The Korean journal of internal medicine

The Korean Association of Internal Medicine (대한내과학회)
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Distant subcutaneous recurrence of a parathyroid carcinoma: abnormal uptakes in the $^{99m}Tc$-sestamibi scan and $^{18}F$-FDG PET/CT imaging

  • Kim, Sang Soo (Department of Internal Medicine, Pusan National University School of Medicine) ;
  • Jeon, Yun Kyung (Department of Internal Medicine, Pusan National University School of Medicine) ;
  • Lee, Soo Hyung (Department of Internal Medicine, Pusan National University School of Medicine) ;
  • Kim, Bo Hyun (Department of Internal Medicine, Pusan National University School of Medicine) ;
  • Kim, Seong Jang (Department of Nuclear Medicine, Pusan National University School of Medicine) ;
  • Kim, Yong Ki (Department of Internal Medicine, Pusan National University School of Medicine) ;
  • Kim, In Ju (Department of Internal Medicine, Pusan National University School of Medicine)
  • Received : 2010.01.13
  • Accepted : 2010.08.19
  • Published : 2014.05.01
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Abstract

We report a rare case of distant subcutaneous parathyroid carcinoma recurrence. A 50year-old woman was referred to our hospital because of sustained hypercalcemia despite surgical removal of a parathyroid carcinoma. A focal uptake in the upper mediastinal area was detected in a $^{99m}Tc$-sestamibi scan, and $^{18}F$-fluorodeoxyglucose (FDG) positron-emission tomography (PET)/computed tomography (CT) imaging demonstrated a subcutaneous mass. She underwent tumor resection, and the pathological findings were consistent with a parathyroid carcinoma. The postoperative serum parathyroid hormone (PTH) level remained within normal limits. However, a new palpable solitary mass was identified in the upper portion of the left breast 1 year postoperatively. Both a $^{99m}Tc$sestamibi scan and $^{18}F$-FDG PET/CT imaging revealed an abnormal lesion in the upper breast, and subsequent pathology reports confirmed parathyroid carcinoma metastasis. Serum PTH and calcium levels fell within normal ranges after tumor resection. Two subcutaneous recurrent lesions appeared likely due to tumor seeding during the previous endoscopic operation at a local hospital.

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References

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  3. The EANM practice guidelines for parathyroid imaging vol.48, pp.9, 2014, https://doi.org/10.1007/s00259-021-05334-y