The Korean journal of internal medicine

The Korean Association of Internal Medicine (대한내과학회)
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Survey of perinatal hepatitis B virus transmission after Korean National Prevention Program in a tertiary hospital

  • Kim, Jae Hoon (Gachon University School of Medicine, Gachon University Gil Medical Center) ;
  • Kim, Ju Seung (Department of Internal Medicine, Gachon University Gil Medical Center) ;
  • Lee, Jong Joon (Department of Internal Medicine, Gachon University Gil Medical Center) ;
  • Kim, Jung Ho (Department of Internal Medicine, Gachon University Gil Medical Center) ;
  • Kim, Suk Young (Department of Obstetrics and Gynecology, Gachon University Gil Medical Center) ;
  • Jung, Young Kul (Department of Internal Medicine, Gachon University Gil Medical Center) ;
  • Kwon, Oh Sang (Department of Internal Medicine, Gachon University Gil Medical Center) ;
  • Kim, Yun Soo (Department of Internal Medicine, Gachon University Gil Medical Center) ;
  • Choi, Duck Joo (Department of Internal Medicine, Gachon University Gil Medical Center) ;
  • Kim, Ju Hyun (Department of Internal Medicine, Gachon University Gil Medical Center)
  • Received : 2013.06.25
  • Accepted : 2013.08.13
  • Published : 2014.05.01
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Abstract

Background/Aims: The Ministry of Health and Welfare and the Korea Centers for Disease Control and Prevention in South Korea have been organizing hepatitis B virus (HBV) vertical infection prevention projects since July 2002. In this single-institute study, the results of surveys conducted in target mothers who delivered babies in a tertiary hospital were investigated and analyzed. Methods: Of the 9,281 mothers and their 9,824 neonates born between July 2002 and December 2012, 308 hepatitis B surface antigen (HBsAg)-positive mothers and their 319 neonates were selected for this study, and their records were analyzed retrospectively. Results: A total of 308 mothers were HBsAg-positive, with an HBV prevalence of 3.32% (308/9,281). There were 319 neonates born to these HBsAg-positive mothers, and 252 were confirmed to as either HBsAg-positive or -negative. Four were confirmed as HBsAg-positive, with a 1.59% (4/252) HBV vertical infection rate. All the mothers of neonates who had an HBV vertical infection were hepatitis B e antigen (HBeAg)-positive. Among the HBsAg-positive neonates, three were HBeAg-positive and had an HBV DNA titer of $1.0{\times}10^8$ copies/mL. Conclusions: The HBV prevalence of mothers was 3.32% (308/9,281), and their vertical infection rate was 1.59% (4/252). Thus, the South Korean HBV vertical infection prevention projects are effective, and, accordingly, HBV prevalence in South Korea is expected to decrease continuously.

Keywords

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