한국임상수의학회지 (Journal of Veterinary Clinics)

  • 제31권4호
  • /
  • Pages.313-315
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  • 2014
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  • 1598-298X(pISSN)
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  • 2384-0749(eISSN)
한국임상수의학회 (The Korean Society of Veterinary Clinics)
권호 표지

개에서 뇌하수체 왜소증의 증례: 멜라토닌의 경구 투약에 의한 탈모의 개선

A Case of Pituitary Dwarfism in a Dog: Improvement of Alopecia with Oral Melatonin

  • Oh, Seungkuk (BK21 Plus and College of Veterinary Medicine, Chonbuk National University) ;
  • Baek, Dae-Seung (BK21 Plus and College of Veterinary Medicine, Chonbuk National University) ;
  • Kim, Yunhye (BK21 Plus and College of Veterinary Medicine, Chonbuk National University) ;
  • Kim, Namsoo (BK21 Plus and College of Veterinary Medicine, Chonbuk National University) ;
  • Kim, Jonghoon (BK21 Plus and College of Veterinary Medicine, Chonbuk National University) ;
  • Kim, Namjung (Applied Entomology Division, National Academy of Agricultural Science, RDA) ;
  • Chung, Tae-Ho (Department of Animal Science, Joongbu Univeresity) ;
  • Kim, Ju-Min (DongA One Corporation) ;
  • Park, Jinho (BK21 Plus and College of Veterinary Medicine, Chonbuk National University) ;
  • Park, Chul (BK21 Plus and College of Veterinary Medicine, Chonbuk National University)
  • 심사 : 2014.08.12
  • 발행 : 2014.08.31
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초록

13개월령의 중성화하지 않은 암컷 미니어처 슈나우저 개가 귓바퀴의 소양감, 통증 및 상처치유의 지연을 주증으로 내원하였다. 환자의 혈청 성장호르몬 농도가 참고범위 이하로 측정되었으며 자일라진 자극검사를 통해 뇌하수체 왜소증으로 진단되었다. 보호자가 원하지 않아 성장호르몬 및 프로게스틴 치료는 진행하지 않았으며, 탈모의 개선을 목적으로 멜라토닌 투여를 시작하였다. 멜라토닌 투여 이후, 귓바퀴의 탈모가 개선되는 것을 확인할 수 있었다.

A 13-month old, intact female, miniature Schnauzer dog was presented with history of dermatitis, pruritus and pain of ear pinnae with delayed puberty. The basal serum growth hormone level was 0.01 ng/ml, which was much lower than the reference range (1.80-2.00 ng/ml). On the xylazine stimulation test, the dog was no responsive to administration of xylazine. The dog was diagnosed as isolated type pituitary dwarfism. Treatment was aimed to improve alopecia with oral melatonin. After initiation of treatment, alopecia of the ear pinnae has been improved.

키워드

참고문헌

  1. Andresen E, Willeberg P. Pituitary dwarfism in German shepherd dogs: additional evidence of simple, autosomal recessive inheritance. Nord Vet Med 1976; 28: 481-486.
  2. Ascacio-Martinez JA, Barrera-Saldana HA. A dog growth hormone cDNA codes for a mature protein identical to pig growth hormone. Gene 1994; 143: 277-280. https://doi.org/10.1016/0378-1119(94)90110-4
  3. Bhatti SF, De Vliegher SP, Mol JA, Van Ham LM, Kooistra HS. Ghrelin-stimulation test in the diagnosis of canine pituitary dwarfism. Res Vet Sci 2006; 81: 24-30. https://doi.org/10.1016/j.rvsc.2005.09.009
  4. Diaz SF, Torres SM, Nogueira SA, Gilbert S, Jessen CR. The impact of body site, topical melatonin and brushing on hair regrowth after clipping normal Siberian Husky dogs. Vet Dermatol 2006; 17: 45-50. https://doi.org/10.1111/j.1365-3164.2005.00497.x
  5. Eigenmann JE, Eigenmann RY. Radioimmunoassay of canine growth hormone. Acta Endocrinol 1981; 98: 514-520.
  6. Fischer TW, Slominski A, Tobin DJ, Paus R. Melatonin and the hair follicle. J Pineal Res 2008; 44: 1-15.
  7. Knottenbelt CM, Herrtage ME. Use of proligestone in the management of three German shepherd dogs with pituitary dwarfism. J Small Anim Pract 2002; 43: 164-170. https://doi.org/10.1111/j.1748-5827.2002.tb00051.x
  8. Kooistra HS, Voorhout G, Selman PJ, Rijnberk A. Progestininduced growth hormone (GH) production in the treatment of dogs with congenital GH deficiency. Domest Anim Endocrinol 1998; 15: 93-102. https://doi.org/10.1016/S0739-7240(97)00081-7
  9. Lothrop CD. Pathophysiology of growth-hormone responsive dermatosis. Comp Cont Edu Pract Vet 1988; 10: 1346.
  10. Tomasetto C, Wendling C, Rio MC, Poitras P. Identification of cDNA encoding motilin related peptide/ghrelin precursor from dog fundus. Peptides 2001; 22: 2055-2059. https://doi.org/10.1016/S0196-9781(01)00557-5
  11. van Herpen H, Rijnberk A, Mol JA. Production of antibodies to biosynthetic human growth hormone in the dog. Vet Rec 1994; 134, 171. https://doi.org/10.1136/vr.134.7.171