Polymer(Korea) (폴리머)

The Polymer Society of Korea (한국고분자학회)
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Preparation and Release Behavior of Atorvastatin Calcuim - Encapsulated Polyoxalate Microspheres

아토르바스타틴 칼슘을 함유한 폴리옥살레이트 미립구의 제조 및 방출거동

  • Lee, Cheon Jung (Dept. of BIN Fusion Technology, Polymer Fusion Research Center & Dept. of PolymerNano Science Technology, Chonbuk National Unviersity) ;
  • Kim, Su Young (Dept. of BIN Fusion Technology, Polymer Fusion Research Center & Dept. of PolymerNano Science Technology, Chonbuk National Unviersity) ;
  • Lee, Hyun Gu (Dept. of BIN Fusion Technology, Polymer Fusion Research Center & Dept. of PolymerNano Science Technology, Chonbuk National Unviersity) ;
  • Yang, Jaewon (Dept. of BIN Fusion Technology, Polymer Fusion Research Center & Dept. of PolymerNano Science Technology, Chonbuk National Unviersity) ;
  • Park, Jin Young (Dept. of BIN Fusion Technology, Polymer Fusion Research Center & Dept. of PolymerNano Science Technology, Chonbuk National Unviersity) ;
  • Cha, Se Rom (Dept. of BIN Fusion Technology, Polymer Fusion Research Center & Dept. of PolymerNano Science Technology, Chonbuk National Unviersity) ;
  • Lim, Dong-Kwon (Dept. of BIN Fusion Technology, Polymer Fusion Research Center & Dept. of PolymerNano Science Technology, Chonbuk National Unviersity) ;
  • Lee, Dongwon (Dept. of BIN Fusion Technology, Polymer Fusion Research Center & Dept. of PolymerNano Science Technology, Chonbuk National Unviersity) ;
  • Khang, Gilson (Dept. of BIN Fusion Technology, Polymer Fusion Research Center & Dept. of PolymerNano Science Technology, Chonbuk National Unviersity)
  • 이천중 (전북대학교 BIN융합공학과, 고분자나노공학과, 고분자융합소재연구소) ;
  • 김수영 (전북대학교 BIN융합공학과, 고분자나노공학과, 고분자융합소재연구소) ;
  • 이현구 (전북대학교 BIN융합공학과, 고분자나노공학과, 고분자융합소재연구소) ;
  • 양재원 (전북대학교 BIN융합공학과, 고분자나노공학과, 고분자융합소재연구소) ;
  • 박진영 (전북대학교 BIN융합공학과, 고분자나노공학과, 고분자융합소재연구소) ;
  • 차세롬 (전북대학교 BIN융합공학과, 고분자나노공학과, 고분자융합소재연구소) ;
  • 임동권 (전북대학교 BIN융합공학과, 고분자나노공학과, 고분자융합소재연구소) ;
  • 이동원 (전북대학교 BIN융합공학과, 고분자나노공학과, 고분자융합소재연구소) ;
  • 강길선 (전북대학교 BIN융합공학과, 고분자나노공학과, 고분자융합소재연구소)
  • Received : 2014.03.04
  • Accepted : 2014.04.05
  • Published : 2014.09.25
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Abstract

Atorvastatin calcium-loaded polyoxalate (POX) microspheres were prepared by an emulsion solvent-evaporation/ extraction method of oil-in-oil-in-water ($O_1/O_2/W$) for sustained release. We investigated the release behavior according to initial drug ratio, molecular weight ($M_w$) and concentration of POX and concentration of emulsifier. The microsphere was characterized on the surface, the cross-section morphology and the behavior of atorvastatin calcium release for 10 days by scanning electron microscopy (SEM) and high performance liquid chromatography (HPLC). The analysis of crystallization was analyzed to use X-ray diffraction (XRD), differential scanning calorimeter (DSC) and Fourier transform infrared (FTIR). These results showed that the release behaviors can be controlled by preparation conditions.

생분해성 고분자인 폴리옥살레이트(POX)를 이용하여 아토르바스타틴 칼슘을 함유한 미립구를 $O_1/O_2/W$ 에멀젼용매증발법으로 제조하였다. 약물의 함량, POX의 분자량과 농도 그리고 유화제인 PVA의 농도를 달리하여 아토르바스타틴 칼슘이 함유된 미립구의 형태학적 특성, 방출거동, 분해거동 등을 평가하였다. 아토르바스타틴 칼슘이 함유된 미립구에 대한 물리화학적 성질 및 형태를 X선 회절분석법과 시차주사열량계, 적외선 분광분석기, 그리고 주사 전자 현미경을 이용하여 분석하였다. 또한 미립구의 방출거동과 포접률을 분석하기 위하여 고성능 액체 크로마토그래피를 이용하였으며 분해성을 분석하기 위하여 10일 동안 in vitro 실험을 통해 관찰하였다. 본 연구를 통하여 제조 조건에 따라 아토르바스타틴 칼슘을 함유한 POX 미립구의 약물방출과 형태 제어를 확인할 수 있었으며, 이를 통해 아토르바스타틴 뿐만 아니라 유사 약물의 약물 방출과 형태 제어에 도움이 될 것으로 기대된다.

Keywords

Acknowledgement

Supported by : 한국연구재단

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