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Enhanced compatibility and initial stability of Ti6Al4V alloy orthodontic miniscrews subjected to anodization, cyclic precalcification, and heat treatment

  • Oh, Eun-Ju (Sun Dental Hospital) ;
  • Nguyen, Thuy-Duong T. (Department of Dental Biomaterials and Institute of Oral Bioscience, Brain Korea 21 Project, School of Dentistry, Chonbuk National University) ;
  • Lee, Seung-Youp (Department of Orthodontics, School of Dentistry, Chonbuk National University) ;
  • Jeon, Young-Mi (Department of Orthodontics, School of Dentistry, Chonbuk National University) ;
  • Bae, Tae-Sung (Department of Dental Biomaterials and Institute of Oral Bioscience, Brain Korea 21 Project, School of Dentistry, Chonbuk National University) ;
  • Kim, Jong-Gee (Department of Orthodontics, School of Dentistry, Chonbuk National University)
  • 투고 : 2013.12.27
  • 심사 : 2014.03.25
  • 발행 : 2014.09.25

초록

Objective: To evaluate the bioactivity, and the biomechanical and bone-regenerative properties of Ti6Al4V miniscrews subjected to anodization, cyclic precalcification, and heat treatment (APH treatment) and their potential clinical use. Methods: The surfaces of Ti6Al4V alloys were modified by APH treatment. Bioactivity was assessed after immersion in simulated body fluid for 3 days. The hydrophilicity and the roughness of APH-treated surfaces were compared with those of untreated (UT) and anodized and heat-treated (AH) samples. For in vivo tests, 32 miniscrews (16 UT and 16 APH) were inserted into 16 Wistar rats, one UT and one APH-treated miniscrew in either tibia. The miniscrews were extracted after 3 and 6 weeks and their osseointegration (n = 8 for each time point and group) was investigated by surface and histological analyses and removal torque measurements. Results: APH treatment formed a dense surface array of nanotubular TiO2 layer covered with a compact apatite-like film. APH-treated samples showed better bioactivity and biocompatibility compared with UT and AH samples. In vivo, APH-treated miniscrews showed higher removal torque and bone-to-implant contact than did UT miniscrews, after both 3 and 6 weeks (p < 0.05). Also, early deposition of densely mineralized bone around APH-treated miniscrews was observed, implying good bonding to the treated surface. Conclusions: APH treatment enhanced the bioactivity, and the biomechanical and bone regenerative properties of the Ti6Al4V alloy miniscrews. The enhanced initial stability afforded should be valuable in orthodontic applications.

