Molecules and Cells

Korean Society for Molecular and Cellular Biology (한국분자세포생물학회)
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Neuronal Activity-Dependent Regulation of MicroRNAs

  • Sim, Su-Eon (Department of Brain and Cognitive Sciences, College of Natural Sciences, Seoul National University) ;
  • Bakes, Joseph (Department of Brain and Cognitive Sciences, College of Natural Sciences, Seoul National University) ;
  • Kaang, Bong-Kiun (Department of Brain and Cognitive Sciences, College of Natural Sciences, Seoul National University)
  • Received : 2014.05.19
  • Accepted : 2014.05.26
  • Published : 2014.07.31
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Abstract

MicroRNAs are non-coding short (~23 nucleotides) RNAs that mediate post-transcriptional regulation through sequence-specific gene silencing. The role of miRNAs in neuronal development, synapse formation and synaptic plasticity has been highlighted. However, the role of neuronal activity on miRNA regulation has been less focused. Neuronal activity-dependent regulation of miRNA may finetune gene expression in response to synaptic plasticity and memory formation. Here, we provide an overview of miRNA regulation by neuronal activity including high-throughput screening studies. We also discuss the possible molecular mechanisms of activity-dependent induction and turnover of miRNAs.

Keywords

References

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