Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Lack of Association between the MTHFR C677T Polymorphism and Lung Cancer in a Turkish Population

  • Yilmaz, Meral (Department of Research Centre, Faculty of Medicine, Cumhuriyet University) ;
  • Kacan, Turgut (Department of Medical Oncology, Faculty of Medicine, Cumhuriyet University) ;
  • Sari, Ismail (Department of Medical Biochemistry, Faculty of Medicine, Cumhuriyet University) ;
  • Kilickap, Saadettin (Department of Medical Oncology, Faculty of Medicine, Hacettepe University)
  • Published : 2014.08.15
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Abstract

Background: In this case-control study, we aimed to investigate the relationship between the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and lung cancer. Materials and Methods: Total 200 individuals including 100 patients with lung cancer and 100 controls were analyzed. Genotyping of MTHFR C677T was performed using PCR and RFLP methods. Results: The majority of the patients were men and 90% were smokers. We found that the risk ratio for development of LC was 13-times higher in smokers compared with non-smokers between patient and control groups in our study (OR:13.5, 95%CI:6.27-29.04, p:0.0001). Besides, the risk ratio for development of LC was nine times higher in individuals with cancer history in their family than those without cancer history (OR:9.65, 95%CI: 2.79-33.36; p:0.0001). When genotype distributions and allele frequencies were analyzed in the study groups, no significant difference was apparent (${\chi}^2$:0.53, p=0.76). In addition, no correlation between genotypes of MTHFRC677T polymorphism and histological type of LC was found (${\chi}^2$:0.99, p=0.60). Conclusions: These results suggest that there was no association between the MTHFR C677T polymorphism and lung cancer in the Turkish population.

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References

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