방사선산업학회지 (Journal of Radiation Industry)

한국방사선산업학회 (Korean Society of Radiation Industry)
권호 표지

방사선 손상 Balb/C 마우스 모델에서 누에 체액(Silkworm Hemolymph)의 간조직 보호 효과

Protective Effect of Silkworm Hemolymph against Gamma Irradiation Induced Damage in the Liver of Mice

  • 남유리 (한국원자력연구원 첨단방사선연구소) ;
  • 강정애 (한국원자력연구원 첨단방사선연구소) ;
  • 노종국 (한국원자력연구원 첨단방사선연구소) ;
  • 최미희 (한국원자력연구원 첨단방사선연구소) ;
  • ;
  • 장범수 (한국원자력연구원 첨단방사선연구소) ;
  • 박상현 (한국원자력연구원 첨단방사선연구소)
  • Nam, You Ree (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute) ;
  • Kang, Jung Ae (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute) ;
  • Rho, Jong Kook (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute) ;
  • Choi, Mi Hee (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute) ;
  • Utami, Hayu Tyas (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute) ;
  • Jang, Beom Su (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute) ;
  • Park, Sang Hyun (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute)
  • 투고 : 2014.04.29
  • 심사 : 2014.05.19
  • 발행 : 2014.05.31

⟨ 이전 논문 다음 논문 ⟩

초록

This study was designed to evaluate the protective effect of silkworm hemolymph against ${\gamma}-irradiation$ induced damage in the liver of mice. Female Balb/C mice (6 weeks old) were exposed to ${\gamma}-irradiation$ (6 Gy) and administered orally to silkworm hemolymph ($5ml\;kg^{-1}$ BW) for 7 days post-irradiation. The body weight, spleen index, plasma aspartate transaminase (AST), plasma alanine transaminase (ALT), and liver malondialdehyde (MDA) levels were determined. Compared with irradiated control mice, the activity of plasma AST and the level of MDA were significantly decreased in mice treated silkworm hemolymph. These results show that silkworm hemolymph is found to have a protective effect against ${\gamma}-irradiation$ induced damage in mice.

키워드

과제정보

연구 과제 주관 기관 : 한국연구재단