Asian Pacific Journal of Cancer Prevention

  • 제15권17호
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  • Pages.7181-7185
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  • 2014
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  • 1513-7368(pISSN)
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  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
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A Cyclin D1 (CCND1) Gene Polymorphism Contributes to Susceptibility to Papillary Thyroid Cancer in the Turkish Population

  • Aytekin, Turkan (Department of Biology, Faculty of Arts and Sciences, University of Gaziantep) ;
  • Aytekin, Alper (Department of General Surgery, Faculty of Medicine, University of Gaziantep) ;
  • Maralcan, Gokturk (Department of General Surgery, Faculty of Medicine, University of Gaziantep) ;
  • Gokalp, M. Avni (Department of General Surgery, Faculty of Medicine, University of Gaziantep) ;
  • Ozen, Dogukan (Department of Biostatistics, Faculty of Veterinary Medicine, University of Ankara) ;
  • Borazan, Ersin (Department of General Surgery, Faculty of Medicine, University of Gaziantep) ;
  • Yilmaz, Latif (Department of General Surgery, Faculty of Medicine, University of Gaziantep)
  • 발행 : 2014.09.15
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초록

Cyclin D1 is an important positive regulator of the G1/S phase of the cell cycle. We investigated the association between the CCND1 G870A polymorphism and susceptibility to papillary thyroid cancer in Turkish people. This study covered 102 patients with papillary thyroid cancer and 174 healthy controls. CCND1 genotyping was determined by the PCR-RFLP method. We found that the A allele frequency was higher in the cases than in the controls (p=0.042). On stratification analysis, papillary thyroid cancer risk was significantly elevated in individuals older than 45 years with the A allele (OR=1.91, 95% CI, 1.09-3.35, p=0.024) and in females with the A allele (OR=1.73, 95% CI, 1.06-2.84, p=0.029), compared to the G allele. According to the subject age, there was an increased papillary thyroid cancer risk for the individuals older than 45 years with the AA genotype (OR=2.28, 95% CI, 1.02-5.13, p=0.046) compared to the AG+GG combined genotypes. In conclusion, it is suggested that the CCND1 G870A polymorphism may contribute to the susceptibility to papillary thyroid cancer, especially in those who were older subjects ($45{\leq}$ years old) and female, in the Turkish population.

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참고문헌

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피인용 문헌

  1. CCND1 Splice Variant as A Novel Diagnostic and Predictive Biomarker for Thyroid Cancer vol.10, pp.11, 2018, https://doi.org/10.3390/cancers10110437
  2. Identification of key genes of papillary thyroid cancer using integrated bioinformatics analysis vol.41, pp.10, 2018, https://doi.org/10.1007/s40618-018-0859-3