsuka Long-Evans Tokushima fatty rats. J. Med. Food 11, 499-505. https://doi.org/10.1089/jmf.2007.0028
  7. Chang, T. S., and Shiung Y. Y. (2006) Anti-IgE as a mast cell-stabilizing therapeutic agent. J. Allergy Clin. Immunol. 117, 1203-1212. https://doi.org/10.1016/j.jaci.2006.04.005
  8. Diaz, P., Jeong, S. C., Lee, S., Khoo, C. and Koyyalamudi, S. R. (2012) Antioxidant and anti-inflammatory activities of selected medicinal plants and fungi containing phenolic and flavonoid compounds. Chin. Med. 7, 26. https://doi.org/10.1186/1749-8546-7-26
  9. Fedeli, D., Berrettini, M., Gabryelak, T. and Falcioni. G. (2004) The effect of some tannins on trout erythrocytes exposed to oxidative stress. Mutat. Res. 563, 89-96. https://doi.org/10.1016/j.mrgentox.2004.06.008
  10. Gambichler, T., Breuckmann, F., Boms, S., Altmeyer, P. and Kreuter. A. (2005) Narrowband UVB phototherapy in skin conditions beyond psoriasis. J. Am. Acad. Dermatol. 52, 660-670. https://doi.org/10.1016/j.jaad.2004.08.047
  11. Grewe, S. R., Chan, S. C. and Hanifin. J. M. (1982) Evaluated leukocyte cyclic AMP-phosphodiesterase in atopic disease: a possible mechanism for cyclic AMP-agonist hyporesponsiveness. J. Allergy Clin. Immunol. 70, 452-457. https://doi.org/10.1016/0091-6749(82)90008-2
  12. Grone. A. (2002) Keratinocyte and cytokines. Vet. Immunol. Immunopathol. 88, 1-12. https://doi.org/10.1016/S0165-2427(02)00136-8
  13. Hanifin, J. M., Paller, A. S., Eichenfield, L., Clark, R. A., Korman, N., Weinstein, G., Caro, I., Jaracz, E. and Rico. M. J. (2005) US Tacrolimus Ointment Study Group. Efficacy and safety of tacrolimus ointment treatment for up to 4 years in patients with atopic dermatitis. J. Am. Acad. Dermatol. 53, S186-S194. https://doi.org/10.1016/j.jaad.2005.04.062
  14. Hwang, J. H., and Lee. B. M. (2007) Inhibitory effects of plant extracts on tyrosinase, L-DOPA oxidation, and melanin synthesis. J. Toxicol. Environ. Health A 70, 393-407. https://doi.org/10.1080/10937400600882871
  15. Kang, J. S., Yoon, W. K., Han, M. H., Lee, H., Lee, C. W., Lee, K. H., Han, S. B., Lee, K., Yang, K. H., Park, S. K. and Kim. H. M. (2008) Inhibition of atopic dermatitis by topical application of silymarin in Nc/Nga mice. Int Immunopharmacol. 8, 1475-1480. https://doi.org/10.1016/j.intimp.2008.06.004
  16. Kang, J. S., Jeon, Y. J., Kim, H. M., Han, S. H. and Yang. K. H. (2002) Inhibition of inducible nitric-oxide synthase expression by silymarin in lipopolysaccharide-stimulated macrophages. J. Phamacol. Exp. Ther. 302, 138-144. https://doi.org/10.1124/jpet.302.1.138
  17. Matsuda, H., Watanabe, N., Geba, G. P., Sperl, J., Tsudzuki, M., Hiroi, J., Marsumoto, M., Ushio, H., Saito, S., Askenase, P. W. and Ra. C. (1997) Development of atopic dermatitis-like lesion with IgE hyperproduction in Nc/Nga mice. Int. Immunol. 9, 461-466. https://doi.org/10.1093/intimm/9.3.461
  18. Nakashima, H., Mrrakami, T., Yamamoto, N., Sakagami, H., Tanuma, S., Hatano, T., Yoshida, T. and Okuda. T. (1992) Inhibition of human immunodeficiency viral replication of tannins and related compounds. Antiviral Res. 18, 91-103. https://doi.org/10.1016/0166-3542(92)90008-S
  19. Qi, X. F., Kim, D. H., Yoon, Y. S., Li, J. H., Song, S. B., Jin, D., Huang, X. Z., Teng, Y. C. and Lee. K. J. (2009) The adenylyl cyclase-cAMP system suppresses TARC/CCL17 and MDC/CCL22 production through p38K MAPK and NF-kB in HaCaT keratinocytes. Mol. Immunol. 46, 1925-1934. https://doi.org/10.1016/j.molimm.2009.03.018
  20. Romagnani, S. (2007) Coming back to a missing immune deviation as the main explanatory mechanism for the hygiene hypothesis. J. Allergy Clin. Immunol. 119, 1511-1513. https://doi.org/10.1016/j.jaci.2007.04.005
  21. Romano, B., Pagano, E., Montanaro, V., Fortunato, A. L., Milic, N. and Borrelli, F. (2013) Novel insights into the pharmacology of flavonoids. Phytother. Res. 27, 1588-1596. https://doi.org/10.1002/ptr.5023
  22. Ryu, J. H., Ahn, H. and Lee. H. J. (2003) Inhibition of nitric oxide production on LPS-activated macrophages by kazinol B from Broussonetia kazinoki. Fitoterapia 74, 350-354. https://doi.org/10.1016/S0367-326X(03)00062-5
  23. Saeki, H., and Tamaki, K. (2006) Thymus and activation regulated chemokine (TARC)/CCL17 and skin diseases. J. Dermatol. Sci. 43, 75-84. https://doi.org/10.1016/j.jdermsci.2006.06.002
  24. Sandoval-Lopez, G., and Teran, L.M. (2001) TARC: novel mediator of allergic inflammation. Clin. Exp. Allergy 31, 1809-1812. https://doi.org/10.1046/j.1365-2222.2001.01268.x
  25. Salpietro, D. C., Naccari, F., Polimeni, I. and Pellegrino, C. (1998) Reduced plasma c-AMP levels in children with atopic dermatitis. Pediatr. Allergy Immunol. 9, 130-132. https://doi.org/10.1111/j.1399-3038.1998.tb00358.x
  26. Singleton, V. L., Orthofer, R. and Lamuela-Raventos. R. M. (1999) Analysis of total phenols and other oxidation substances and antioxidants by means of Folin-Ciocalteu reagent, In Methods in Enxymology (Packer L, Ed), pp152-178. Academic Press, San Diego.