키워드

참고문헌

  1. Ikeda H, Rossouw PE, Campbell PM, Kontogiorgos E, Buschang PH. Three-dimensional analysis of peribone- implant contact of rough-surface miniscrew implants. Am J Orthod Dentofacial Orthop 2011; 139:e153-63. https://doi.org/10.1016/j.ajodo.2010.09.022
  2. Kim SH, Lee SJ, Cho IS, Kim SK, Kim TW. Rotational resistance of surface-treated mini-implants. Angle Orthod 2009;79:899-907. https://doi.org/10.2319/090608-466.1
  3. Chang CS, Lee TM, Chang CH, Liu JK. The effect of microrough surface treatment on miniscrews used as orthodontic anchors. Clin Oral Implants Res 2009;20:1178-84. https://doi.org/10.1111/j.1600-0501.2009.01728.x
  4. Chaddad K, Ferreira AF, Geurs N, Reddy MS. Influence of surface characteristics on survival rates of mini-implants. Angle Orthod 2008;78:107-13. https://doi.org/10.2319/100206-401.1
  5. Wu X, Deng F, Wang Z, Zhao Z, Wang J. Biomechanical and histomorphometric analyses of the osseointegration of microscrews with different surgical techniques in beagle dogs. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008;106:644-50. https://doi.org/10.1016/j.tripleo.2008.05.031
  6. Suzuki EY, Suzuki B. Placement and removal torque values of orthodontic miniscrew implants. Am J Orthod Dentofacial Orthop 2011;139:669-78. https://doi.org/10.1016/j.ajodo.2010.11.017
  7. Wu TY, Kuang SH, Wu CH. Factors associated with the stability of mini-implants for orthodontic anchorage: a study of 414 samples in Taiwan. J Oral Maxillofac Surg 2009;67:1595-9. https://doi.org/10.1016/j.joms.2009.04.015
  8. Chen Y, Kang ST, Bae SM, Kyung HM. Clinical and histologic analysis of the stability of microimplants with immediate orthodontic loading in dogs. Am J Orthod Dentofacial Orthop 2009;136:260-7. https://doi.org/10.1016/j.ajodo.2007.10.046
  9. Lee NK, Baek SH. Effects of the diameter and shape of orthodontic mini-implants on microdamage to the cortical bone. Am J Orthod Dentofacial Orthop 2010;138:8.e1-8.
  10. Morais LS, Serra GG, Muller CA, Andrade LR, Palermo EF, Elias CN, et al. Titanium alloy mini-implants for orthodontic anchorage: immediate loading and metal ion release. Acta Biomater 2007;3:331-9. https://doi.org/10.1016/j.actbio.2006.10.010
  11. Chen F, Terada K, Hanada K, Saito I. Anchorage effect of osseointegrated vs nonosseointegrated palatal implants. Angle Orthod 2006;76:660-5.
  12. Park IS, Yang EJ, Bae TS. Effect of cyclic precalcification of nanotubular TiO2 layer on the bioactivity of titanium implant. Biomed Res Int 2013; 2013:293627.
  13. Nguyen TDT, Park IS, Lee MH, Bae TS. Enhanced biocompatibility of a pre-calcified nanotubular TiO2 layer on Ti-6Al-7Nb alloy. Surf Coatings Technol 2013;236:127-34. https://doi.org/10.1016/j.surfcoat.2013.09.038
  14. Eaninwene G 2nd, Yao C, Webster TJ. Enhanced osteoblast adhesion to drug-coated anodized nanotubular titanium surfaces. Int J Nanomedicine 2008; 3:257-64.
  15. Peng L, Mendelsohn AD, LaTempa TJ, Yoriya S, Grimes CA, Desai TA. Long-term small molecule and protein elution from TiO2 nanotubes. Nano Lett 2009;9:1932-6. https://doi.org/10.1021/nl9001052
  16. Webster TJ, Ejiofor JU. Increased osteoblast adhesion on nanophase metals: Ti, Ti6Al4V, and CoCrMo. Biomaterials 2004;25:4731-9. https://doi.org/10.1016/j.biomaterials.2003.12.002
  17. Yadav S, Upadhyay M, Liu S, Roberts E, Neace WP, Nanda R. Microdamage of the cortical bone during mini-implant insertion with self-drilling and selftapping techniques: a randomized controlled trial. Am J Orthod Dentofacial Orthop 2012;141:538-46. https://doi.org/10.1016/j.ajodo.2011.12.016
  18. Chen Y, Shin HI, Kyung HM. Biomechanical and histological comparison of self-drilling and selftapping orthodontic microimplants in dogs. Am J Orthod Dentofacial Orthop 2008;133:44-50. https://doi.org/10.1016/j.ajodo.2007.01.023
  19. Oh SH, Finõnes RR, Daraio C, Chen LH, Jin S. Growth of nano-scale hydroxyapatite using chemically treated titanium oxide nanotubes. Biomaterials 2005;26:4938-43. https://doi.org/10.1016/j.biomaterials.2005.01.048
  20. Yao C, Perla V, McKenzie JL, Slamovich EB, Webster TJ. Anodized Ti and Ti6Al4V possessing nanometer surface features enhances osteoblast adhesion. J Biomed Nanotechnol 2005;1:68-73. https://doi.org/10.1166/jbn.2005.008
  21. Salata LA, Burgos PM, Rasmusson L, Novaes AB, Papalexiou V, Dahlin C, et al. Osseointegration of oxidized and turned implants in circumferential bone defects with and without adjunctive therapies: an experimental study on BMP-2 and autogenous bone graft in the dog mandible. Int J Oral Maxillofac Surg 2007;36:62-71. https://doi.org/10.1016/j.ijom.2006.07.009
  22. Liou EJ, Pai BC, Lin JC. Do miniscrews remain stationary under orthodontic forces? Am J Orthod Dentofacial Orthop 2004;126:42-7. https://doi.org/10.1016/j.ajodo.2003.06.018

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  5. Surface properties and early murine pre-osteoblastic cell responses of anodized TiO₂ surfaces vol.42, pp.1, 2014, https://doi.org/10.21851/obr.42.01.201803.1
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