Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Lack of Relation of Survivin Gene Expression with Survival and Surgical Prognostic Factors in Endometrial Carcinoma Patients

  • Aksoy, Rifat Taner (Obstetrics and Gynecology, Etlik Zubeyde Hanim Women's Health Training and Research Hospital) ;
  • Thran, Ahmet Taner (Obstetrics and Gynecology, Etlik Zubeyde Hanim Women's Health Training and Research Hospital) ;
  • Boran, Nurettin (Obstetrics and Gynecology, Etlik Zubeyde Hanim Women's Health Training and Research Hospital) ;
  • Tokmak, Aytekin (Zekai Tahir Burak Women Health Education and Research Hospital) ;
  • Isikdogan, Betul Zuhal (Obstetrics and Gynecology, Etlik Zubeyde Hanim Women's Health Training and Research Hospital) ;
  • Dogan, Mehmet (Department of Pathology, Oncology Education and Research Hospital) ;
  • Thlunay, Hakki Gokhan (Obstetrics and Gynecology, Etlik Zubeyde Hanim Women's Health Training and Research Hospital)
  • Published : 2014.08.30
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Abstract

Background: The relation ofsurvivin gene expression to survival and surgical prognostic factors in the patients with endometrial carcinoma is unclear. Materials and Methods: In this study, 62 cases who were operated due to endometrial carcinoma were investigated between 2003 and 2011 in the the gynecological oncology clinic of Female Disease Training and Investigation Hospital of Etlik Zubeyde, Hanim, Turkey. Clinical and surgical prognostic factors were investigated by screening the records of these cases. With the standard streptavidin-biotin immune peroxidase method, cytoplasmic and nuclear expression of survivin was investigated in sections with specific antibodies (1:100, diagnostic Bio Systems, USA) primer. The aim was to elucidate any relation between survivin expression and defined prognostic factors and survival. Results: There was no statistically significant relationship between cytoplasmic and nuclear indexes identified for survivin and age, body mass index, the levels of preoperative hemoglobin, platelet and Ca 125, stage, grade, lymph node meastasis, the number of meta statical lymph nodes (total, paraaortic and pelvic), myometrial invasion, serosal invasion, adnexal involvement, the presence of acid in the first diagnosis, the involvement of omentum, the adjuvant treatment application of the cases, the presence of recurrence and rate of mortality (p>0.05). Statistical significance was noted for the presence of advanced stage lymph node metastasis (pelvic, paraaortic, pelvic and paraaortic), serosal involvement, positive cytology, lymph vascular space invasion, intra abdominal metastasis, and omentum involvement. When investigated the relation between cytoplasmic and nuclear survivin indexes and total survival, the result was not statistically significant (p>0.05). Conclusions: In our study, there was no statistically significant relationship between the rates of cytoplasmic and nuclear survivin expression with identified prognostic factors and total or non-disease survival.

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References

  1. Baser E, Togrul C, Ozgu E, et al (2013). Sperm-associated antigen 9 is a promising marker for early diagnosis of endometrial cancer. Asian Pac J Cancer Prev, 14,7635-8. https://doi.org/10.7314/APJCP.2013.14.12.7635
  2. Binesh F, Akhavan A, Behniafard N, et al (2014). Endometrial adenocarcinoma: cl inicopathologic and survival characteristics in Yazd, Iran. Asian Pac J Cancer Prev, 15, 2797-801. https://doi.org/10.7314/APJCP.2014.15.6.2797
  3. Cao XQ, Lu HS, Zhang L, et al (2014). MEKK3 and survivin expression in cervical cancer: association with clinicopathological factors and prognosis. Asian Pac J Cancer Prev, 15, 5271-6. https://doi.org/10.7314/APJCP.2014.15.13.5271
  4. Damitri TD, Shamsuddin SH, Idris FM, et al (2014). Rapamycin and PF4 induce apoptosis by upregulating bax and downregulating survivin inMNU-induced breast cancer. Asian Pac J Cancer Prev. 15, 3939-44. https://doi.org/10.7314/APJCP.2014.15.9.3939
  5. Erkanli S, Bolat F, Kayaselcuk F, et al (2007). COX-2 and survivin are overexpressed and positively correlated in endometrial carcinoma. Gynecol Oncol, 104, 320-325. https://doi.org/10.1016/j.ygyno.2006.08.044
  6. Felix AS, Weissfeld JL, Stone RA (2010). Factors associated with type I and type II endometrial cancer. Cancer Causes Control, 21, 1851. https://doi.org/10.1007/s10552-010-9612-8
  7. Karami H, Baradaran B, Esfahani A, et al (2013). siRNAmediated silencing of survivin inhibits proliferation and enhances etoposide chemosensitivity in acute myeloid leukemia cells. Asian Pac J Cancer Prev, 14, 7719-24. https://doi.org/10.7314/APJCP.2013.14.12.7719
  8. Lurain JR, Rice BL, Rademaker AW (1991). Prognostic factors associated with recurrence in clinical stage I adenocarcinoma of endometrium. Obstet. Gynecol, 78, 63-9.
  9. Okada E, Murai Y, Matsui K, et al (2001). Survivin expression in tumour cell nuclei is predictive of a favorable prognosis ingastric cancer patients. Cancer Lett, 163, 109-16. https://doi.org/10.1016/S0304-3835(00)00677-7
  10. Pallares J, Martinez-Guitarte JL, Xavier D (2005). Survivin expression in endometrial carcinoma a tissue microarray study with correlation with PTEN and STAT-3. Int J Gynecol Pathol, 24, 247-53. https://doi.org/10.1097/01.pgp.0000163849.37129.d4
  11. Rowlands IJ, Weinstein P, Nagle CM, et al (2011). Season of birth and risk of endometrial cancer. Asian Pac J Cancer Prev, 12, 1193-6.
  12. Silverberg E, Boring C, Squires A (1990). Cancer statistics. CA Cancer J Clin, 90, 40.
  13. Srivastava AK, Singh PK, Srivastava K, et al (2013). Diagnostic role of survivin in urinary bladder cancer. Asian Pac J Cancer Prev. 14, 81-5. https://doi.org/10.7314/APJCP.2013.14.1.81
  14. Takai N, Miyazaki T, Nishida M (2002). Survivin expression correlates with clinical stage, histological grade, invasive behavior and survival rate in endometrial carcinoma. Cancer Lett. 184, 105-16. https://doi.org/10.1016/S0304-3835(02)00190-8
  15. Yuan SF, Zhu LJ, Zheng WE, et al (2012). Expression of betatubulin III and survivin in advance stage breast cancer correlates with chemotherapeutic effects of docetaxel. Asian Pac J Cancer Prev, 13, 361-5. https://doi.org/10.7314/APJCP.2012.13.1.361

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