  27. Sumiyoshi, K., Nakao, A., Setoguchi, Y., Tsuboi, R., Okumura, K. and Ogawa. H. (2003) TGF-${\beta}$/Smad signaling inhibits IFN-${\gamma}$ and TNF-${\alpha}$-induced TARC (CCL17) production in HaCaT cells. J. Dermatol. Sci. 31, 53-58. https://doi.org/10.1016/S0923-1811(02)00141-X
  28. Tsukamoto, D., Shibano, M. and Kusano. G. (2001) Studies on the constituents of Broussonetia species X. Six new alkaloids from Broussonetia Kazinoki Sieb. Chem. Pharm. Bull. 49, 1487-1491. https://doi.org/10.1248/cpb.49.1487
  29. Yamamoto, M., Haruna, T., Yasui, K., Takahashi, H., Iduhara, M., Takaki, S., Deguchi, M. and Arimura. A. (2007) A novel atopic dermatitis model induced by topical application with Dermatophagoides farina extract in Nc/Nga mice. Allergol. Int. 56, 139-148. https://doi.org/10.2332/allergolint.O-06-458
  30. Zhang, P. C., Wang, S., Wu, Y., Chen, R. Y. and Yu. D. Q. (2001) Five new diprenylated flavonols from the leaves of Broussonetia Kazinoki. J. Nat. Prod. 64, 1206-1209. https://doi.org/10.1021/np010283o

피인용 문헌

  1. Kazinol-E is a specific inhibitor of ERK that suppresses the enrichment of a breast cancer stem-like cell population vol.470, pp.2, 2016, https://doi.org/10.1016/j.bbrc.2016.01.066
  2. Kazinol B from Broussonetia kazinoki improves insulin sensitivity via Akt and AMPK activation in 3T3-L1 adipocytes vol.112, 2016, https://doi.org/10.1016/j.fitote.2016.05.006
  3. Forsythia suspensa Suppresses House Dust Mite Extract-Induced Atopic Dermatitis in NC/Nga Mice vol.11, pp.12, 2016, https://doi.org/10.1371/journal.pone.0167687
  4. Combined Skin Moisturization of Liposomal Serine Incorporated in Hydrogels Prepared with Carbopol ETD 2020, Rhesperse RM 100 and Hyaluronic Acid vol.19, pp.6, 2015, https://doi.org/10.4196/kjpp.2015.19.6.543
  5. Siebold Fruit Extract against Palmitate-Induced Lipotoxicity in Mesangial Cells vol.2019, pp.1741-4288, 2019, https://doi.org/10.1155/2019/4509403
  6. Traditional Herbal Medicines, Newer Herbs and Other Novel Approaches Integrated in Herbal Medicine for Atopic Dermatitis-A Narrative Review vol.14, pp.None, 2014, https://doi.org/10.2174/1574885514666191018165209
  7. The Protective and Inhibitory Effect of Antioxidants Found in Broussonetia kazinoki Siebold against Oxidative DNA Damage vol.32, pp.6, 2019, https://doi.org/10.7732/kjpr.2019.32.6.714
  8. Anti-Allergic and Anti-Inflammatory Effects of Undecane on Mast Cells and Keratinocytes vol.25, pp.7, 2014, https://doi.org/10.3390/molecules25071554
  9. Antioxidant evaluation-guided chemical profiling and structure-activity analysis of leaf extracts from five trees in Broussonetia and Morus (Moraceae) vol.10, pp.None, 2014, https://doi.org/10.1038/s41598-020-61709-5
  10. Atopic dermatitis: new insight into the etiology, pathogenesis, diagnosis and novel treatment strategies vol.43, pp.2, 2014, https://doi.org/10.1080/08923973.2021.1889583